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Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

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Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#111

Post by ahstilde »

TheBlerch wrote: post #72
ahstilde wrote: post #70

Earlier quoted context omitted.

Thank you! Patients see improvement in symptoms after 6 months, with some patients reporting improvement as soon as 6 weeks. For most patients, this means they can stop taking their antihistamines. You mentioned inhalers. While there has been connection between allergy immunotherapy and asthma, allergy immunotherapy is not a replacement for your asthma inhaler. If a patient stays on drops for 5 years, they can expect…

Thank you for the info, which I'll gladly share with friends and family that are sufferers. What determines when the user has achieved relief and can stop the drops treatment? What data or tests allows Wyndly to know if a user has achieved relief in 2, 3 or 5 years?

Patients experience relief when they no longer have allergy symptoms.

Here are some research papers you can share:

Long-lasting effects of sublingual immunotherapy according to its duration: a 15-year prospective study https://pubmed.ncbi.nlm.nih.gov/20934206/

Efficacy and Safety of Subcutaneous and Sublingual Immunotherapy for Allergic Rhinoconjunctivitis and Asthma https://pubmed.ncbi.nlm.nih.gov/28964530/

Clinical improvement after escalation for sublingual immunotherapy (SLIT) https://pubmed.ncbi.nlm.nih.gov/21938688/

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#113

Post by brogrammernot »

jakartaexpress wrote: post #94

YC startups are becoming scum bags day by day. Can you address this? If your treatment is faulty, why do I need to give up my rights? Binding Arbitration. These Terms of Use provide that all disputes between you and Wyndly Health that in any way relate to these Terms of Use or your use of the Site will be resolved by BINDING ARBITRATION. ACCORDINGLY, YOU AGREE TO GIVE UP YOUR RIGHT TO GO TO COURT (INCLUDING IN A CLAS…

Pretty harsh and uncalled for feedback that’s not constructive at all.

Calling them scumbags because of their T&Cs instead of asking for why they have such language in there is counterproductive in any civil conversation.

Maybe there’s precedence they’re following or it was an overzealous lawyer writing it and they haven’t taken a second look because you know, getting a business off the ground is hard work.

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#114

Post by mananatwyndly »

mrfusion wrote: post #75

So how does a vaccine train your body to attack an antigen but allergy shots/drops do the opposite?

It actually works in a very similar fashion. Both vaccines and allergy drops change the immune system and create antibodies. In the case of vaccines, your body creates antibodies that bind to the virus to prevent them from causing symptoms of the virus (sickness/illness).

For allergy shots/drops your body also makes antibodies to bind to the allergens and prevent them from causing symptoms of the allergens like sneezing or nasal congestion. So both work in a similar mechanism. The challenge with allergy drops and allergy shots is the clinical data shows that it takes a much longer time for your body to create an immune system change that decreases your allergy symptoms than it does for your body to create antibodies to block a virus. Does this make sense?

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#115

Post by mananatwyndly »

WaitWaitWha wrote: post #59
mananatwyndly wrote: post #30

Earlier quoted context omitted.

The good news is the risk of anaphylactic shock with allergy drops is incredibly low. The literature cites that risk as 1/billion or 1/100 million which is thankfully very low. Indeed, in 30 years of using allergy drops there has never been a documented reaction that caused a death. Like I do for all of my in office patients that also take at home allergy drops we always educate our patients thoroughly about the risk…

I need a bit more clarification to > .. risk of anaphylactic shock with allergy drops is incredibly low. The literature cites that risk as 1/billion or 1/100 million which is thankfully very low. Indeed, in 30 years of using allergy drops there has never been a documented reaction that caused a death. Can you point me to the specific literature? The reason I am asking as the Asthma & Allergy Foundation of USA states…

Absolutely, one great paper that summarizes many of the studies is the Cochrane review. They are an independent scientific body focussed on evidence based medicine. You can read the Cochrane review article on sublingual immunotherapy here:

https://pubmed.ncbi.nlm.nih.gov/21154351/

Another paper discussing the safety of sublingual immunotherapy can be found here:

Sublingual allergen immunotherapy: mode of action and its relationship with the safety profile https://pubmed.ncbi.nlm.nih.gov/22150126/

That number is from the line "SLIT-induced anaphylaxis equate to around one case per 1000 million SLIT administrations or per 526,000 treatment years'.

Another nice review paper can be found here:

https://pubmed.ncbi.nlm.nih.gov/28964530/

Hope this helps!

Manan

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#116

Post by dang »

jakartaexpress wrote: post #96
alexanderrofail wrote: post #11

This sounds incredible.

It’s not. There are literally hundreds doing same thing. They also use arbitration. Looks like you are paid commenter. My bad!

You can't accuse another user like that. We ban such accounts. Please read the site guidelines and don't do it again.

https://news.ycombinator.com/newsguidelines.html

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#118

Post by jjcon »

borski wrote: post #100

Genuine question: there are already many others doing this, including online. For example: https://myallergydrops.com/ https://www.allergyeasy.com/ How do you folks differentiate?

Considering that first link just has big buck bunny for all their videos and stock photo testimonials im guessing they aren't actually operating

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#119

Post by n9com »

Glad to see more people working in this space. Hopefully you will be able to treat food allergies in a similar way, e.g. working up the milk ladder with a set course of pills.

My son was born with multiple food allergies, and whilst he has outgrown some, the current approach here is 'wait and hope they grow out of it' or 'try introducing the allergens very gradually so that the immune system learns to not react to the allergen').

One suggestion - state what allergies you can currently treat above the fold. I shouldn't need to scroll down to learn it is only for pollen, pet, and dust allergies. Best of luck!

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#120

Post by claytongulick »

whymauri wrote: post #41
ahstilde wrote: post #9

Earlier quoted context omitted.

Thank you for the feedback! On total cost: We charge $99/mo. It's hard to give a total cost without knowing more about each person's specific allergy triggers and how well immunotherapy takes for them. Generally, we expect patients to be with us for up 5 years. On how long treatment lasts: I spoke to this in the total cost section, but it's hard to make a blanket statement. On our at-home allergy test: We use a CLIA-…

How effective is this against eczema? Without proper insurance, this is a better deal than medications like Dupixent, right?

As someone who's battled this my whole life, and gone down a crazy number of rabbit holes on it, my personal recommendation to you is to try elimination diet.

Especially milk and milk products.

If you decide to try this, don't do it halfway. Read the ingredients of everything you eat. Don't eat at restaurants. Stick with it for three months.

I went from having difficulty walking, and being unable to use my hands due to severe dishydrotic eczema, to being completely 100% healed.

This was after I was diagnosed with shingles, given a ton of very harmful steroids and steroid creams, told by multiple doctors and dermatologists that it was an incurable autoimmune condition that I'd be living with forever.

I was also told explicitly by one dermatologist that it was impossible that my problems were caused by a food allergy, that any results I was seeing were coincidence.

It turned out, I'm allergic to milk protein.

If you're battling this as well, it might be worth your time to look into elimination diets.

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