Shout out to https://virt-manager.org/ - works much better for me, supports running qemu on remote systems via ssh. I used to use this all the time for managing bunches of disparate vm hosts and local vms.
Yes, they have some additional useful administration features like start/stop based on a config file, serial console access, but these are really simple to implement in your own shell scripts. Storage handling in libvirt is horrible, verbose, complex, yet it can't even work with thin LVs or ZFS properly.
Unless you just want to run stuff the standard corporate way and do not care about learning fundamental software like qemu and shell, or require some obscure feature of libvirt, I recommend using qemu on KVM directly, using your own scripts. You'll learn more about qemu and less about underwhelming Python wrappers, and you'll have more control on your systems.
Also, IBM/Red Hat seems to have deprecated virt-manager in favour (of course) a new web interface (Copilot).
Quickemu seems to be of more interest, as it allows launching new VM right after a quick look at examples, without time wasting on learning a big complicated UI.