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Scientists discover links between Alzheimer's disease and gut microbiota

kcl.ac.uk

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Re: Scientists discover links between Alzheimer's disease and gut microbiota

#111

If you look at the scatter graphs, it's not terribly impressive. Lots of overlap, and most of the results show no difference. The one that does show a large difference still has a lot of overlap in the scatter graph, and it seems to be some outliers that bring down the mean value. It's kind of an extraordinary claim, which requires extraordinary evidence. This isn't that. What interests me more is why HN users keep p…

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Re: Scientists discover links between Alzheimer's disease and gut microbiota

#112
I wonder if simply taking antibiotics at some point, clearing everything out and repopulating the flora could help?

My guess is no - that something in the system is triggered by the fecal transplant but that gut flora isn't the main source, but it would be an interesting thing to look at. I'm not in this field and do not know how to mine this data or properly posit the question, but maybe something along the lines of: "How many people who have taken a strong antibiotic in the last 10 years get alzheimer's vs people who have not taken any antibiotics?" Seems like this data should be out there, right?

Maybe someone who works with this kind of data or research can weigh in. Can you imagine if the cure is that simple? Just take strong antibiotics at an early stage....!?!

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#113
Are shady fecal transplant clinics a thing yet? Take these antibiotics for a week, then we’ll hose fecal matter from healthy, young, thin people into your intestines like a reverse enema. Move over sperm banks and blood banks, the poop bank is much easier. Only sorta joking.

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#114

I wonder if simply taking antibiotics at some point, clearing everything out and repopulating the flora could help? My guess is no - that something in the system is triggered by the fecal transplant but that gut flora isn't the main source, but it would be an interesting thing to look at. I'm not in this field and do not know how to mine this data or properly posit the question, but maybe something along the lines of…

N=1. I had various digestion problems, probably due to gut flora imbalances. After several years of trying to fix the problem with diet changes suggested by my doctor (more fiber), I traveled abroad and came home with a very nasty food borne illness.

After one Z-pack and several days of being "backed up", my gut was suddenly back to normal and has been fine since.

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#115

Are shady fecal transplant clinics a thing yet? Take these antibiotics for a week, then we’ll hose fecal matter from healthy, young, thin people into your intestines like a reverse enema. Move over sperm banks and blood banks, the poop bank is much easier. Only sorta joking.

[deleted]

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#116

I wonder if simply taking antibiotics at some point, clearing everything out and repopulating the flora could help? My guess is no - that something in the system is triggered by the fecal transplant but that gut flora isn't the main source, but it would be an interesting thing to look at. I'm not in this field and do not know how to mine this data or properly posit the question, but maybe something along the lines of…

> I wonder if simply taking antibiotics at some point, clearing everything out and repopulating the flora could help?

For some GI issues, this is actually a real solution used today. I learned about it from a SIBO diagnosis, which is treated with antibiotics and dietary changes. https://en.wikipedia.org/wiki/Small_intestinal_bacterial_ove...

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#117

I wonder if simply taking antibiotics at some point, clearing everything out and repopulating the flora could help? My guess is no - that something in the system is triggered by the fecal transplant but that gut flora isn't the main source, but it would be an interesting thing to look at. I'm not in this field and do not know how to mine this data or properly posit the question, but maybe something along the lines of…

Fecal transplants are used to repopulate the gut of someone when necessary - for example after strong antibiotics! You can use flora of someone living in your household, as you probably share a lot of flora by being in the same environement and sharing food.

Edit0: Not "you can use" as in "do this at home" but in the sense of "it's an option your healthcare provider might offer. I worded it odd.

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#118

I wonder if simply taking antibiotics at some point, clearing everything out and repopulating the flora could help? My guess is no - that something in the system is triggered by the fecal transplant but that gut flora isn't the main source, but it would be an interesting thing to look at. I'm not in this field and do not know how to mine this data or properly posit the question, but maybe something along the lines of…

N=1. I had various digestion problems, probably due to gut flora imbalances. After several years of trying to fix the problem with diet changes suggested by my doctor (more fiber), I traveled abroad and came home with a very nasty food borne illness. After one Z-pack and several days of being "backed up", my gut was suddenly back to normal and has been fine since.

Rebooting fixes so many problems.

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#119
post #117

I wonder if simply taking antibiotics at some point, clearing everything out and repopulating the flora could help? My guess is no - that something in the system is triggered by the fecal transplant but that gut flora isn't the main source, but it would be an interesting thing to look at. I'm not in this field and do not know how to mine this data or properly posit the question, but maybe something along the lines of…

Fecal transplants are used to repopulate the gut of someone when necessary - for example after strong antibiotics! You can use flora of someone living in your household, as you probably share a lot of flora by being in the same environement and sharing food. Edit0: Not "you can use" as in "do this at home" but in the sense of "it's an option your healthcare provider might offer. I worded it odd.

C Diff was in a recent Southpark Episode: https://www.youtube.com/watch?v=ENEBRFOVuXI

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#120

Earlier quoted context omitted.

N=1. I had various digestion problems, probably due to gut flora imbalances. After several years of trying to fix the problem with diet changes suggested by my doctor (more fiber), I traveled abroad and came home with a very nasty food borne illness. After one Z-pack and several days of being "backed up", my gut was suddenly back to normal and has been fine since.

Rebooting fixes so many problems.

Just don't reboot every year, or multiple times per year.

You can cause worse issues than you started with!

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