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Enhancing gut-brain communication reversed cognitive decline in aging mice

med.stanford.edu

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Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#111

Post by dwood_dev »

WarmWash wrote: post #91
y-curious wrote: post #30

Earlier quoted context omitted.

What did you do for heartburn? Just looking for ideas. I noticed reducing gluten helped me personally a lot

I stopped taking esomeprazole after being on it for 4 years, and frequently had to supplement with famotidine and tums anyway. I had an infection and was prescribed antibiotics, and needed to pause the esomeprazole. I asked gemini about it and it suggested I take two probiotics while on the antibiotics, Saccharomyces boulardii and Lactobacillus rhamnosus GG. I noticed after a few days that I wasn't getting heartburn,…

There is a weak association with use of PPIs and memory loss. I myself noticed a difference once I stopped taking omeprazole regularly.

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#112

Post by wafflemaker »

zinkem wrote: post #28
inanutshellus wrote: post #9

Everyone's "poo-pooing" the article because the title doesn't mention mice, but, FWIW, stories of gut biota affecting humans behavior have been documented for a while. Memory gain is noteworthy, which is the article's "wow" factor, but everyone's just knee-jerk smirking so ... here's a few random articles to gross you out about the wild world of trading microbiota and, for better or worse, changing your personality:…

I believe this research is totally true-- I had a lot of memories come back after 1. I stopped drinking heavily and using other drugs, i.e. marijuana 2. managed my diet to avoid heartburn without medication 3. schedule my meals so it was easier to sleep at night (always eat something for breakfast when I wake up) I did not need any "poo infusion" or anything. I had a gal bladder removal that didn't fix the problems t…

The really crazy thing that happened to me when I changed diet to a more gut-biome friendly* is that (like I craved sweets before) I started craving vegetables and oatmeal. Like there was a regime change in my gut and the new guys pushed the buttons to get more of their food.

(less/no simple sugars, much more vegetables and starches/fibers, regularly eating 4 corn/20 plant oatmeal few times a week)

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#113

Post by wafflemaker »

throwawaytwit9 wrote: post #86
reverius42 wrote: post #73

Earlier quoted context omitted.

I'm a couple weeks into giving up coffee because of heartburn, and yeah, this tracks... unfortunately. I've replaced heartburn with heartache (having given up a beverage I've enjoyed daily for over 20 years).

Good luck, my friend. I’m right there with you. It’s not the physical effects but the rituals and the social connections that I miss. I felt the same with coffee as I did with smoking, which I quit about 20 years ago. It’s remarkable how much these simple vice shape our daily lives.

Yup. Discovered me and my dad have ADHD at pretty much the same time. In our case (very stimulant sensitive) we had to quit coffee to use ADHD meds. While I eventually switched to Inka (a roasted grain coffee substitute) when I saw how my heart results get better without coffee, he still struggles. He recently quit meds for some time due to unwanted symptoms and told me how he was away with some friends and deeply relished being able to normally drink coffee again.

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#114

Post by harry8 »

inanutshellus wrote: post #9

Everyone's "poo-pooing" the article because the title doesn't mention mice, but, FWIW, stories of gut biota affecting humans behavior have been documented for a while. Memory gain is noteworthy, which is the article's "wow" factor, but everyone's just knee-jerk smirking so ... here's a few random articles to gross you out about the wild world of trading microbiota and, for better or worse, changing your personality:…

"Reversing memory loss in mice via gut-brain communication"

And nobody is bothered by the story. And it gets less clicks. People get cranky when they have been suckered.

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#115

Post by skirmish »

behehebd wrote: post #34
seethishat wrote: post #13

IMO people should eat more fiber. A lot more fiber. It cleans the gut, the liver, absorbs cholesterol, slows insulin response and makes you feel full longer. The microbes in our guts need it to function. Rather than jumping from one fad diet to another, just eat what you like and be sure to get a lot of fiber each day.

To do this eat stuff that grows and not further processed.

Don't be simplistic. Mold on old bread grows and is natural, yet you should not eat it all day.

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#116

Post by frankzinger »

m463 wrote: post #102
ekaryotic wrote: post #40

Earlier quoted context omitted.

not the commenter but I bake my own soda bread and found that i was getting heartburn from the salt that was in the recipe. once i eliminated that i could eat as much as i wanted. I also cannot eat salt preserved potato chips on consecutive days.

I kind of wonder if sometimes acid reflux happens more than we realize, but we just notice it when spicy food comes up.

Pretty sure this is correct. You only notice it when it comes right out of the top. Other days it may be 25%, 50%, or 75% of the way up. And that's still bad for your oesophagus over the long term. My dad got cancer right at the bottom and one potential cause was chronic acid reflux (GERD leading to Barrett's eosophagus).

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#118

Post by SilentM68 »

That makes sense. I am of the opinion that the gut-brain connection exists. It is real in my view. A healthy gut promotes better mood and health. A parasite-ridden gut leads to all sorts of issues, including anxiety, irritability, stress, constipation and its counterpart, cancer and mental decline. I am doing a gut cleanse now to rebalance my intestinal flora and hopefully remove any bad actors from my gut resulting from years of ingesting processed foods. Want to make sure no parasites accompany me on my upcoming medical imaging visit.

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#119

Post by theshrike79 »

Aurornis wrote: post #72
theshrike79 wrote: post #44

"You" don't crave stuff, the microbiome in your intestine craves stuff. There are microbes in there that specialize in eating, say, sugar. You don't give them sugar, they send signals to your brain saying "yo, more sugar" This is why if you go on a sugar-free diet (just stop eating candy and sweets) the cravings just go away eventually. The microbes who keep shouting for more sugar either die away or go dormant.

If this was true, sugar cravings would disappear when taking antibiotics that kill those microbes. The fact that this doesn’t happen should give you pause about this woo-woo theory of cravings. The reason you crave sugar and fat and other tasty things is that they taste good. You evolved in a world where feeling rewarded and driven to consume more of these was beneficial to survival when food was scarce.

Antibiotics don't kill 100% of the gut biome, if it did so, we'd die.

It does some decimation, but not a full genocide.

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#120

Post by theshrike79 »

owenpalmer wrote: post #74
theshrike79 wrote: post #44

"You" don't crave stuff, the microbiome in your intestine craves stuff. There are microbes in there that specialize in eating, say, sugar. You don't give them sugar, they send signals to your brain saying "yo, more sugar" This is why if you go on a sugar-free diet (just stop eating candy and sweets) the cravings just go away eventually. The microbes who keep shouting for more sugar either die away or go dormant.

> "You" don't crave stuff False. We do crave stuff. The microbiome contributes to and influences cravings, but the way you're phrasing it is misleading.

True, I was kinda trying to allude that it's not the conscious you or your brain that craves things (usually), it's the gut/intestine flora sending the craving signals.
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