And we also know people who have Alzheimer nap more. Which they are not sure quite yet on correlation or causation related to this study.
Biomarker of Alzheimer's found to be regulated by sleep cycles
121–130 of 181 posts
Re: Biomarker of Alzheimer's found to be regulated by sleep cycles
#122Earlier quoted context omitted.
I spent a summer in Thailand on a small island living in a remote shack with no power. I was totally beholden to the natural light other than an oil lamp and I tiny pen torch I had. I had the best sleep I've ever had, but I'd wake super early with the sun rise and actually feel like getting up and doing stuff.
I have zero doubts about everything you said. Anecdotally, the last time electricity went down in the whole neighborhood we were forced to use candles and it was .. magical. Stupidly magical.. the light warmth, the decay, the flicker.. my mind went into creative mode right away. It's the opposite of distraction we can get 24/7 these days.
in the early morning, having it still be dark was a wonderful feeling, and then when power was restored and all the lights came back on outside, i was quite shocked how my good feelings went away...
after that, i started to wonder what the whole effect of endless light polution is having on societey...
Re: Biomarker of Alzheimer's found to be regulated by sleep cycles
#123What does this mean for people with severe Delayed Phase Sleep Syndrome (DSPS)? I do not feel the need for sleep until usually about 2am, and I find it exceedingly difficult to wake up before 10am. And yes, it's made it extremely difficult to live a "normal" life like your typical person who can wake up at 7am without issue. It's been a problem with relationships, poor performance in school, issues in promotions and…
I wasn't diagnosed with this but I had the symptoms and the consequences you mentioned. It took a long time to fix. Here's some things I tried. Some may have helped or none may have helped. * I bought blackout blinds and use a sleeping mask (sometimes earplugs) * I bought a bright light ( https://www.amazon.co.uk/gp/product/B07FFJYMVS ) and a smart plug. 15 mins before I wanted to wake up I would have a timer turn on…
Re: Biomarker of Alzheimer's found to be regulated by sleep cycles
#124You should take these findings with a big grain of salt. Remember we don't yet even have a causal model of Alzheimer's and dementia. Amyloid plaques are strongly associated with Alzheimer's but it's not clear if they're the actual cause or if they're just a residual indicator that something else has already gone wrong in the brain. As a counterpoint to the amyloid hypothesis, we also see amyloid build ups in patients…
Re: Biomarker of Alzheimer's found to be regulated by sleep cycles
#125What does this mean for people with severe Delayed Phase Sleep Syndrome (DSPS)? I do not feel the need for sleep until usually about 2am, and I find it exceedingly difficult to wake up before 10am. And yes, it's made it extremely difficult to live a "normal" life like your typical person who can wake up at 7am without issue. It's been a problem with relationships, poor performance in school, issues in promotions and…
I wasn't diagnosed with this but I had the symptoms and the consequences you mentioned. It took a long time to fix. Here's some things I tried. Some may have helped or none may have helped. * I bought blackout blinds and use a sleeping mask (sometimes earplugs) * I bought a bright light ( https://www.amazon.co.uk/gp/product/B07FFJYMVS ) and a smart plug. 15 mins before I wanted to wake up I would have a timer turn on…
Re: Biomarker of Alzheimer's found to be regulated by sleep cycles
#126Earlier quoted context omitted.
I'm not a doctor, just a person who also has Alzheimer's in his family, so I've thought and read a lot about it. My recipe is basically: Sleep enough, exercise (especially outside), eat right, make sure your brain is active and engaged on a regular basis (read real books, challenge yourself by getting out of your intellectual comfort zone). Studies show that coffee is good for Alzheimer's, so as long as you're not us…
Is it coffee? Or is it caffeine (i.e. tea, etc.)? I consume around 500-1000mg of caffeine a day (very carefully timed so as not to get jitters). I can't handle a higher dose of Adderall XR, so I've embraced my higher caffeine intakes as a way to soothe the mind. That said, I don't care for the flavor of coffee, so I typically consume it via Red Bull/5hr/tablet form.
Re: Biomarker of Alzheimer's found to be regulated by sleep cycles
#127What does this mean for people with severe Delayed Phase Sleep Syndrome (DSPS)? I do not feel the need for sleep until usually about 2am, and I find it exceedingly difficult to wake up before 10am. And yes, it's made it extremely difficult to live a "normal" life like your typical person who can wake up at 7am without issue. It's been a problem with relationships, poor performance in school, issues in promotions and…
There's no literature I'm aware of studying links between DSPD and Alzheimer's. However, DSPD is characterized as delayed sleep...not less sleep. As long as you're getting sufficient sleep and feel rested when you do sleep, I don't think it matters when you do it as it relates to this issue. As someone who's dealt with DSPD in his 20s, I'll refrain from advice. I got no end of people telling me to exercise more, drin…
I usually sleep 9-10 hours and feel very tired all day. If I sleep 11-11.5 hours, then I'll feel rested, but this rarely happens.
Don't get me wrong, there are plenty of days I have an early meeting morning and sleep for 6-7h, but I will feel even more tired than when I sleep "only" 9h. Frustrating because 9h is on the verge of "too much sleep" for most people.
Re: Biomarker of Alzheimer's found to be regulated by sleep cycles
#128What does this mean for people with severe Delayed Phase Sleep Syndrome (DSPS)? I do not feel the need for sleep until usually about 2am, and I find it exceedingly difficult to wake up before 10am. And yes, it's made it extremely difficult to live a "normal" life like your typical person who can wake up at 7am without issue. It's been a problem with relationships, poor performance in school, issues in promotions and…
Have you tried biphasic sleep? A cycle with one 2-7am sleep and a significant afternoon sleep (don't call it a nap-- at least 90 minutes) would get you enough sleep. It's easier to carve out that 90 minutes than it is to change all the things you need to change to shift your natural cycle.
Re: Biomarker of Alzheimer's found to be regulated by sleep cycles
#129Earlier quoted context omitted.
Indeed, and after setting up the auto wake up / sleep cycle, I had to turn it off because it was leading me to want to fall asleep at night when I still had a ton of work to get through As great as it would be to keep a more natural "lighting" cycle around the house, the truth is my modern obligations won't allow for that, so I have the lights on at full blast until midnight quite frequently I look forward to my reti…
I think it's worth asking how much more time spent equals more productivity. For me, that's only true for very short periods. I find I'm way more productive for the long haul if I'm getting plenty of sleep. The thing that convinced me to try was this presentation from game developers on the limits of crunch time: https://lostgarden.home.blog/2008/09/28/rules-of-productivit...
Re: Biomarker of Alzheimer's found to be regulated by sleep cycles
#130I'm curious if sleep aids, whether it's OTC like melatonin or Rx like trazodone and Ambien, can help this situation. Is it just the sleep that's beneficial or is it "natural" sleep (that term doesn't mean anything, but you get the point of it)? In other words, should people who have difficulty sleeping look to aids as a way of staving off dementia later in life.
All cause mortality is absurdly higher if you use drugs to sleep, including OTC stuff[0]. So, probably not. Almost certainly same story with other "meds" that dipshits pop like popcorn[1]. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883191/ [1] https://www.nhs.uk/news/medication/widely-used-class-drugs-l...