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Gut microbe linked to depression in large health study

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Re: Gut microbe linked to depression in large health study

#111

Post by aussieguy1234 »

Shank wrote: post #79
dan353hehe wrote: post #63

Earlier quoted context omitted.

I was skeptical of this when I first heard of it several years ago. It sounded just like every other popular diet does: “Just (don’t) eat this certain food, and you will feel amazing!” But I have several family members on it right now, and they all report feeling WAY better. And this is after years of dealing with IBS type problems too.

Low FODMAP works, but it’s precisely because it’s unlike all other “diets”. It’s a systematic removal of basically all short-chain sugars. The problem with it, as someone who was instructed to follow it, is that it’s extremely unintuitive to know what foods are low or high FODMAP without the list. Because of this, it’s really easy to make mistakes unless you consult the list prior to eating. So it definitely gives po…

Yep, there are hundreds of foods out there that have them.

Personally I use this app when eating anything I'm not sure about, it has a database of foods and their fodmap content: https://www.monashfodmap.com/ibs-central/i-have-ibs/get-the-...

Re: Gut microbe linked to depression in large health study

#112

Post by thenerdhead »

cesnja wrote: post #97
thenerdhead wrote: post #87

I've seen these studies time and time again. I do wonder what are the practical steps one takes to "repair" or "renew" their gut? I'm not a fan of drugs being the cure. In fact, I don't think they are the first solution people should hope for or supplement with unless it's not practical to get them in a natural way. I feel like we see more and more gut related issues due to depression & depression's little cousin anx…

> what are the practical steps one takes to "repair" or "renew" their gut? Look up nutritionfacts.org and read/view it with a generous pinch of salt. A few years ago it took me half a year to switch to a mostly WFPB diet advertised there and I had no issues whatsoever. My gut is now more resilient, I remember having problems with bloating and/or diarrhea if I ate just a bit more fiber some days. > why aren't we focus…

This dude sounds like Jeff Goldblum. Thanks for the recommendation!

Re: Gut microbe linked to depression in large health study

#113

Post by antiterra »

potatoman22 wrote: post #75
antiterra wrote: post #64

Earlier quoted context omitted.

I’m curious, why do you think that?

Playing devil's advocate, do we have any reason to believe that people who are genetically more succeptible to depression aren't also more likely to have this sort of gut via genetics? That would result in this correlation. Perhaps improving your gut biome wouldn't actually help with depression?

If people with depression have this sort of gut, that still doesn’t establish directional cause or mechanism.

The semi-autonomous nervous system in our guts, the microbes in our guts, and our central nervous system have complex chemical signaling interactions. Neurotransmitters linked to effects on mood are generated by the gut. Therefore, the brain can signal to the gut that it should release neurotransmitters, and the gut can release those neurotransmitters itself.

Because of this interaction, it’s possible the ‘culprit’ for depression is behavior by the brain, microbes on the gut, the gut itself, or the brain-gut interaction (Or any combination of the four.)

A good summary of our understanding of these mechanisms is at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772764/

Re: Gut microbe linked to depression in large health study

#114

Post by sdze »

jwuphysics wrote: post #105
zackmorris wrote: post #99

Just another data point, but my journey through digestive issues and recovery was kicked off by the worst depression and burnout I ever experienced, which started in 2019 and lasted 3 years. My best guess for what happened is that work stress, excessive celebration and coping with the cognitive dissonance of the pre-COVID era and subsequent pandemic, combined with overtraining and the misuse of protein shakes in plac…

I'm sorry to hear about your experiences and it sounds like you learned a lot from firsthand knowledge. But, respectfully asking, what does inflammatory foods or poor eating habits have to do with GMO foods?

Also why would GMO be bad? The criticism comes mostly from people that also believe in osteopathic / homeopathic medicine in my social circle.

I find it a terrific chance for humanity to engineer plants in such a way that they are more robust against disease and bad weather (with CRISPR/CAS and such methods).

Re: Gut microbe linked to depression in large health study

#115

Post by zabzonk »

wutbrodo wrote: post #104
zabzonk wrote: post #69

> Thus, the newest study seems to be “further proof” that inflammation caused by gut microbes can influence mood Of course it bloody can - if you have IBS or any number of other gut-related problems, believe me you are very likely to be depressed, because the symptoms of these are very nasty and humiliating. This does not mean that the bacteria are directly affecting the CNS. Also: > Kiebdiella It's Klebsiella

It seems pretty obvious from reading the article in its entirety that the claim is that the inflammation is affecting mood directly, not via nasty and humiliating gastro symptoms.

How would you differentate between the two?

Re: Gut microbe linked to depression in large health study

#116

Post by rogers18445 »

sdze wrote: post #114
jwuphysics wrote: post #105

Earlier quoted context omitted.

I'm sorry to hear about your experiences and it sounds like you learned a lot from firsthand knowledge. But, respectfully asking, what does inflammatory foods or poor eating habits have to do with GMO foods?

Also why would GMO be bad? The criticism comes mostly from people that also believe in osteopathic / homeopathic medicine in my social circle. I find it a terrific chance for humanity to engineer plants in such a way that they are more robust against disease and bad weather (with CRISPR/CAS and such methods).

Currently there doesn't appear to be any evidence that GMO is bad for your health and most GMO is just transplanting genes from other edible organisms.

Hopefully regulators aren't going to allow insertion of engineered genes producing novel molecules without going through actual medical grade trials for those molecules. Or it may torpedo the entire industry.

Re: Gut microbe linked to depression in large health study

#117

Post by manmal »

jwuphysics wrote: post #105
zackmorris wrote: post #99

Just another data point, but my journey through digestive issues and recovery was kicked off by the worst depression and burnout I ever experienced, which started in 2019 and lasted 3 years. My best guess for what happened is that work stress, excessive celebration and coping with the cognitive dissonance of the pre-COVID era and subsequent pandemic, combined with overtraining and the misuse of protein shakes in plac…

I'm sorry to hear about your experiences and it sounds like you learned a lot from firsthand knowledge. But, respectfully asking, what does inflammatory foods or poor eating habits have to do with GMO foods?

Not OP. In many cases, the genetic modifications are either performed to either let the plant produce (more) lectins that kill insects, or make the plant immune to certain herbicides like glyphosate. The human gut and microbiome might be able to deal with lectins they have evolved to deal with, and in “normal” quantities. But those additional GMO lectins are suspected to be hard on the intestinal barrier. If that barrier is compromised, autoimmunity might be the result, as OP indicated.

Re: Gut microbe linked to depression in large health study

#118

Post by netizen-936824 »

rogers18445 wrote: post #116
sdze wrote: post #114

Earlier quoted context omitted.

Also why would GMO be bad? The criticism comes mostly from people that also believe in osteopathic / homeopathic medicine in my social circle. I find it a terrific chance for humanity to engineer plants in such a way that they are more robust against disease and bad weather (with CRISPR/CAS and such methods).

Currently there doesn't appear to be any evidence that GMO is bad for your health and most GMO is just transplanting genes from other edible organisms. Hopefully regulators aren't going to allow insertion of engineered genes producing novel molecules without going through actual medical grade trials for those molecules. Or it may torpedo the entire industry.

In every case of GMO food I have encountered, the compounds are not novel. Rather, they're an adaptation or resistance found in one species and transferred to another.

Re: Gut microbe linked to depression in large health study

#119

Post by rjsw »

sdze wrote: post #114
jwuphysics wrote: post #105

Earlier quoted context omitted.

I'm sorry to hear about your experiences and it sounds like you learned a lot from firsthand knowledge. But, respectfully asking, what does inflammatory foods or poor eating habits have to do with GMO foods?

Also why would GMO be bad? The criticism comes mostly from people that also believe in osteopathic / homeopathic medicine in my social circle. I find it a terrific chance for humanity to engineer plants in such a way that they are more robust against disease and bad weather (with CRISPR/CAS and such methods).

As someone else with immune system reactions to food, it doesn't seem a great idea to modify food even more than we have done already.
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