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An LSD Trip “Off-Switch” May Be Coming Soon

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Re: An LSD Trip “Off-Switch” May Be Coming Soon

#121

Post by heavyset_go »

Any competitive 5-HT2A antagonist will block psychedelic effects from classical psychedelic drugs, and D2 antagonists will block the potential for stimulant-esque psychosis that drugs like LSD can trigger through dopamine agonism.

There are probably hundreds of drugs that fall into these classes, and many of them have significant clinical data to derive their safety profiles from.

If someone comes into a hospital with a bad reaction to psychedelic drugs, it's not uncommon for them to be given something like risperidone, both a 5-HT2A and D2 antagonist, and an anxiolytic to calm them down.

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#122

Post by smabie »

INTPenis wrote: post #10
renewiltord wrote: post #5

Xanax?

I came here to see this. We didn't have Xanax in Sweden growing up but we did carry Valium or Xanor. Xanor has the same active ingredient as Xanax. Someone claimed Valium would help too but I doubt it. I only ever heard of this being used once to stop a bad trip, and I wasn't present.

All benzos are pretty much the same, why would xanax work but not valium?

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#123

Post by heavyset_go »

DyslexicAtheist wrote: post #86
entropyneur wrote: post #12

So no info on what it actually is. Just some company filing a patent. And the fact that they call it "a neutralizer technology" suggests that it's probably just a bunch of BS combined with previously known drugs to make it patentable. I'm pretty sure there's at least some published research on using at least one antipsychotic for that and mountains of "folk research" on using benzodiazepines.

I'm curious what would be the market for this? wouldn't that be an extremely niche scenario within the emergency-response medicine where people inexperienced with LSD who suffer a bad trip ask to be taken off it? afaik LSD isn't a drug that one is likely to OD from either.

There's a weird cottage industry around legalized psychedelics and their use in medicine, so I wouldn't be surprised if some less knowledgeable investors' money is funding this, given that there are hundreds of such drugs already on the market.

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#124

Post by heavyset_go »

ghostbrainalpha wrote: post #104
DyslexicAtheist wrote: post #86

Earlier quoted context omitted.

I'm curious what would be the market for this? wouldn't that be an extremely niche scenario within the emergency-response medicine where people inexperienced with LSD who suffer a bad trip ask to be taken off it? afaik LSD isn't a drug that one is likely to OD from either.

It might make a little sense for Emergency Rooms to have in response to the "bad trips" that result in people calling an ambulance. But I think the primary reason they would want to develop this would be to encourage LSD to be used as a therapy drug. A lot of people would be more comfortable experimenting in a controlled/legal setting if they new they had an off switch in case anything went wrong.

> It might make a little sense for Emergency Rooms to have in response to the "bad trips" that result in people calling an ambulance.

Doctors already have a ton drugs with proven efficacy for treating acute reactions to psychedelics. Many of them are cheap, off patent and have minimal side effects if they aren't taken chronically.

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#125

Post by sibeliuss »

forgotmypw17 wrote: post #26
wreet wrote: post #2

We already have one. Give someone having a bad trip a Xanax and they're good.

Or a bit of MDMA

All of the other responses are accurate -- combining the two will augment and possibly lengthen the experience -- but if you're familiar with both substances enough to feel confident in combining them, I've always found that 70mg dose of MDMA and a big glass of water will pull me right out of a trip that's heading south, and pretty quickly, into more glorious places.

But again, disclaimer: this is really only for folks experienced enough to know how to navigate each separate space well, and for those that have confirmed, tested, pure, high quality MDMA.

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#127

Post by elevenoh »

sjnair96 wrote: post #33
wreet wrote: post #2

We already have one. Give someone having a bad trip a Xanax and they're good.

Antipsychotics seem theoretically (and by online accounts empirically) more effective. While benzos reduce the panic, antipsychotics would function more similarly to an off-switch.

Yep

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#129

Post by godelski »

CameronNemo wrote: post #103
tsjackson wrote: post #92

Earlier quoted context omitted.

Psilocybin (from mushrooms) and MDMA are both fast tracked for FDA approval as adjuncts to therapy. Psychedelics are poised to become the most common psychiatric treatment in the world, with ongoing trials showing huge effects for treating PTSD, addiction, and treatment-resistant depression. Despite a lot of therapeutic promise, LSD has not received as much research attention, primarily because of its duration of eff…

Results from studies that used an antipsychotic across the board would not be generalizeable to traditional experiences. At that point, why use L in the first place if older, faster acting substances are available. Mescaline and psilocybine have been used in spiritual and therapeutic settings for hundreds, if not thousands, of years. Where is the interest in L coming from, if not ease of slipping it past customs and…

I think if one class of drugs has the effect you want (in this case "psychedelics") you'd want to study other drugs in that classification as well.

Since people are studying psilocybine for depression, PTSD, etc, why not others like Mescaline, LSD, or DMT? Why leave something off the table? Maybe LSD is great for a specific type of PTSD and psilocybine for depression? You got to study it to figure out. And who knows, maybe these drugs don't actually help at all. Either way, you have to study them to figure anything out.

> Mescaline and psilocybine have been used in spiritual and therapeutic settings for hundreds, if not thousands, of years.

Yes and no. Those are the active ingredients, but these have not been distilled. From my extremely naive understanding, other chemicals here could affect people differently. So to create a safer and more therapeutic drug. Maybe you even need some of those other chemicals. But you can't find out without testing.

One thing is for sure, in a clinical setting you want very controlled dosages. You're not going to get that by ingesting plants/fungi.

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#130

Post by sibeliuss »

yboris wrote: post #90
thoughtpalette wrote: post #72

Earlier quoted context omitted.

Highly recommend not candy flipping from anecdotal experience if anyone's thinking about doing it.

Highly recommend doing candy flipping from anecdotal experience if anyone's thinking about doing it. MDMA & LSD is my favorite combination (in the privacy of your own home with cozy safe surroundings and no external obligations for at least 2 days).

+1 the very best combo.
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