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Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms

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Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms

#121

Post by fjabre »

cmehdy wrote: post #118
fjabre wrote: post #114

Earlier quoted context omitted.

It is precisely because I care that I commented so that another one may find it. Just for the sake of clarity I am referring to a level 5 trip. Two trips in row with different outcomes? This is not a question that would be posed by someone who has experienced a level 5 trip. Why? It becomes self evident. But it is not something I can 'prove' to you. You have to see for yourself. Regarding outcomes - One has either br…

I can only assume you refer to "level 5" from a personal source rather than DMT-Nexus (which only has 3 levels) or PsychonautWiki (which mentions levels rather freely and goes to Levels 8+, also spreading out the descriptions into various categories). It's going to be impossible to convince you that your subjective experience isn't an absolute truth because it seems like the entire foundation of your approach to the…

I am not looking to debate or argue. I am simply stating my beliefs. You are free to disagree or take nothing at all from it. To become critical of me or my understanding shows how little you have learned from your experiences.

Depression comes from the same place as your judgement of others.

All experience is subjective. That is my point.

You however limit your experience to the world view of your senses and what science and your cultural background have told you are true. It is as simple as that.

That is valid. But it wont cure Depression. The analytical mind has no clue. That is why. That is my belief. Take what you want or take nothing at all.

Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms

#122

Post by forgotmypw17 »

spyder wrote: post #113
forgotmypw17 wrote: post #73

Earlier quoted context omitted.

Why does it have to be commercialized? Personally, I think the best option is it gets mainstreamed by knowledgeble guides working with individuals through the process, the mushroom growing is done by small-scale growers who do it with the passion and love this Medicine deserves, and the pill-makers are kept far and away from it.

Why does it have to be commercialized? In general it doesn't has to be, but in this case the research is done by a for-profit company which expects to see a return on their investments.

Ah, good point.

Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms

#123

Post by cmehdy »

fjabre wrote: post #121
cmehdy wrote: post #118

Earlier quoted context omitted.

I can only assume you refer to "level 5" from a personal source rather than DMT-Nexus (which only has 3 levels) or PsychonautWiki (which mentions levels rather freely and goes to Levels 8+, also spreading out the descriptions into various categories). It's going to be impossible to convince you that your subjective experience isn't an absolute truth because it seems like the entire foundation of your approach to the…

I am not looking to debate or argue. I am simply stating my beliefs. You are free to disagree or take nothing at all from it. To become critical of me or my understanding shows how little you have learned from your experiences. Depression comes from the same place as your judgement of others. All experience is subjective. That is my point. You however limit your experience to the world view of your senses and what sc…

> To become critical of me or my understanding shows how little you have learned from your experiences.

That's just an attempt to shield yourself from any kind of external perspective.

> Depression comes from the same place as your judgement of others.

Glad you, on your own, have managed to solve remotely a problem that is a complex combination of multiple traumas, PTSD, neurochemical issues and psychological ones. Or more likely, you've lost all sympathy from me in this response as you've revealed just low little your personal experiences have fundamentally changed in your ability to extend and practice empathy, and therefore the very limited extent to which your experiences retain value in the bigger scheme of things in this discussion.

Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms

#124

Post by goodroot »

nobodyofnote wrote: post #109
goodroot wrote: post #79

Earlier quoted context omitted.

> 25mg psilocybin isn't something you can just pop at the beginning of a workday. I would disagree. For many, 25mg is sub-perceptual. Source: have done this over several year.

I think you're confusing 25mg of psilocybin with a microdose of 25mg of dried mushrooms. 25mg of pure psilocybin is anything but sub-perceptual.

Ahhh - yes, missed this.

Holy hell, yeah that'd blow the roof off for sure.

Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms

#125

Post by me_me_me »

WalterSear wrote: post #86
goodroot wrote: post #79

Earlier quoted context omitted.

> 25mg psilocybin isn't something you can just pop at the beginning of a workday. I would disagree. For many, 25mg is sub-perceptual. Source: have done this over several year.

3-5 grams of mushrooms? I want to work where you work. I hope it doesn't involve heavy machinery.

it depend on your weight, and potency of batch.

I have settled on 2g every 3rd day. 1g dose seems to work only on empty stomach and I have to pay attention to feel difference in my mood.

I can easily see a big guy taking 3-5g and not feeling much beyond mood boost.

Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms

#126

Post by me_me_me »

goodroot wrote: post #81

Have a lot of experience with microdosing psilocybin, as well as with psychedelics like Ayahuasca. My experience with both as a means to remedy depression have been significant. It is analagous to having a lamp in a dark forest. It won't get you through it itself, you need courage, and other tools like meditation (your machete), exercise (your provisions) and intention (your compass) to succeed. But with it, everythi…

microdosing psilocybin is definitely not the silver bullet.

But it helps me realise what is it like to feel normal. Depression is insidious beast. It blinds you and you forget what its like to feel normal.

I really like your analogy of having multiple tools in order to fight depression.

Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms

#127

Post by kingkawn »

wufufufu wrote: post #56
kingkawn wrote: post #49

Earlier quoted context omitted.

That number is misleading without context for how effective other drugs are and in comparison to placebo. Given that placebo was ~8% effective this is a highly promising treatment.

I think that was the control group, not placebo. But I didn't read the study in depth.

Control groups are given placebos…
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