However, as a framework author, I feel obliged to point out that of course you can create a more expressive and performant UI framework in a language with S-expressions, macros, and value semantics. What's hard is doing it in JavaScript. :)
It also feels a bit like reverse logic to cite ever-faster JavaScript VMs as a reason to choose a new framework for performance reasons -- shouldn't it matter less exactly how you structure your application logic when you're running on a "fusion reactor"? -- but I realize there's some subtlety here about lower constants enabling better algorithms. (Still, if your framework includes a language compiler or gets to take advantage of an expressive macro system, it should be able to run on anything.)
Once it's possible to compile ClojureScript without booting up a JVM -- which could happen if it becomes self-hosting -- I'll make a Meteor package for it. I'd also like to see the compile times get a little shorter and the runtime library get a little smaller.