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Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

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Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#111

Post by Loughla »

wafflemaker wrote: post #23
Loughla wrote: post #14

Earlier quoted context omitted.

I've tried everything and I still get panic attacks. I used to love smoking a small hitter about an hour before bed. I've always had insomnia and that was the one thing that actually helped me sleep. When it was illegal, I loved it. I would smoke 2 or 3 times a week just for sleep, and I was healthy and happy. . . Because sleep is important, and I never wanted to take sleeping pills because dependency. Now that it's…

Always thought that panic attacks were caused by too low CBD in regards to THC levels. Saw someone literally suggesting keeping a CBD vape pen just in case of a panic attack. Or a friend using it for heart palpitations. Wasn't the amount of THC concentration in resin seen as the indicator of potency? Then that amount was hacked through selective breeding, unbeknownst that not following with a complementary increase i…

So Charlotte's Web is super high CBD and extremely low THC. That's why I picked it. And it still makes me have anxiety attacks. It's very upsetting, as that was the one thing I could do to relax and sleep, and now even that is ruined.

Maybe it's just getting older? Who knows. I just wish I could get high a couple of times a week so that I sleep more than 2 or 3 hours.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#112

Post by DANmode »

Loughla wrote: post #108
DANmode wrote: post #55

Earlier quoted context omitted.

How low was the % of THC in the Charlotte’s Web? Full spectrum hemp (~0%) definitely feels like the answer, here!

It's like 0.3%. so pretty much as low as you can get while still having some THC. Does hemp have the same relaxing qualities?

Good hemp does.

Terpenes are the secret to cannabis.

Most cannabis has terpenes as a consequence.

Some cannabis has terpenes as a priority. This is the best cannabis.

The “essential oil” of the cannabis plant.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#113

Post by Loughla »

DANmode wrote: post #112
Loughla wrote: post #108

Earlier quoted context omitted.

It's like 0.3%. so pretty much as low as you can get while still having some THC. Does hemp have the same relaxing qualities?

Good hemp does. Terpenes are the secret to cannabis. Most cannabis has terpenes as a consequence. Some cannabis has terpenes as a priority. This is the best cannabis. The “essential oil” of the cannabis plant.

Any suggestions on the hemp or strains of THC? Hemp products make me kind of uncomfortable just because of the lack of regulation. God only knows what's in some of those things. Anyway, any brand recommendations?

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#114

Post by rolph »

Aurornis wrote: post #10

I only had time to skim the paper. Notably, the effect is concentration dependent and required high concentrations of THC. The chart shows it really starting in the 0.1uM range and then taking off in the 1uM range. I don’t know what levels are achieved during normal use but I did find some studies that successfully killed a lot of hippocampal neuronal cells after 6 days at 1uM range. So the levels of THC observed in…

quick back of the envelope:

this would require 3 joints of ~ 300 mg cannabis at ~ 30% THC content.

the legendary MTF strain regularily trumpets a 25-30% THC content.

now if bioavailability is 30% that means you need 9 or 10 joints to get a 1 micro molar total dosage. that dose is distributed across body mass.

at this point, i cant say i could conceive of anyone smoking basically an 1/8 ounce of MTA in one day, let alone at one sitting, and doing that for 6 days in a row sounds frightening, not recreational.

https://en.wikipedia.org/wiki/Tetrahydrocannabinol

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#115

Post by esperent »

smugtrain wrote: post #101
esperent wrote: post #25

Earlier quoted context omitted.

I have tried l-theanine, didn't do anything that I could tell. But fortunately there's a much better solution for those of us who get anxiety from weed, it's called "don't smoke weed".

Abstaining is not a cure for rude smugness, apparently

Nominative determinism via HN username. Your name has smug in it, and you go around seeing smugness where there is none intended. Sounds like a struggle but who am I to judge.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#116

Post by DANmode »

Loughla wrote: post #113
DANmode wrote: post #112

Earlier quoted context omitted.

Good hemp does. Terpenes are the secret to cannabis. Most cannabis has terpenes as a consequence. Some cannabis has terpenes as a priority. This is the best cannabis. The “essential oil” of the cannabis plant.

Any suggestions on the hemp or strains of THC? Hemp products make me kind of uncomfortable just because of the lack of regulation. God only knows what's in some of those things. Anyway, any brand recommendations?

Checked the brand I used to use when I needed it - they’re no longer selling hemp flower - just THC A.

Look for brands with lab tests that include terpene levels, and mycotoxins/solvents, for best results!

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#117

Post by thin_carapace »

johnisgood wrote: post #102
thin_carapace wrote: post #96

Earlier quoted context omitted.

it's truly a shame that wilful ignorance is societally acceptable. psychopathy is a scale we all fit on; everyone modulates their empathy to varying degrees, otherwise we'd be bonobos. the downtrodden of society deservedly get that moniker - for being walked over. im happy on your behalf that you are conscious enough to know how to treat yourself correctly, and it truly is a shame that others in your position aren't…

> either they have no clue what its like to hurt I was thinking the same thing. There is no way people who have chronic pain are saying these things. And if you think about it, it is sickening that people who are fine and do not have chronic pain are the ones dismissing a painkiller, or are trying to dictate someone else's life because they heard opiates are bad (opioid crisis, war on drugs). And yeah, everyone will…

people are lulled into believing that percieving an experience is equivalent to having experienced it themselves. western civilization has neutered the populace, but that doesnt change who the populace is, even if they deny it to themselves. c.f. vicarious by tool.

ive come to the point where straight up forcing people into church to be told they are selfish 1x a week is probably the best solution. if a secular version could exist id be all ears, frankly i dont care if god is real or not, people dont follow the commandments and society would be better off if everyone did.

i made a reddit account under this handle a little while back, although it was immediately banned. so i couldnt respond, but i could recieve your email address there and reach out myself.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#118

Post by aphunx »

rolph wrote: post #114
Aurornis wrote: post #10

I only had time to skim the paper. Notably, the effect is concentration dependent and required high concentrations of THC. The chart shows it really starting in the 0.1uM range and then taking off in the 1uM range. I don’t know what levels are achieved during normal use but I did find some studies that successfully killed a lot of hippocampal neuronal cells after 6 days at 1uM range. So the levels of THC observed in…

quick back of the envelope: this would require 3 joints of ~ 300 mg cannabis at ~ 30% THC content. the legendary MTF strain regularily trumpets a 25-30% THC content. now if bioavailability is 30% that means you need 9 or 10 joints to get a 1 micro molar total dosage. that dose is distributed across body mass. at this point, i cant say i could conceive of anyone smoking basically an 1/8 ounce of MTA in one day, let al…

[dead]

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#119

Post by johnisgood »

thin_carapace wrote: post #117
johnisgood wrote: post #102

Earlier quoted context omitted.

> either they have no clue what its like to hurt I was thinking the same thing. There is no way people who have chronic pain are saying these things. And if you think about it, it is sickening that people who are fine and do not have chronic pain are the ones dismissing a painkiller, or are trying to dictate someone else's life because they heard opiates are bad (opioid crisis, war on drugs). And yeah, everyone will…

people are lulled into believing that percieving an experience is equivalent to having experienced it themselves. western civilization has neutered the populace, but that doesnt change who the populace is, even if they deny it to themselves. c.f. vicarious by tool. ive come to the point where straight up forcing people into church to be told they are selfish 1x a week is probably the best solution. if a secular versi…

It doesn't seem like I can message you, so just send me an e-mail here: johnisbad@tutamail.com

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#120

Post by [deleted] »

riskassessment wrote: post #51
jcranmer wrote: post #41

Earlier quoted context omitted.

AIUI, all such results are because the FDA has given up since aduhelm and said "well, if it clears amyloid, that's as good as slowing Alzheimer's, right?" despite the actual results on Alzheimer's progression being largely negative.

For what it's worth, early statins were originally cleared based only on the evidence that they lower cholesterol without longer term studies showing a reduction in mortality. Of course there is now plenty of evidence showing statins improve overall endpoints.

[deleted]
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