Earlier quoted context omitted.
I guess it's important that the negative signal be relatively small compared to the affected system, like antivenom doses, but also it needs to be predictable/differentiable to some degree. If two different doses of venom never had the same molecular patterns then it would be impossible to immunize against it. A one-time supernova event would destroy a solar system, but the universe itself is antifragile to supernova…
Right. If you have systems that can adapt to stimulus in ways to prepare for recurring stimulus, you can look like this antifragile system. If the answer is to just be bigger... It is not a compelling model. So building your immunity by using low doses doesn't mean you are antifragile. It means you are trainable. And even then, you are within tolerance levels. And cannot ever withstand some poisons. Indeed, training…
For example, with the universe in relation to supernovas, we can say that a supernova wipes out a solar system. But new solar systems then take their place, with a different metal distribution that may be more conducive to advanced intelligence. If advanced intelligence is the goal, we might say that the universe is antifragile to supernovas, or more generally to the effects of gravity.
However, it's definitely a matter of perspective given that supernovas themselves are entirely inconsequential to the universe as a whole, and are only relevant to subsystems at specific emergent layers within the universe.
We could also form similar conclusions about natural evolution in general.
We might even be able to generalize further and posit that there is a natural tendency for order to arise out of chaos, and so order itself is antifragile to chaos, given that order thrives under the right chaotic conditions[0] and isn't simply immunized against it. So antifragility may exist as a fundamental property of the foundation of stuff, but it's not automatically an inheritable property of subsystems.
It all becomes very abstract, but at least we can define some constraints, namely that antifragility should be described in terms of optimization goals and measurement of specific states, and are thus subjective to the observer and not an innate property of the universe or any other system.