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Paracetamol disrupts early embryogenesis by cell cycle inhibition

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Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#111

There is mounting talk of a link between Paracetamol/Acetaminophen/Tylenol and autism. Some links: https://hsph.harvard.edu/news/using-acetaminophen-during-pre... https://jennifermargulis.substack.com/p/why-this-doctor-is-c...

It tends to be poor scholarship imho.

Autistic moms are more likely to have chronic illness, sensory issues, auto immune issues, etc thus are more likely to be taking medications. In the end, the autistic mom just passes her autistic genes to the baby.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#112
post #61

Earlier quoted context omitted.

That's why it's recommended to combine a half dose of ibuprofen and a half dose of paracetamol at the same time. (Plus some vitamin C) Together they have higher pain killung effects than each alone, and the side effects are reduced as they affect different body parts. And the vitamin C reduces the damage to the stomach lining.

Or if you need stronger painkilling you can take a full dose of paracetomol and either ibuprofen or aspirin. OTOH aspirin and ibuprofen use the same pathways so combining a full dose of ibuprofen and aspirin is not recommended.

Aspirin and ibuprofen are both NSAIDs with not too dissimilar pathways, so combining them won't be as effective as combining either with paracetamol. They'll both do their jobs, but if the ibuprofen is already doing its job, aspirin won't have much work left to do.

Meanwhile, taking ibuprofen can negate the effect aspirin has when taken against cardiovascular diseases. Not a huge problem if you're just taking it as a painkiller, but not everyone can combine the two. That's another potential reason to take paracetamol over some NSAIDs, though you should obviously consult a doctor if you're taking prescription medicine of any kind.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#113
post #20

[flagged]

Barely effective? The difference 20 minutes after my toddler takes a dose is astonishing.

It's also a very effective drug for reducing high fevers in infants and children.

There are legitimate reasons to complain about APAP but calling it a placebo is nonsense.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#114
post #42
post #18

I've always had an (unreasonable?) dislike of Paracetamol/Tylenol ever since I found out it was the #1 cause of acute liver failure in the US. Liver failure is scary. https://en.wikipedia.org/wiki/Paracetamol_poisoning

Most, if not all, medication would carry a poisonous symbol, if it were not taken out of regulation for that. Mostly, you kill organs by any overdose. Roughly: - Paracetamol overdose can cause severe liver damage and may be fatal. - Ibuprofen in high doses can lead to kidney injury and stomach bleeding. - Aspirin overdose may result in salicylate poisoning, causing ringing in the ears, confusion, and metabolic acidos…

- Metamizole has a tendency to kill some percentage of native Brits and their descendants. Yet globally it's one of the most popular painkillers, it's even OTC in countries with sufficiently low numbers of British and related people. (Has anyone ever done research to try and figure out why Brits are on the order of 1000x-10000x more sensitive to that side effect?)

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#115

There is mounting talk of a link between Paracetamol/Acetaminophen/Tylenol and autism. Some links: https://hsph.harvard.edu/news/using-acetaminophen-during-pre... https://jennifermargulis.substack.com/p/why-this-doctor-is-c...

A study published in JAMA in 2024 concluded that there is no evidence for that claim (https://jamanetwork.com/journals/jama/fullarticle/2817406):

Question: Does acetaminophen use during pregnancy increase children’s risk of neurodevelopmental disorders?

Findings: In this population-based study, models without sibling controls identified marginally increased risks of autism and attention-deficit/hyperactivity disorder (ADHD) associated with acetaminophen use during pregnancy. However, analyses of matched full sibling pairs found no evidence of increased risk of autism (hazard ratio, 0.98), ADHD (hazard ratio, 0.98), or intellectual disability (hazard ratio, 1.01) associated with acetaminophen use.

Meaning: Acetaminophen use during pregnancy was not associated with children’s risk of autism, ADHD, or intellectual disability in sibling control analyses. This suggests that associations observed in other models may have been attributable to confounding.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#116
I never took Tylenol/Paracetamol/acetaminophen, or anything containing it or given it to my children. We never reduce fever below 39.5/103.1 either - risks of febrile seizures are overstated and if you're a responsible parent, not a lazy one, you can see if things are going South, but there are other traditional means to lower fever. People are just too spoiled nowadays!

I tested positive with COVID-19 on Tuesday and had a pretty high fever (103) with a terrible headache, but I didn't take ibuprofen. First, because it could lower my fever, second, because its anti-inflammatory effect would compromise my immune system response to the pathogen. Most people I know immediately try to lower their fever to reduce their discomfort and would immediately take it for headaches, too.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#117
post #18

I've always had an (unreasonable?) dislike of Paracetamol/Tylenol ever since I found out it was the #1 cause of acute liver failure in the US. Liver failure is scary. https://en.wikipedia.org/wiki/Paracetamol_poisoning

I'm finding all the 'liver failure' comments on this post fascinating. The dose is on the back on the packet, as is the time interval between doses and the maximum number of pills per day. To overdose you need to ignore that. Given all the mention of 'Tylenol' I'm assuming most of the commenters are American - is this a thing in the US where you just take a random number of pills and ignore the labelling or treat it as a guide? Is it a consequence of the fact you can buy these in bottles by the hundred?

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#118

Earlier quoted context omitted.

Or if you need stronger painkilling you can take a full dose of paracetomol and either ibuprofen or aspirin. OTOH aspirin and ibuprofen use the same pathways so combining a full dose of ibuprofen and aspirin is not recommended.

Interesting, then why does Aspirin do almost nothing when I have a headache, while Ibuprofen works very well and very quickly?

Headaches have different causes.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#119
post #76
post #18

I've always had an (unreasonable?) dislike of Paracetamol/Tylenol ever since I found out it was the #1 cause of acute liver failure in the US. Liver failure is scary. https://en.wikipedia.org/wiki/Paracetamol_poisoning

This send me into a whole rabbit hole. Mostly children get paracetamol overdose. Then I learned that in US/UK kids get paracetamol in liquid form with all kinds of flavours. Which is much harder to dose correctly when the kid spits or drools it out. Total culture shock for me, as in Europe the default for children is rectal ingestion (which is probably a culture shock as well for Americans). Any how, with pills it is…

> as in Europe the default

There's no “as in Europe”, every European country is different. In France the default is also liquid form, but the pipette is graduated is kilograms of baby weight, which limit the errors you can make (you know your kid doesn't weight 15kg when his weight is around 8).

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#120
post #97

Earlier quoted context omitted.

[flagged]

Excedrin is the only thing besides morphine that cures my occasional but brutal headaches.

Do you happen to be a heavy coffee drinker? Caffeine withdrawal can cause immense pain, as I can confirm from first hand experience. For me, it starts ~24 hrs after the last coffee and it usually takes a very strong double espresso and a nap to get back to normal. Maybe Exedrin's Caffeine + Aspirin + Paracetamol has the same effect for you?
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