111–120 of 266 posts
But we also have dozens of RCTs showing that vitamin D supplementation suppresses respiratory infections!
Folks always act like we just take this study in isolation. That’s not how it should work. The totality of the evidence is quite strong for vitamin D versus C19.
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Show notes are here. https://www.foundmyfitness.com/episodes/jre-1474
2 interesting references to vitamin D studies: 00:29:32 - In the Philippines, every standard deviation increase in serum vitamin D was associated with an 8 times more likely chance to have a mild rather than severe COVID-19 outcome and a 20 times more likely chance to have a mild rather than critical outcome. 00:30:37 - In Indonesia, 98.9% of patients with vitamin D deficiency died, 88% of patients with vitamin D ins…
Alipio, Mark, Vitamin D Supplementation Could Possibly Improve Clinical Outcomes of Patients Infected with Coronavirus-2019 (COVID-19) (April 9, 2020). Available at SSRN: https://ssrn.com/abstract=3571484 or http://dx.doi.org/10.2139/ssrn.3571484
Raharusun, Prabowo and Priambada, Sadiah and Budiarti, Cahni and Agung, Erdie and Budi, Cipta, Patterns of COVID-19 Mortality and Vitamin D: An Indonesian Study (April 26, 2020). Available at SSRN: https://ssrn.com/abstract=3585561 or http://dx.doi.org/10.2139/ssrn.3585561
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I've seen two theories floated: 1. Vitamin D as a side effect of sun exposure is not itself the important indicator. Instead, some other biological response increases immune response simultaneously. Hence, D supplementation is itself copying the wrong response. 2. Vitamin D deficiency is caused by illness, hence it actually doesn't affect mortality and the relationship is not casual.
My money is on 1. Vitamin D deficiency is caused by lack of sunlight. I'm skeptical of doctors telling me to avoid the sun and take a pill instead.
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This is a misnomer according to a recent guest on the Joe Rogan podcast. Granted that might not be the best source, I reflected on that and the chemistry makes sense. Vitamins primarily will leach out via osmosis. Osmosis works by gradients. This probably means an exponential decay of absorption relative to concentration and as you consume more, your body will waste progressively more and uptake will be less efficien…
Dr Rhonda Patrick was the guest if anyone is interested. Worth watching with paper and pen (or digital equivalent).
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However, taking 3 vitamins is almost entirely harmless.
Many are toxic (vitamin D included) in unsuitable amounts, that’s probably too strong of a statement.
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While toxic amounts of basically anything are bad, introducing random facts that have no bearing on what is discussed can mislead some readers into thinking you're making a point related to the topic at hand. While it may be unintentional, this is misleading and therefore not helpful.
Look at the context. I was responding to the implication that taking 3 vitamins is categorically safe. It is not.
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You are right and it is no secret: - 40% of US Americans are B12 deficient https://www.livekindly.co/b12-deficiency-genetic-makeup/#:~:... . - 42% are Vitamin D deficient: https://www.cantonmercy.org/healthchat/42-percent-of-america... . - up to 50% are Magnesium deficient: https://www.sciencedaily.com/releases/2018/02/180226122548.h... - 10 - 20% of women are iron deficient: https://www.aafp.org/afp/2007/0301/p671.h…
I've always wondered about this deficiency thing. How is it defined, and does it make any sense to claim that such a large part of the population is deficient? Shouldn't that be considered "normal" (excluding the truly pathological cases), as opposed to "above-average"?
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Vitamin overdoses can be serious in the worst cases. https://en.wikipedia.org/wiki/Hypervitaminosis_A https://en.wikipedia.org/wiki/Hypervitaminosis_D
Water overdoses can be serious in the worst cases, even fatal. https://en.wikipedia.org/wiki/Hyperhidrosis
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However, taking 3 vitamins is almost entirely harmless.
Many are toxic (vitamin D included) in unsuitable amounts, that’s probably too strong of a statement.
N=43 (17 given vitamins vs 26 not) Highlights: "Significantly fewer DMB patients than controls required initiation of oxygen therapy subsequently throughout their hospitalization (17.6% vs 61.5%, P=0.006)." "DMB combination in older COVID-19 patients was associated with a significant reduction in proportion of patients with clinical deterioration requiring oxygen support and/or intensive care support. This study supp…
Despite my somewhat limited knowledge in biology, my intuition was telling me that the number of patients seems way too small to come to definitive conclusions. Mind you, if Vitamin-D, magnesium and B12 play a role, that's good news for me: I've been very strict about those 3 in the past 2 years(and coincidentally loaded up my magnesium stash yesterday).