the economy depends on dopamine dysfunction in the VTA area i guess
GLP-1 drugs: An economic disruptor? (2024)
111–120 of 553 posts
Re: GLP-1 drugs: An economic disruptor? (2024)
#112I would feel like an absolute failure if I need medicine to help create willpower. EDIT: under the assumption of an average person who is not under any medical condition that may result in lack of willpower
Not as much as if such medicine weren’t available. ;)
Re: GLP-1 drugs: An economic disruptor? (2024)
#113I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…
> That late night trip to McDonalds will have you feeling like shit the next day
I've never had this reaction to fast food before. I only eat mcdonalds every few months and yea it's not the highest quality food, but I don't think there's anything in it to make you sick any more than other burger places have. I imagine you'd have to have restricted fast-food nutrition for quite some time before you feel a difference.
I'd like to see a study comparing people who ate mcdonalds who thought of it like slop vs those who saw it as a treat. I'm curious how much of this is psychosomatic, or how much of the craving for mcdonalds is rooted in feeling like crap in the first place.
(Granted, I've never had an issue with maintaining my appetite before, in fact I have issues keeping weight on, so I might have a fundamentally different relationship with food.)
Re: GLP-1 drugs: An economic disruptor? (2024)
#114> When companies like Google see their healthcare costs drop by $12,000 per employee annually and productivity increase by 25%, we observe a restructuring of corporate America that makes remote work a minor adjustment. In my entire office, there's one overweight person that I know. Out of thousands of employees. There could be more, and other cities might be different, but you get the idea. The author intentionally o…
40% of Americans are obese and way more are merely overweight. Either your office is small, a huge fluke, weirdly selected or you're not observant enough.
That 40% isn't evenly distributed.
Re: GLP-1 drugs: An economic disruptor? (2024)
#115I would feel like an absolute failure if I need medicine to help create willpower. EDIT: under the assumption of an average person who is not under any medical condition that may result in lack of willpower
Wasn't there an ADHD drug that was popular for hyper-productivity, in the years where being productive was all the hype?
Yeah. Amphetamines. All of those are drugs are like a scooby doo villain unmasking and amphetamines are underneath the mask.
Re: GLP-1 drugs: An economic disruptor? (2024)
#116Earlier quoted context omitted.
> Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to forget to eat. This is the largest of several reasons I hesitate to try it for myself. I am a very big guy (I would be about 184lbs if I had 0% bodyfat at my current musculature level). From the experiences I hear, I would not only struggle to have enough energy to…
I’ve been hyper aware of the muscle loss caveats and I think it’s the most important thing to know when starting the drug. You really need to prioritize protein intake and make sure your calorie deficit isn’t extreme. Losing too much weight too quickly, with or without the help of a drug, can be very unhealthy. I drink 4 protein shakes a day (160g total) in addition to regular food. If it weren’t for the protein shak…
> Then again, anyone who’s in a calorie deficit has lower energy.
Presumably if you're trying to lose weight, you have energy to burn you carry around with you. A calorie deficit doesn't imply lack of calories to burn. Presumably you're trying to trigger ketogenesis.
Granted, this is a lot less easy to access than simply eating simple carbs right before a workout and likely a lot less comfortable.
Re: GLP-1 drugs: An economic disruptor? (2024)
#117Wow. And this is the first generation of this class of drugs. Better drugs with fewer side effects are in the pipeline.
Maybe, or maybe not.
Drugs are not like a smartphone. There is no reason to believe you can improve on them (except on price)
Re: GLP-1 drugs: An economic disruptor? (2024)
#118Big food corporations profit from ultra-processed foods that manipulate our natural systems. They design products that override satiety signals using calculated combinations of sugar, fat and salt to activate brain dopamine pathways. Their priority is profit growth, not consumer health.
The consequences are significant health issues like obesity, diabetes and cardiovascular diseases. Healthcare systems struggle with preventable conditions while millions experience declining health and shorter lifespans. These corporations employ questionable strategies: marketing to children, lobbying against regulations, funding misleading research, and shifting responsibility to consumers.
Medications like Ozempic represent a threat to this model by reducing appetite and interrupting compulsive eating. Recent industry concerns about declining sales show how these medications could undermine their business approach. If consumers regain control over their eating habits, corporations may finally face consequences for practices that have profited from health problems for decades.
Re: GLP-1 drugs: An economic disruptor? (2024)
#119Earlier quoted context omitted.
Yes, up to 15 mg. Maintenance levels at 5, 10, and 15. If you cannot tolerate a maintenance level you can still get it, but insurance will not cover it ($1000/mo rather than $15/mo.) This is not an unreasonable situation. https://www.goodrx.com/zepbound/dosage
Luckily during the “shortage” you can currently get GLP-1’s in vials rather than injection pens. The brand name GLP’s you can’t control the dose. But when you get it in a vial from a compounding pharmacy you can inject however much or little you want. Not looking forward to ever using the brand name version specifically for this reason
The injection pen I have see has two marked dosages, but there is nothing stopping you from injecting more or less.
Basically it is a ratcheting mechanism where after ~10 clicks you get .25 mg dosage and 20 clicks gets you .50. Basically, no doctor is going to endorse it, but you can dial a dose to whatever amount you want.