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Peptides: where to begin?

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Re: Peptides: where to begin?

#111

Post by array_key_first »

cwmoore wrote: post #8
A_D_E_P_T wrote: post #2

Lowe has a point, but the FDA has painted itself into a corner by (a) forcing up the costs and the various bureaucratic demands associated with clinical trials, (b) allowing drug advertising , but then forcing those comical "may cause death" disclaimers, both of which have become totally ubiquitous, and (c) inconsistently following its own rules, and in some cases flouting its own rules. At this point, broscience is…

When medicine ignores nutrition entirely, and nutrient supplements are still complete unknowns, you have to wonder who the FDA is working for.

Medicine doesn't really ignore nutrition, but the problem is:

1. Most people don't believe it anyway. People want to hear they can eat hamburgers and milkshakes and be healthy. Telling them "we know that gives you heart disease and cancer" does nothing.

2. Nutrition is complicated and different for every person, because everyone has different things they can tolerate. The "perfect" diet is actually worthless because it has a 0% success rate. Really, we have to optimize for how miserable people are willing to be.

3. Most people are unhealthy enough that nutrition is the least of their concerns. That sounds crazy, I know, but if you're obese (which most people are!), then priority is being not obese. Not your nutrition. I know those sound related but they're way less related than you think.

Re: Peptides: where to begin?

#112

Post by olalonde »

rootusrootus wrote: post #101
olalonde wrote: post #57

Earlier quoted context omitted.

You lost muscle because you lost around 1.54% of body weight per week, which is way too aggressive. The maximum recommended amount for losing weight while retaining muscle is around 1%. You will also most likely experience a weight rebound.

Hasn't this mostly been debunked? You lose muscle mass because you lost mass overall, and whether you lost it too quickly or not is not the major factor. AFAIK maintaining muscle mass while losing fat is borderline impossible for anyone who isn't extremely fat and/or very disproportionate composition to begin with.

Not as far as I know. The ratio of fat-to-muscle loss depends on several factors, most notably the rate of weight loss (see https://pubmed.ncbi.nlm.nih.gov/34371981/). In fact, retatrutide is popular notably because it is known to preserve lean body mass better than other weight loss drugs.

Re: Peptides: where to begin?

#113

Post by hammock »

array_key_first wrote: post #111
cwmoore wrote: post #8

Earlier quoted context omitted.

When medicine ignores nutrition entirely, and nutrient supplements are still complete unknowns, you have to wonder who the FDA is working for.

Medicine doesn't really ignore nutrition, but the problem is: 1. Most people don't believe it anyway. People want to hear they can eat hamburgers and milkshakes and be healthy. Telling them "we know that gives you heart disease and cancer" does nothing. 2. Nutrition is complicated and different for every person, because everyone has different things they can tolerate. The "perfect" diet is actually worthless because…

> Most people don't believe it anyway

Maybe because so much of it is wrong, or (very charitably, as much is industry-biased) outdated?

Lifestyle modification is a definite challenge and I’m not dismissing it.

Still, hamburgers and milkshakes don’t give you heart disease and cancer. Overeating, oxidative stress from low-quality ingredients, etc might.

Re: Peptides: where to begin?

#114

Post by tbojanin »

twodave wrote: post #45
tbojanin wrote: post #21

I tried retatrutide for 10 weeks, here are my results: Before: 5'7, ~182lb Bench 1rm: 315 Squat: 5x10 225 Deadlift: 5x5 315 After: same height lol, 154lb Bench 1rm: 285 Squat: 5x10 205 Deadlift: 5x5 275 Suffered some anhedonia towards the end but that went away ~1wk after stopping. Overall pretty good, not any side effects. Definitely fixed my food craving problem. I didn't have a high intake of protein during the 10…

Did you work out during those 10 weeks any? TBH if you went from regular lifting to not for 10 weeks I'd expect a similar decrease in your lifting numbers (though not a .4lb/day weight loss of course)

I worked out 6 days a week still, but swapped out 1 of my leg days for a run day (between 2-4 miles)

Re: Peptides: where to begin?

#115

Post by [deleted] »

rootusrootus wrote: post #89
olalonde wrote: post #71

Earlier quoted context omitted.

Yes, I believe most people buy directly from somewhat shady Chinese factories. I tried contacting a few and they all refuse to meet or send samples from within China, so I assume what they're doing is illegal in China. In the US, it's legal to sell them as a "research chemical" but the FDA is cracking down on companies that are clearly engaging in b2c. There's this company that offers free testing: https://finnrick.c…

FWIW, finnrick's claim to fame is being free. Someone is paying for it. They have also failed blind tests in the past, Janoshik (IIRC) never has. There are several US-based labs but none of them have the same reputation as Janoshik.

[deleted]

Re: Peptides: where to begin?

#116

Post by tbojanin »

jwpapi wrote: post #98
tbojanin wrote: post #21

I tried retatrutide for 10 weeks, here are my results: Before: 5'7, ~182lb Bench 1rm: 315 Squat: 5x10 225 Deadlift: 5x5 315 After: same height lol, 154lb Bench 1rm: 285 Squat: 5x10 205 Deadlift: 5x5 275 Suffered some anhedonia towards the end but that went away ~1wk after stopping. Overall pretty good, not any side effects. Definitely fixed my food craving problem. I didn't have a high intake of protein during the 10…

solid bench brother

thank you:^)

Re: Peptides: where to begin?

#117

Post by tbojanin »

hammock wrote: post #46
tbojanin wrote: post #21

I tried retatrutide for 10 weeks, here are my results: Before: 5'7, ~182lb Bench 1rm: 315 Squat: 5x10 225 Deadlift: 5x5 315 After: same height lol, 154lb Bench 1rm: 285 Squat: 5x10 205 Deadlift: 5x5 275 Suffered some anhedonia towards the end but that went away ~1wk after stopping. Overall pretty good, not any side effects. Definitely fixed my food craving problem. I didn't have a high intake of protein during the 10…

Those are sizable drops for 10 weeks unless you stopped lifting as well

Mentioned above, but "I worked out 6 days a week still, but swapped out 1 of my leg days for a run day (between 2-4 miles)"

Re: Peptides: where to begin?

#118

Post by olalonde »

cjbgkagh wrote: post #78
olalonde wrote: post #36

The author is missing a massive segment of that gray market: people who buy FDA-approved weight loss drugs (e.g., semaglutide or tirzepatide) at 2–5% of the brand-name price. This route carries some risk, but there are ways to mitigate it, such as performing third-party testing. I assume most people who do this couldn't realistically afford the brand-name drug anyway, making this their only viable treatment.

I bought Semaglutide at 50c/mg and had it tested, it's the real deal. What's the normal price, $100/mg? My gf is in medicine so she had a friend test it through their work.

Last I checked, Ozempic (Semaglutide) is around $1000/month in the US. A typical 1 month pen is 4-8mg, so around $250/mg to $500/mg. So yeah, I may have understated how much cheaper the gray market version is.

Re: Peptides: where to begin?

#119

Post by jmye »

hammock wrote: post #113
array_key_first wrote: post #111

Earlier quoted context omitted.

Medicine doesn't really ignore nutrition, but the problem is: 1. Most people don't believe it anyway. People want to hear they can eat hamburgers and milkshakes and be healthy. Telling them "we know that gives you heart disease and cancer" does nothing. 2. Nutrition is complicated and different for every person, because everyone has different things they can tolerate. The "perfect" diet is actually worthless because…

> Most people don't believe it anyway Maybe because so much of it is wrong, or (very charitably, as much is industry-biased) outdated? Lifestyle modification is a definite challenge and I’m not dismissing it. Still, hamburgers and milkshakes don’t give you heart disease and cancer. Overeating, oxidative stress from low-quality ingredients, etc might.

> Still, hamburgers and milkshakes don’t give you heart disease and cancer. Overeating, oxidative stress from low-quality ingredients, etc might.

What? “Oxidative stress”? Oh come on, at least go full “seed oil” if we’re going to talk nonsense.

Re: Peptides: where to begin?

#120

Post by jmye »

tastyfreeze wrote: post #26
jmye wrote: post #7

Earlier quoted context omitted.

> Another point I could raise is that telemedicine has turned the entire prescription system into nothing more than a parasitic middleman/gatekeeper. I’m curious what you mean by this. I’m not sure what you mean by “prescription system” specifically.

Go to doctor, get prescription for restricted medicine, pick up prescription. If you can call up a teledoc and they give you a prescription based on your description why could you not just go buy the meds yourself without a prescription. You have essentially diagnosed yourself and just asked the doctor for permission to buy the drug you want.

That’s… not how actual telemedicine works. That’s how jackasses “disrupt” healthcare for very specific drugs. Mostly birth control, ED meds, and various hair regrowth meds.

It’s really clear that some of you are really mad about something you don’t understand.

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