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Early clinical trial shows anti-depressant prevents hospitalization from Covid

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Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid

#111

Post by spion »

JoshTko wrote: post #110
spion wrote: post #74

Earlier quoted context omitted.

Its also been shown not to have an effect in at least one RCT, but the problem is social media skews against spreading that information (its kind of a downer so it won't get shared so much) https://www.medrxiv.org/content/10.1101/2020.11.16.20232397v... (Yes, the RCT uses cholecalciferol instead of calcifediol, so the reason why the intervention did not work may be that its a bit late. Yes, the Spanish trial had extr…

So even just looking at these two studies, and the relatively safety and low cost of Vitamin D, why wouldn't you take it?

I would totally take it, but I wouldn't be very surprised if I still got a severe disease.

My point is that its important for people to have an accurate picture of what is the probability of it working, to have a good "feel" of what the likelihood of a good outcome is. Unfortunately social media is providing a skewed picture.

I'm not sure what mechanism would ensure that people get an accurate picture.

Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid

#112

Post by loceng »

PragmaticPulp wrote: post #4

To be clear, this isn't saying that any anti-depressant is effective for COVID. It appears to be a unique side-effect of Fluvoxamine. There are several existing drugs which have been found to have modulatory effects on early COVID infections. The key word here is "early", as most of them only have a significant impact before the infection gets out of control. Keep in mind that Hydroxychloroquine is one of the existin…

It makes me wonder - or seems to insinuate to - that Fluvoxamine may directly impact the immune system. The only other alternative is that some molecular structure of Fluvoxamine kills off the virus?

Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid

#113

Post by ketamine__ »

RobinL wrote: post #30
ericsoderstrom wrote: post #6

Earlier quoted context omitted.

With so many studies being done on covid (by basically every lab in the world capable of doing so), the self selection biases are especially strong. That is, every study that confirms some statistically significant effect (often with a small sample size) will be published, and all of the corresponding studies which confirm the null hypothesis are buried. So you get a flood of seemingly compelling early evidence for c…

Indeed. Presumably if it is effective, you could study people who are using Fluvoxamine for its anti-depressive properties, and you'd find that (other things equal, using something like propensity score matching), they have less serious cases of COVID.

I believe that is exactly how it was discovered as a potential treatment for Covid-19.

Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid

#114

Post by 67868018 »

mrandish wrote: post #46

This presentation from the Covid-19 Early Treatment Fund (a non-profit funding over a dozen trials) summarizes the data so far on Fluvoxamine. https://docs.google.com/presentation/d/1u7resy2bGA1_HIgj6Nc7... Executive Director Steve Kirsch wrote this post on the most promising early treatments and CETF feels Ivermectin and Fluvoximine are the two most promising which they are currently funding studies on. He's continu…

Ivermectin? The animal dewormer? Did COVID suddenly grow glutamate-gated chloride channels?

Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid

#115

Post by nikolay »

67868018 wrote: post #114
mrandish wrote: post #46

This presentation from the Covid-19 Early Treatment Fund (a non-profit funding over a dozen trials) summarizes the data so far on Fluvoxamine. https://docs.google.com/presentation/d/1u7resy2bGA1_HIgj6Nc7... Executive Director Steve Kirsch wrote this post on the most promising early treatments and CETF feels Ivermectin and Fluvoximine are the two most promising which they are currently funding studies on. He's continu…

Ivermectin? The animal dewormer? Did COVID suddenly grow glutamate-gated chloride channels?

Ivermectin has been known even before COVID-19 for having antiviral properties. And it's not an animal dewormer - it's been recognized as essential medicine for humans by the WHO and there's even a Nobel Prize for Medicine awarded for its application in eradicating parasites in humans. During the last 30 years, nearly 4 billion doses of it have been applied to humans.

Re: Early clinical trial shows anti-depressant prevents hospitalization from Covid

#116

Post by NationalPark »

LatteLazy wrote: post #64
NationalPark wrote: post #63

Earlier quoted context omitted.

Is there something specific that's wrong with their math?

They're lacking sufficient data to draw any real conclusions. Trend spotting like this requires very large data sets. It would be more interesting to look at (say) NHS data. That's the quick way to avoid this sort of guessing...

They describe their significance calculation.
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