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Biomarker of Alzheimer's found to be regulated by sleep cycles

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Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#111

Post by wpietri »

noja wrote: post #68
wpietri wrote: post #60

Earlier quoted context omitted.

I suspect the same will be true about artificial light. Our sleep cycles changed dramatically with the introduction of electric light. A few years back I built an automated lighting system [1] for my apartment that was basically a scaled-up version of a light-based alarm clock [2]. I got the expected benefit, getting up more easily in the morning. But it turned out the bigger benefit was going to sleep at a more regu…

I think Hue bulbs can do that out of the box.

They mostly can now, 6 years later. Although they still don't do two things I really like: 1) long, slow changes in light (my lights dim from 7 to 10 pm, but I think the app is limited to 1 hour), 2) color temperature shifts as part of that (my lights go from very warm at "dawn" to very cool at noon and back to very warm at "dusk".

Mine is also more opinionated; I can turn on the lights manually, but they'll go back in sync to the schedule after a bit. Whereas with the Hue app, if I change the lighting during an automatic cycle, it stops the automation until the next trigger point.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#112

Post by hertzrat »

zamfi wrote: post #97
sradman wrote: post #32

From the paper Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis [1]: > Regulation of glial activation and neuroinflammation are critical factors in the pathogenesis of Alzheimer’s disease (AD). YKL-40, a primarily astrocytic protein encoded by the gene Chi3l1, is a widely studied cerebrospinal fluid biomarker that increases with aging an…

> We further observed that expression of Chi3l1 is regulated by the circadian clock, as deletion of the core clock proteins BMAL1 or CLOCK/NPAS2 strongly suppresses basal Chi3l1 expression, whereas deletion of the negative clock regulators PER1/PER2 increased Chi3l1 expression. Basal Chi3l1 mRNA was nonrhythmic because of a long mRNA half-life in astrocytes. However, inflammatory induction of Chi3l1 was gated by the…

In this situation, what does disrupted circadian cycle refer to? Somebody who cannot sleep when they are tired and needs a lot of coffee in the morning? Or somebody who gets woken up a lot?

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#113

Post by wpietri »

airstrike wrote: post #96
noja wrote: post #68

Earlier quoted context omitted.

I think Hue bulbs can do that out of the box.

Indeed, and after setting up the auto wake up / sleep cycle, I had to turn it off because it was leading me to want to fall asleep at night when I still had a ton of work to get through As great as it would be to keep a more natural "lighting" cycle around the house, the truth is my modern obligations won't allow for that, so I have the lights on at full blast until midnight quite frequently I look forward to my reti…

I think it's worth asking how much more time spent equals more productivity. For me, that's only true for very short periods. I find I'm way more productive for the long haul if I'm getting plenty of sleep.

The thing that convinced me to try was this presentation from game developers on the limits of crunch time: https://lostgarden.home.blog/2008/09/28/rules-of-productivit...

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#114

Post by [deleted] »

oarabbus_ wrote: post #84

What does this mean for people with severe Delayed Phase Sleep Syndrome (DSPS)? I do not feel the need for sleep until usually about 2am, and I find it exceedingly difficult to wake up before 10am. And yes, it's made it extremely difficult to live a "normal" life like your typical person who can wake up at 7am without issue. It's been a problem with relationships, poor performance in school, issues in promotions and…

[deleted]

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#116

Post by [deleted] »

eecks wrote: post #105
oarabbus_ wrote: post #84

What does this mean for people with severe Delayed Phase Sleep Syndrome (DSPS)? I do not feel the need for sleep until usually about 2am, and I find it exceedingly difficult to wake up before 10am. And yes, it's made it extremely difficult to live a "normal" life like your typical person who can wake up at 7am without issue. It's been a problem with relationships, poor performance in school, issues in promotions and…

I wasn't diagnosed with this but I had the symptoms and the consequences you mentioned. It took a long time to fix. Here's some things I tried. Some may have helped or none may have helped. * I bought blackout blinds and use a sleeping mask (sometimes earplugs) * I bought a bright light ( https://www.amazon.co.uk/gp/product/B07FFJYMVS ) and a smart plug. 15 mins before I wanted to wake up I would have a timer turn on…

[deleted]

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#117

Post by madrox »

oarabbus_ wrote: post #84

What does this mean for people with severe Delayed Phase Sleep Syndrome (DSPS)? I do not feel the need for sleep until usually about 2am, and I find it exceedingly difficult to wake up before 10am. And yes, it's made it extremely difficult to live a "normal" life like your typical person who can wake up at 7am without issue. It's been a problem with relationships, poor performance in school, issues in promotions and…

There's no literature I'm aware of studying links between DSPD and Alzheimer's. However, DSPD is characterized as delayed sleep...not less sleep. As long as you're getting sufficient sleep and feel rested when you do sleep, I don't think it matters when you do it as it relates to this issue.

As someone who's dealt with DSPD in his 20s, I'll refrain from advice. I got no end of people telling me to exercise more, drink less caffeine, or any number of things like I hadn't desperately tried everything. My personal experience was that it naturally got easier in my late 30s, but the less I fought it and the more I worked around it the better I felt. If you are looking for help, I encourage you to check out the DSPD subreddit: https://www.reddit.com/r/DSPD/

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#118

Post by hertzrat »

eecks wrote: post #105
oarabbus_ wrote: post #84

What does this mean for people with severe Delayed Phase Sleep Syndrome (DSPS)? I do not feel the need for sleep until usually about 2am, and I find it exceedingly difficult to wake up before 10am. And yes, it's made it extremely difficult to live a "normal" life like your typical person who can wake up at 7am without issue. It's been a problem with relationships, poor performance in school, issues in promotions and…

I wasn't diagnosed with this but I had the symptoms and the consequences you mentioned. It took a long time to fix. Here's some things I tried. Some may have helped or none may have helped. * I bought blackout blinds and use a sleeping mask (sometimes earplugs) * I bought a bright light ( https://www.amazon.co.uk/gp/product/B07FFJYMVS ) and a smart plug. 15 mins before I wanted to wake up I would have a timer turn on…

Reminds me of wozniaks advice: https://supermemo.guru/wiki/Curing_DSPS_and_insomnia

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#119

Post by hertzrat »

LinuxBender wrote: post #67
bluedevil2k wrote: post #23

I'm curious if sleep aids, whether it's OTC like melatonin or Rx like trazodone and Ambien, can help this situation. Is it just the sleep that's beneficial or is it "natural" sleep (that term doesn't mean anything, but you get the point of it)? In other words, should people who have difficulty sleeping look to aids as a way of staving off dementia later in life.

Melatonin is a hormone that can assist you with falling asleep, but it has no capability to keep you asleep or allow you to reach the 4 stages of deep sleep. Ambien is worse, in that it can make you feel like you are going to sleep, but you will not get into the deep states of sleep required for the brain to detoxify itself. The same is true for weed. Some folks use weed to help themselves sleep, but they are actuall…

I was under the impression that melatonin regulates your sleep wake cycle, and so you take it to do a reset, not to just get to sleep one night

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#120

Post by woeirua »

You should take these findings with a big grain of salt. Remember we don't yet even have a causal model of Alzheimer's and dementia. Amyloid plaques are strongly associated with Alzheimer's but it's not clear if they're the actual cause or if they're just a residual indicator that something else has already gone wrong in the brain. As a counterpoint to the amyloid hypothesis, we also see amyloid build ups in patients suffering from sleep apnea, and yet they don't show the hallmark signs of dementia or Alzheimers [1].

[1] https://www.sciencedaily.com/releases/2020/09/200928103416.h...

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