The main challenge in working with these high temperature plasmas is confinement. In order to achieve nuclear fusion matter needs to be heated to immense temperature, so that the kinetic energy of nuclei colliding can overcome the electrostatic force of the protons pushing each other away and "fuse" into larger nuclei (held together by the "strong force"), converting a fraction of the reaction mass into a relatively…
This is not exactly true. Inertial confinement fusion has conditions that are similar to stars. The engineering challenge for magnetically confined fusion to keep the low density plasma confined for long time durations for fusion.
For anyone interested in further reading, look up the Lawson Criterion.