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In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

nature.com

121–130 of 170 posts

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#121

I'll be happy if two things happen: 1. I can have "better years" in the same lifespan. Lots of energy at 90 for instance. 2. I can increase the lifespan of my dog by 50 years :)

If you have a large dog, you can sign up for a lifespan extension study now with rapamycin. https://dogagingproject.org/

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#122

Earlier quoted context omitted.

I'm just not interesting in brainwashing myself to be suicidal

Spiritually suicidal maybe, but not physical suicide

https://en.wikipedia.org/wiki/Sokushinbutsu - never underestimate how stupid some people are

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#123
post #3

You can do this at home, except for the little inconvenience that growth hormone is a scheduled drug. I wonder what the results would be with just growth hormone. Let's ask Sylvester Stallone[1] who looks great for 75 and got caught trying to get into Australia with illicit Growth Hormone a while ago[2]. [1] https://en.wikipedia.org/wiki/Sylvester_Stallone [2] https://abcnews.go.com/Health/ActiveAging/story?id=317601…

It has to be refrigerated, which makes travel difficult. Not to mention the hypodermics needed for intramuscular injections.

Growth hormone can be injected subcutaneously. They now come in convenient pens with adjustable dosage that are so fine you can't feel the prick. But yes, they must remain refrigerated.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#124
post #3

You can do this at home, except for the little inconvenience that growth hormone is a scheduled drug. I wonder what the results would be with just growth hormone. Let's ask Sylvester Stallone[1] who looks great for 75 and got caught trying to get into Australia with illicit Growth Hormone a while ago[2]. [1] https://en.wikipedia.org/wiki/Sylvester_Stallone [2] https://abcnews.go.com/Health/ActiveAging/story?id=317601…

GH by itself decreases insulin sensitivity, aggravates insulin resistance, and may significantly increase cancer risk.

Insulin sensitivity and resistance are a non-issue if combining HGH with a low carb diet (such as keto) and fasting.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#125
Before you run out to get some growth hormone, you should be aware that metformin seems to extend health span and life span quite effectively alone.

Even people with diabetes live longer on metformin than a control group that is not on metformin. https://pubmed.ncbi.nlm.nih.gov/25041462/

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#126

Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.

Altered Carbon, and to a lesser extend Upload! touch on this dystopian part - the great leveller is that every billionaire will one day die - imagine if that wasn't the case, and they could keep hoarding wealth and having undue political influence.

What a pleasure to see Altered Carbon mentioned here. Amazing show.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#127

Earlier quoted context omitted.

Spiritually suicidal maybe, but not physical suicide

https://en.wikipedia.org/wiki/Sokushinbutsu - never underestimate how stupid some people are

Why is that stupid? Someone who is enlightened can no longer create karma, so it isn't really suicide

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#128

Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.

I don't understand people who don't want to at least have the option. I mean, if it turns out you don't like living longer you could just opt out?

As far as I can tell, "I don't want to live forever anyway" is just cope.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#129

Earlier quoted context omitted.

Sounds like a self solving problem. I reckon people will start caring about their despots if they expect to live a millennium under the despots' boot

I suspect people not caring is not the main underlying cause of despots.

Despots make sure the people who care are killed off (or at least marginalized, say in prison), leaving only people who don't.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#130
post #73

Earlier quoted context omitted.

Super intelligent, immortal, and free of cancer, diabetes, Alzheimer, and MS.

And with a single giant ear on their back. Don’t forget the giant ear. (Weirdly, just saw a breathless article talking about how 3D bioprinting obviates the use of rib cartilage that the human-ear-on-a-mouse 25 years ago was also supposed to end).

Shh....! They can hear you!
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