Intermittent fasting increases hippocampal neurogenesis in mice • Hacker News Board

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#121

Post by SubiculumCode » Mon, Nov 02, 2020, 2:56 AM UTC

ckemere wrote: post #105

SubiculumCode wrote: post #90

Earlier quoted context omitted.

I don't think that we need to apply a value to neurogenesis and I do not think the authors do either except that it seems to be correlated with other quote good behaviors like exercise. Presumably neurogenesis is occurring all the time and is restricted to a small set of regions in the brain and the new neurons form in just those very strict set of regions. Those neurons are not moving to the neocortex, just a few mi…

I think the primary "function" attributed to adult hippocampal neurogenesis is improved memory. But the parent comment is unfair insofar as scientists don't randomly chose to food deprive or "vivisect" animals because they think it's intrinsically fun. Running these experiments requires a huge amount of annoying busy work that I can't imagine anyone choosing to do without being paid or having some other motive. In pa…

The degree to which neurogenesis improves memory is far from settled, or accepted.

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#122

Post by ip26 » Mon, Nov 02, 2020, 2:58 AM UTC

TuringNYC wrote: post #120

ip26 wrote: post #117

Earlier quoted context omitted.

There's a point it becomes destructive. I tend to ignore hunger, and I find after 20 hours or so my mood nosedives, I get shaky, generally things go south quickly and even if I eat I'm still a wreck for a while. 12-16hrs is probably the sweet spot from my experience. BMI 18-19 for reference.

Your IF experience sounds hard, is IF worth it for you? Would you mind sharing your BMI from before IF? Also curious if you feel IF is better than the alternatives (e.g., Keto, which for me has been the "easiest" of the effective diets)

Oh IF is just how I have generally lived my life, long before it was "a thing". So not much to compare.

I did have a really good experience doing long fasted running in the morning. At first I couldn't go three miles without breakfast. But eventually I could do twelve straight out of bed and feel great.

As I understand, fasting trains your body to supply blood glucose from fat stores, which breaks your brain's craving for sugary foods- which are a crutch for getting your blood sugar up. (Remember, your brain runs mainly on blood glucose)

Keto does the same thing a different way. But to me IF is way easier and healthier. (I strive to eat a Mediterranean style diet which ain't Keto!)

I would say the experience for me is really good- as long as I avoid the cliff, which is what I was warning about. Basically, just don't try to get all extreme thinking longer fasts are always better.

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#123

Post by loco5niner » Mon, Nov 02, 2020, 4:55 PM UTC

jmcgough wrote: post #104

kitotik wrote: post #28

Earlier quoted context omitted.

:/ Anyone care to ELI5 please?

I worked in a neurogenesis lab for three years, so my attempt: The cells in our body are continuously replaced throughout our life, with the exception of our brain cells. For many many years we believed that mammals didn't create new brains cells in adulthood. You were born, your brain grew and developed as you became an adult, and then you were done. About 20 years ago we realized that that was mostly true, but smal…

>The cells in our body are continuously replaced throughout our life, with the exception of our brain cells.

What about teeth?