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Creatine raises brain energy levels and slows cognitive decline: study

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Re: Creatine raises brain energy levels and slows cognitive decline: study

#111

Post by MilnerRoute »

What is TheSciVerse.org? The domain was registered 8 weeks ago. Although The Guardian also covered the study...

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More recently, attention has shifted beyond the gym. Early research suggests creatine could have a role in cognitive function, with some studies pointing to protection from cognitive decline.

“A few bigger studies have brought it into focus,” says [Bethan Crouse, a sports nutritionist at Loughborough University].

https://www.theguardian.com/lifeandstyle/2026/may/25/is-it-t...

Re: Creatine raises brain energy levels and slows cognitive decline: study

#112

Post by iwontberude »

ai_fry_ur_brain wrote: post #62
SoftTalker wrote: post #27

Earlier quoted context omitted.

I use it as a supplement because I do weightlifting. 5g/day. I did 20g/day for a week once, and didn't notice it made any difference, so I'm back to 5g now. In terms of stuff like memory, mood, etc. I can't say it's made any improvement but the idea that it might be helping prevent decline is nice.

Its changed my life. Im also a long time vegan with MTHFR gene mutations and sleep issues though.

That’s a pretty amazing acronym if real

Re: Creatine raises brain energy levels and slows cognitive decline: study

#114

Post by Auracle »

globular-toast wrote: post #96
amelius wrote: post #93

Earlier quoted context omitted.

Not what you want to hear, but genes, probably ...

Probably. Money seems to help too, though. A few Hollywood actors have miraculously reversed their male pattern baldness.

Hair transplants are probably affordable enough for 90% of people on HN.

Re: Creatine raises brain energy levels and slows cognitive decline: study

#115

Post by tom_ »

narmiouh wrote: post #22
bmmurphy wrote: post #8

The article's entirely AI-generated; not necessarily untrue but may not have been fully reviewed by an editor.

What did you use to determine this? Ask because many of the online tools I've tried, they will sometimes tag what I've written at 30-40% AI written and sometimes purely AI written stuff is flagged as 60-70% AI

"Quietly". Also, the first paragraph. If this wasn't actually 100% LLM generated, one has almost certainly been used to imbue it with the flavour.

Re: Creatine raises brain energy levels and slows cognitive decline: study

#116

Post by throwmeowaway »

ai_fry_ur_brain wrote: post #62
SoftTalker wrote: post #27

Earlier quoted context omitted.

I use it as a supplement because I do weightlifting. 5g/day. I did 20g/day for a week once, and didn't notice it made any difference, so I'm back to 5g now. In terms of stuff like memory, mood, etc. I can't say it's made any improvement but the idea that it might be helping prevent decline is nice.

Its changed my life. Im also a long time vegan with MTHFR gene mutations and sleep issues though.

I also have MTHFR gene mutations and sleep issues.

What exactly helped you?

Re: Creatine raises brain energy levels and slows cognitive decline: study

#118

Post by vidarh »

gardnr wrote: post #37
cj wrote: post #3

Direct link to the study: https://jpbs.hapres.com/htmls/JPBS_1766_Detail.html I wanted to check the dosages they used. Looks like the review includes studies ranging from 5g/day to 20-25g/day. (Typical dosage you'll see for daily use is 5 grams)

Just in case anyone is thinking about trying it: 25g seems pretty high. It’s worth it to review what that means for the rest of your body before starting this regime. Kidneys are really useful organs to have working.

I'm not aware of any evidence that creatine harms the kidneys if your kidney function is remotely normal. You'd probably want to check with your doctor if your kidney function is already compromised.

Creatine supplementation will freak out a lot of doctors if they're not warned of it ahead of time, though, and sometimes you'll even need to explain to them that they will see elevated levels of creatinine on the tests and it won't be an accurate predictor of kidney function.

If you're supplementing with creatine and need your kidneys tested it's easiest to stop a couple of weeks before, or ask for a Cystatin C test and make sure they use the relevant adjustments for body mass as well if you e.g. lift weights - I've more than once had doctors imply they were worried I had kidney disease because they were entirely unaware of the effects both creatine and large body pass has on the regular tests.

Re: Creatine raises brain energy levels and slows cognitive decline: study

#119

Post by tgv »

rzz3 wrote: post #98
tgv wrote: post #88

Earlier quoted context omitted.

19 patients completed, according to the article. And List Sorting, Oral reading, and Flanker only? The first and last are part of global and fluid composites, so those have to be excluded from comparison. That leaves us with 3 improved scores out of 12 tests. So 9 did not improve, or got worse. Figure 3 (of the original article) shows that the changes aren't big. Just "significant". Since the participants were in the…

Sounds like something we should study more rather than dismiss.

This study holds little promise at first sight. Remember that there is a lot to study, and only limited research capability.

> Sounds like something we should study more rather than dismiss.

Ignoring the implication of your use of "dismiss", why? How is this pilot promising?

Re: Creatine raises brain energy levels and slows cognitive decline: study

#120

Post by cobolcomesback »

zug_zug wrote: post #61
gardnr wrote: post #37

Earlier quoted context omitted.

Just in case anyone is thinking about trying it: 25g seems pretty high. It’s worth it to review what that means for the rest of your body before starting this regime. Kidneys are really useful organs to have working.

I can second this, do NOT start at 25g of creatine. If you're too lazy to read the literature a friendly AI tool will summarize it.

Most guidance I’ve seen says to start with a loading phase of 25-30g per day for several days, then go down to 5g per day maintenance.
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