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Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

nbcnews.com

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Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#111

Post by cynicalpeace »

Zelphyr wrote: post #98
cynicalpeace wrote: post #63

According to this article, it's been (sorta) reproduced once, which is better than most studies. About 40-60% of scientific studies are not reproducible. Given that, I'd want to see more reproductions. Also, I'm very annoyed by our American culture which tries to fix problems with drugs, rather than preventing them from happening in the first place with good diet, exercise, sleep and stress management.

I think the food manufacturers are culpable here, and "manufacturer" is really the best word to use. They're more like chemists cobbling together edible compounds than farmers growing things that provide nutrition.

Absolutely. And every time I come on HN to point out processed foods are bad, I always get the feigned confusion "But are cooked carrots a processed food"

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#112

Post by 93po »

throwaway041207 wrote: post #93
93po wrote: post #51

Earlier quoted context omitted.

do you have adhd, and do you think your drinking is at all related to adhd/lack of executive function? just curious, not implying.

I do not have ADHD. I am not sure exactly why I drink so much -- there are a number of alcoholics on both sides of my family, but I also spent many years drinking in bars in a big city, living a very social life. During COVID I became much more of a solitary drinker and over the last five or so years I have drank out of a sense of malaise. Every morning became the day I was going to take a break and every night there…

how long did you keep drinking after starting? thanks for response

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#113

Post by cynicalpeace »

Tokkemon wrote: post #74
cynicalpeace wrote: post #63

According to this article, it's been (sorta) reproduced once, which is better than most studies. About 40-60% of scientific studies are not reproducible. Given that, I'd want to see more reproductions. Also, I'm very annoyed by our American culture which tries to fix problems with drugs, rather than preventing them from happening in the first place with good diet, exercise, sleep and stress management.

These aren't preventative drugs, they are to treat people who are already fat.

Where did I say it was a preventative drug?

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#114

Post by cynicalpeace »

nemomarx wrote: post #66
cynicalpeace wrote: post #63

According to this article, it's been (sorta) reproduced once, which is better than most studies. About 40-60% of scientific studies are not reproducible. Given that, I'd want to see more reproductions. Also, I'm very annoyed by our American culture which tries to fix problems with drugs, rather than preventing them from happening in the first place with good diet, exercise, sleep and stress management.

A drug that reduces appetite is kinda tackling good diet, at least.

Keyword is "kinda"

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#115

Post by baq »

Tokkemon wrote: post #74
cynicalpeace wrote: post #63

According to this article, it's been (sorta) reproduced once, which is better than most studies. About 40-60% of scientific studies are not reproducible. Given that, I'd want to see more reproductions. Also, I'm very annoyed by our American culture which tries to fix problems with drugs, rather than preventing them from happening in the first place with good diet, exercise, sleep and stress management.

These aren't preventative drugs, they are to treat people who are already fat.

Looks like this is not exactly true given they reduce cravings.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#116

Post by bitcurious »

lawrenceyan wrote: post #57

Why not just lose weight by eating less? I know that sounds like a dumb question. But genuinely, aren’t you just paying money to… not spend the money on food instead?

“Why” is a weird question. We don’t know why. We do know that people don’t just eat less. Haven’t in decades. No plan that relies on changing that is practical.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#117

Post by cynicalpeace »

zpeti wrote: post #69
cynicalpeace wrote: post #63

According to this article, it's been (sorta) reproduced once, which is better than most studies. About 40-60% of scientific studies are not reproducible. Given that, I'd want to see more reproductions. Also, I'm very annoyed by our American culture which tries to fix problems with drugs, rather than preventing them from happening in the first place with good diet, exercise, sleep and stress management.

I agree with your sentiment, but frankly human nature just doesn’t work that way. We don’t have self control. We weren’t evolved for a world of abundance. This is no one’s fault, and it’s everywhere, china is getting fatter than most countries now. Realistically, ozempic is a miracle and it seems to be a solution to numerous issues of our world. It would be nice if it wasn’t so, but apart from the 10% of people who c…

I reject your assumption that "This is no one’s fault, and it’s everywhere, china is getting fatter than most countries now."

It's the food industrial complex's fault, along with many others (politicians, individuals without self control, etc)

I lived in rural Colombia for 4 years. People had access to the junk food, but it wasn't consumed very much because the veggies and meat are all produced locally and super tasty and cheap. And the local dishes were extremely meat and veggie based.

Oh, and most people know how to cook there.

It's not a fact of human nature to be unhealthy. It's a fact of modern culture.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#118

Post by kelseyfrog »

sandworm101 wrote: post #54
thepasswordis wrote: post #18

Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.

>> The number of things it apparently just cures is staggering. It cures behavior, not directly disease. I see red flags. Firefly did a movie about a drug that interfered with people's motivations to do things.

What evidence would it take to change your no-free lunch heuristic?

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#119

Post by fgimenez »

thepasswordis wrote: post #18

Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.

First-gen GLP-1 goes off patent in 2031 (e.g. semaglutide). Seems far off, but is frighteningly close for Novo. Tirzepatide gets genericized in 2039 and has better efficacy, which is why Lilly is in such a strong position right now.

There is an enormous amount of biotech work to develop next-gen versions that have better half-lives, lower adverse events, and most importantly, have long patent lives. But it seems base GLP-1 are good enough that we should see massive societal change starting next decade.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#120

Post by balthigor »

adventured wrote: post #61
loeg wrote: post #30

Earlier quoted context omitted.

Novo Nordisk's market cap is $500 B, mostly on the basis of GLP-1 drug profits, and the US' entire discretionary budget is $1,700 B. Even if Denmark would allow the sale, and even if somehow the US did not need to pay a premium to shareholders (typical in acquisitions), that would still be a very substantial expenditure.

That's not the way to go about it at all. The EU loves to ransom US tech companies for budget money. It's very clear that this is an opportunity for the US to similarly damage a big EU company by threatening its patents in the US, or otherwise hitting Novo for tens of billions of dollars in ransom money. The US market is by a huge margin the most important drug market in the world, and especially for Novo. Find an ab…

At this point in time, you are in no position to be teaching any lessons to the rest of the world, other than cautionary tales of wasted potential and the self-inflicted wounds of a belligerent populace.
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