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Biomarker of Alzheimer's found to be regulated by sleep cycles

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Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#121
This article is relevant to people who nap. (And I think napping, over nighttime sleep fragmentation or other sleep stuff, going off the supplementary materials of the original study)

And we also know people who have Alzheimer nap more. Which they are not sure quite yet on correlation or causation related to this study.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#122
post #86

Earlier quoted context omitted.

I spent a summer in Thailand on a small island living in a remote shack with no power. I was totally beholden to the natural light other than an oil lamp and I tiny pen torch I had. I had the best sleep I've ever had, but I'd wake super early with the sun rise and actually feel like getting up and doing stuff.

I have zero doubts about everything you said. Anecdotally, the last time electricity went down in the whole neighborhood we were forced to use candles and it was .. magical. Stupidly magical.. the light warmth, the decay, the flicker.. my mind went into creative mode right away. It's the opposite of distraction we can get 24/7 these days.

yes, same thing here

in the early morning, having it still be dark was a wonderful feeling, and then when power was restored and all the lights came back on outside, i was quite shocked how my good feelings went away...

after that, i started to wonder what the whole effect of endless light polution is having on societey...

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#123
post #105

What does this mean for people with severe Delayed Phase Sleep Syndrome (DSPS)? I do not feel the need for sleep until usually about 2am, and I find it exceedingly difficult to wake up before 10am. And yes, it's made it extremely difficult to live a "normal" life like your typical person who can wake up at 7am without issue. It's been a problem with relationships, poor performance in school, issues in promotions and…

I wasn't diagnosed with this but I had the symptoms and the consequences you mentioned. It took a long time to fix. Here's some things I tried. Some may have helped or none may have helped. * I bought blackout blinds and use a sleeping mask (sometimes earplugs) * I bought a bright light ( https://www.amazon.co.uk/gp/product/B07FFJYMVS ) and a smart plug. 15 mins before I wanted to wake up I would have a timer turn on…

Can confirm that similar steps plus mindfulness meditation plus becoming father has dramatically changed my sleep patterns. - And I have had sleep disorder for decades. It took two years (and becoming father) and another two years until I adopted the new sleep pattern.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#124

You should take these findings with a big grain of salt. Remember we don't yet even have a causal model of Alzheimer's and dementia. Amyloid plaques are strongly associated with Alzheimer's but it's not clear if they're the actual cause or if they're just a residual indicator that something else has already gone wrong in the brain. As a counterpoint to the amyloid hypothesis, we also see amyloid build ups in patients…

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Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#125
post #105

What does this mean for people with severe Delayed Phase Sleep Syndrome (DSPS)? I do not feel the need for sleep until usually about 2am, and I find it exceedingly difficult to wake up before 10am. And yes, it's made it extremely difficult to live a "normal" life like your typical person who can wake up at 7am without issue. It's been a problem with relationships, poor performance in school, issues in promotions and…

I wasn't diagnosed with this but I had the symptoms and the consequences you mentioned. It took a long time to fix. Here's some things I tried. Some may have helped or none may have helped. * I bought blackout blinds and use a sleeping mask (sometimes earplugs) * I bought a bright light ( https://www.amazon.co.uk/gp/product/B07FFJYMVS ) and a smart plug. 15 mins before I wanted to wake up I would have a timer turn on…

This year I found the most effective method, I have tried everything but wasn't enough: sunshine, flux, sleep hygiene, diet, exercise. Basically the method is as soon as you wake up you start working out, the longer and harder you work out the earlier you will get up the next day.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#126
post #18

Earlier quoted context omitted.

I'm not a doctor, just a person who also has Alzheimer's in his family, so I've thought and read a lot about it. My recipe is basically: Sleep enough, exercise (especially outside), eat right, make sure your brain is active and engaged on a regular basis (read real books, challenge yourself by getting out of your intellectual comfort zone). Studies show that coffee is good for Alzheimer's, so as long as you're not us…

Is it coffee? Or is it caffeine (i.e. tea, etc.)? I consume around 500-1000mg of caffeine a day (very carefully timed so as not to get jitters). I can't handle a higher dose of Adderall XR, so I've embraced my higher caffeine intakes as a way to soothe the mind. That said, I don't care for the flavor of coffee, so I typically consume it via Red Bull/5hr/tablet form.

This is a separate in-vitro study that seems to suggest it's not the caffeine that is helping https://www.frontiersin.org/articles/10.3389/fnins.2018.0073...

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#127
post #117

What does this mean for people with severe Delayed Phase Sleep Syndrome (DSPS)? I do not feel the need for sleep until usually about 2am, and I find it exceedingly difficult to wake up before 10am. And yes, it's made it extremely difficult to live a "normal" life like your typical person who can wake up at 7am without issue. It's been a problem with relationships, poor performance in school, issues in promotions and…

There's no literature I'm aware of studying links between DSPD and Alzheimer's. However, DSPD is characterized as delayed sleep...not less sleep. As long as you're getting sufficient sleep and feel rested when you do sleep, I don't think it matters when you do it as it relates to this issue. As someone who's dealt with DSPD in his 20s, I'll refrain from advice. I got no end of people telling me to exercise more, drin…

>As long as you're getting sufficient sleep and feel rested when you do sleep, I don't think it matters when you do it as it relates to this issue.

I usually sleep 9-10 hours and feel very tired all day. If I sleep 11-11.5 hours, then I'll feel rested, but this rarely happens.

Don't get me wrong, there are plenty of days I have an early meeting morning and sleep for 6-7h, but I will feel even more tired than when I sleep "only" 9h. Frustrating because 9h is on the verge of "too much sleep" for most people.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#128
post #106

What does this mean for people with severe Delayed Phase Sleep Syndrome (DSPS)? I do not feel the need for sleep until usually about 2am, and I find it exceedingly difficult to wake up before 10am. And yes, it's made it extremely difficult to live a "normal" life like your typical person who can wake up at 7am without issue. It's been a problem with relationships, poor performance in school, issues in promotions and…

Have you tried biphasic sleep? A cycle with one 2-7am sleep and a significant afternoon sleep (don't call it a nap-- at least 90 minutes) would get you enough sleep. It's easier to carve out that 90 minutes than it is to change all the things you need to change to shift your natural cycle.

Maybe I should give this a try. I've never been a nap person unless I got <5-6h of sleep the previous day, but seems worth a try.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#129

Earlier quoted context omitted.

Indeed, and after setting up the auto wake up / sleep cycle, I had to turn it off because it was leading me to want to fall asleep at night when I still had a ton of work to get through As great as it would be to keep a more natural "lighting" cycle around the house, the truth is my modern obligations won't allow for that, so I have the lights on at full blast until midnight quite frequently I look forward to my reti…

I think it's worth asking how much more time spent equals more productivity. For me, that's only true for very short periods. I find I'm way more productive for the long haul if I'm getting plenty of sleep. The thing that convinced me to try was this presentation from game developers on the limits of crunch time: https://lostgarden.home.blog/2008/09/28/rules-of-productivit...

I agree wholeheartedly. Unfortunately, deadlines often have a way of making it impossible to have a full night of sleep.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#130

I'm curious if sleep aids, whether it's OTC like melatonin or Rx like trazodone and Ambien, can help this situation. Is it just the sleep that's beneficial or is it "natural" sleep (that term doesn't mean anything, but you get the point of it)? In other words, should people who have difficulty sleeping look to aids as a way of staving off dementia later in life.

All cause mortality is absurdly higher if you use drugs to sleep, including OTC stuff[0]. So, probably not. Almost certainly same story with other "meds" that dipshits pop like popcorn[1]. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883191/ [1] https://www.nhs.uk/news/medication/widely-used-class-drugs-l...

All cause mortality of getting 5 or less hours of sleep a night is also about 2X though, and along with the mortality risk comes a massive decrease in quality of life. Obviously non-medical methods should be tried first (When I was having major issues with sleep I was able to get it under control with the help of a specialized therapist), but for someone who is having serious issues sleeping the pills can be the lesser evil.
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