111–120 of 176 posts
How many people can really even afford life extension? As in living all the way into 90s or 100? Your retirement savings have to be pretty solid to enjoy those extra years. It’s not like before, the game has changed.
There's a fascinating tension with anti-aging drugs, which is that your preference would obviously be to take them as early as possible, so you spend more time at a younger age as opposed to just prolonging the last years of your life, where you'll be stuck in a nursing home anyway. But taking experimental drugs while you're young is also much higher risk, and you might see people sacrificing their 20s for the sake o…
Earlier quoted context omitted.
Is exercise really a maybe?
Even stuff like "don't be overweight" is a maybe. This meta-analysis famously found that being overweight actually has a moderate protective effect: https://pmc.ncbi.nlm.nih.gov/articles/PMC4855514/
Also overweight is not obese.
> Fast for short intervals regularly, and longer fasts as they feel good to you. You can effectively do this every day if you just eat once per day. When I was properly obese, this technique resulted in rapid weight loss. Zero exercise was required to see results, which was good at the time because the not eating part was about all I could handle. Being in a fasted state is as close as you can get to actually reversi…
Ascorbic is not a correct name of a compound. Should be 'ascorbic acid' or Vitamin C. Such sloppiness cast doubt on accuracy of the whole review.
Many of the studies he refers to are old. There was a widely held belief in the early 1980's promoted by Linus Pauling that Vit C cured cancer.
Ascorbic is not a correct name of a compound. Should be 'ascorbic acid' or Vitamin C. Such sloppiness cast doubt on accuracy of the whole review.
This, and the fact that Ascorbic acid leads to hardening of the arteries also makes it suspect. Many of the studies he refers to are old. There was a widely held belief in the early 1980's promoted by Linus Pauling that Vit C cured cancer.
Source?
Not about delaying the inevitable, but about undoing the accumulated damage of aging.
> Fast for short intervals regularly, and longer fasts as they feel good to you. You can effectively do this every day if you just eat once per day. When I was properly obese, this technique resulted in rapid weight loss. Zero exercise was required to see results, which was good at the time because the not eating part was about all I could handle. Being in a fasted state is as close as you can get to actually reversi…
Earlier quoted context omitted.
Taurine and Vitamin E are readily available and seem prudent. For melatonin, tryptophan plus niacin would maximize the serotonin pathway (note this is dangerous when used with SSRIs). How many of these are easily available? I had no idea that royal jelly is sold as a supplement.
Of the prescription options, estradiol is probably the most common and easily available, between hormonal birth control and HRT. It is also likely the most easy to study, as we have 60-70 years of usage that is not correlated with prevalence of other diseases that might skew life expectancy (like metformin etc.), and quite high-quality medical records by virtue of it being vended on a prescription basis. Despite this…
> Fast for short intervals regularly, and longer fasts as they feel good to you. You can effectively do this every day if you just eat once per day. When I was properly obese, this technique resulted in rapid weight loss. Zero exercise was required to see results, which was good at the time because the not eating part was about all I could handle. Being in a fasted state is as close as you can get to actually reversi…
Fasting without any exercise has a hidden downside: you’re not just burning fat, you’re also burning muscle. Less muscle → lower glucose disposal capacity → systemic insulin resistance. The problem is that insulin resistance doesn’t stop in muscle — the brain is highly insulin-sensitive, and once central insulin signaling gets disrupted you start seeing network-level dysfunction and cognitive impairment (there’s a re…