Schizophrenia: The new etiological synthesis

Post by singingfish » Sat, Dec 17, 2022, 8:44 PM UTC

psychphysic wrote: post #95

singingfish wrote: post #62

Earlier quoted context omitted.

Schizophrenia is a degenerative condition where positive symptoms start to be replaced by negative symptoms over the course of years. I've worked in acute adult mental health, and did a few shifts in the long term wards and the difference between people earlier on in the course of their illness versus the end stages are stark.

I'm not fully convinced here, I bet those long term patients were on antipsychotics nearly all of which have extrapyramidal side effects, pretty identical to negative symptoms.

Post by hackerman123469 » Mon, Dec 19, 2022, 10:12 AM UTC

bitL wrote: post #76

conviencefee999 wrote: post #22

Earlier quoted context omitted.

It's a neurological disorder and is more complicated than a one off bit, especially when it involved the entire CNS because it's associated with the brain. Many of these issues can't be cured as easy as flipping a bit.

I mean if it is an unrecoverable loss of glial cells during puberty (AFAIK most diagnoses start during that time) then nobody would be able to "flip the bit" back anyway. As glial cells feed and protect neurons, their lack will likely have unrepairable consequences, unless the remaining ones are somewhat boosted to partially cover the functionality of the missing ones. I am interested in this topic because a cousin h…

Post by niemal_dev » Mon, Dec 19, 2022, 4:01 PM UTC

comfypotato wrote: post #98

psychphysic wrote: post #95

Earlier quoted context omitted.

I'm not fully convinced here, I bet those long term patients were on antipsychotics nearly all of which have extrapyramidal side effects, pretty identical to negative symptoms.

It’s worth mentioning here that antipsychotics have come a long way since lithium. (Posting from the US with our unfortunate (relative to the developed world) healthcare system.) There’s a handful of antipsychotics and mood stabilizers that have been developed in the last couple of decades that have had unprecedented success with Schizophrenia and Bipolar Disorder. They typically cost $20,000.00 per year before insur…

Post by Obscurity4340 » Tue, Dec 27, 2022, 3:20 PM UTC

psychphysic wrote: post #101

comfypotato wrote: post #98

Earlier quoted context omitted.

It’s worth mentioning here that antipsychotics have come a long way since lithium. (Posting from the US with our unfortunate (relative to the developed world) healthcare system.) There’s a handful of antipsychotics and mood stabilizers that have been developed in the last couple of decades that have had unprecedented success with Schizophrenia and Bipolar Disorder. They typically cost $20,000.00 per year before insur…

> Please forgive the Lisp-ish parentheses. I figure it’s halfway acceptable on HN. Haha it did make me wander if there was an Emacs HN client with paren mode. > It’s worth mentioning here that antipsychotics have come a long way since lithium. It's not really related to your comment which is interesting and useful to hear in of its self. But Lithium is not a antipsychotic it's a mood stabiliser and remains to this da…