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Psilocybin desynchronizes the human brain

nature.com

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Re: Psilocybin desynchronizes the human brain

#111
post #12

While the analogies are often useful, everyone reading HN comments should be very aware and very skeptical of just how often computer/tech people rely on computer/tech analogies to understand things that are fundamentally not computers/tech. It is very very easy for smart people with functionally specific jobs/hobbies/ways of thinking to see all reality through that narrow window. It often leads to important details…

> You can start feeling like you KNOW big sweeping Truths. Yep. During a pretty bad episode of delusional schizophrenia (for lack of any better diagnosis) I had that, many years ago. I felt like I was either on the verge of a huge epiphany or I'd just had one, for a few weeks. Every time it was nonsense or couldn't be explained. Luckily I have not relapsed and I have been off the antipsychotics for a few years The on…

[deleted]

Re: Psilocybin desynchronizes the human brain

#112

PSA: My buddy shot himself in the head while we were on shrooms in our twenties. He thought he meant God, took a shower picked up a gun and shot himself in the head. While I've had trips since then and do get benefits from those experiences. People without experience should be careful, especially if you have a history of mental illness. He did have a history to some degree but not overtly.

Part of the lesson of this story is the danger of having a gun in the home at all. He could have been sober and depressed and did the same just as easily thanks to having access to a gun. There's a lot of statistical evidence for how dangerous situations like depression or domestic violence can become once a gun is nearby.

Your first statement is not supported by the second. Yes, in a DV situation or a situation where someone has severe mental illness, it's probably not a good idea to have easy access to a firearm.

But if you actually look at the numbers, the average firearm is not used in self-defense, nor is it used to endanger a family member. The vast majority just . . . sit there. They're machines which must be used respectfully and responsibly, not magic evil talismans.

Re: Psilocybin desynchronizes the human brain

#113

Earlier quoted context omitted.

Sources?

Anecdotal, but I've tripped with two people who showed seizure like symptoms that they never had before or since. Couldn't find any data at the time. Tried to get them to submit experience reports on erowid so that there would be some data out there, but they didn't want to put anything about it in writing.

ok - an underweight 20 year old woman who did not eat well before a Rolling Stones concert and then used cocaine and alcohol, also had a seizure.

goddam Mick Jagger !

Re: Psilocybin desynchronizes the human brain

#114

>Healthy adults were tracked before, during and for 3 weeks after high-dose psilocybin (25 mg) and methylphenidate (40 mg), and brought back for an additional psilocybin dose 6–12 months later. Not simultaneously I hope.. that sounds like it would be a rough ride

"it can generally be assumed that there is approximately 15 mg (+/- 5 mg) of psilocybin per gram of dried mushroom" -Wikipedia So 25mg is ~1.5g of dried mushrooms. Decent dose, but not a "omg I'm one with the universe." For instance, a "Hero Dose" typically starts at 5g of dried mushrooms, so ~3x the dosage used in the study. Though it's possible the uptake rate using their dosing mechanism is much higher than "stoma…

some kinds of mushrooms can grow tolerance fairly quickly, also.. based on info from a friend

Re: Psilocybin desynchronizes the human brain

#115

Earlier quoted context omitted.

Part of the lesson of this story is the danger of having a gun in the home at all. He could have been sober and depressed and did the same just as easily thanks to having access to a gun. There's a lot of statistical evidence for how dangerous situations like depression or domestic violence can become once a gun is nearby.

Your first statement is not supported by the second. Yes, in a DV situation or a situation where someone has severe mental illness, it's probably not a good idea to have easy access to a firearm. But if you actually look at the numbers, the average firearm is not used in self-defense, nor is it used to endanger a family member. The vast majority just . . . sit there. They're machines which must be used respectfully a…

> The vast majority just . . . sit there.

This is irrelevant to the statement that having a gun around is more dangerous than not having a gun around.

https://med.stanford.edu/news/all-news/2020/06/handgun-owner...

https://med.stanford.edu/news/all-news/2022/04/handguns-homi...

Re: Psilocybin desynchronizes the human brain

#116

Earlier quoted context omitted.

Part of the lesson of this story is the danger of having a gun in the home at all. He could have been sober and depressed and did the same just as easily thanks to having access to a gun. There's a lot of statistical evidence for how dangerous situations like depression or domestic violence can become once a gun is nearby.

Your first statement is not supported by the second. Yes, in a DV situation or a situation where someone has severe mental illness, it's probably not a good idea to have easy access to a firearm. But if you actually look at the numbers, the average firearm is not used in self-defense, nor is it used to endanger a family member. The vast majority just . . . sit there. They're machines which must be used respectfully a…

Yet it remains true that not having magic evil talismans in my house makes it very unlikely that my family or I get cursed by accident.

Re: Psilocybin desynchronizes the human brain

#117

Earlier quoted context omitted.

Part of the lesson of this story is the danger of having a gun in the home at all. He could have been sober and depressed and did the same just as easily thanks to having access to a gun. There's a lot of statistical evidence for how dangerous situations like depression or domestic violence can become once a gun is nearby.

Your first statement is not supported by the second. Yes, in a DV situation or a situation where someone has severe mental illness, it's probably not a good idea to have easy access to a firearm. But if you actually look at the numbers, the average firearm is not used in self-defense, nor is it used to endanger a family member. The vast majority just . . . sit there. They're machines which must be used respectfully a…

> if you actually look at the numbers, the average firearm is not used in self-defense

Those aren't really the numbers you'd want to look at, right? If you have a community with 1000 firearms and 499 of them end up being used in a shooting you could still assert that "most firearms are never used".

I think what you'd care about in assessing risk is: what is the likelihood of violent injury and/or death in household with firearms vs households without? Controlled for other relevant factors?

I've never seen this particular assessment presented in the way I've described it, but then again it sounds like there are some political hurdles to studying gun violence: https://abcnews.go.com/US/federal-government-study-gun-viole...

Re: Psilocybin desynchronizes the human brain

#118

Earlier quoted context omitted.

Part of the lesson of this story is the danger of having a gun in the home at all. He could have been sober and depressed and did the same just as easily thanks to having access to a gun. There's a lot of statistical evidence for how dangerous situations like depression or domestic violence can become once a gun is nearby.

Your first statement is not supported by the second. Yes, in a DV situation or a situation where someone has severe mental illness, it's probably not a good idea to have easy access to a firearm. But if you actually look at the numbers, the average firearm is not used in self-defense, nor is it used to endanger a family member. The vast majority just . . . sit there. They're machines which must be used respectfully a…

Most landmines also just sit there.

Re: Psilocybin desynchronizes the human brain

#119

I can't think of anything in the world I would enjoy doing less than completing "a simple auditory–visual matching task" while in an MRI scanner on shrooms.

The set and settings researchers typically use for usual psych studies are going to bias psychedelic results so much. Think that building you hated in undergrad's crusty unlit cinderblock basement with no windows but coated in cameras and microphones. Its so dystopian, you are literally a caged rat. I don't think you can perform this research in good faith without having experienced a proper trip yourself. It's just…

I would suggest the world needs more Shulgins as well.

https://en.wikipedia.org/wiki/Alexander_Shulgin

Re: Psilocybin desynchronizes the human brain

#120

I can't think of anything in the world I would enjoy doing less than completing "a simple auditory–visual matching task" while in an MRI scanner on shrooms.

Indeed, the best setting is in nature on a beautiful day

Or a beautiful star filled night.
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