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Well, the whole reason why this situation took place is because people in red states are fed up with the influx of blue voters, that end up bringing in the exact problems that made them relocate. This is how empires fall. As people with different political views no longer depend on each other economically, they drift more and more into opposite directions, until they do not want to share the same government anymore.
The issue is that the senate can be filibustered with 5% of the US population's backing. A majority vote requires 8%. A fillibuster-proof majority requires 12%.
This implies that it would not take many geographically mobile liberals to end the Republican party forever.
Ironically, the Republican party invented this technique back when they were what we would currently call a liberal party. It worked great. Read up on carpetbaggers.