Those all appear to either emulate other consoles, or come with games built-in, though. This seems to be closer to the MakeCode consoles discussed elsewhere in these comments, since it sounds like it will allow you to make your own games for it (although it's not clear yet how easy that will be).
In that respect, it seems fairly unique to me, if only because it is beautifully designed and polished. It seems like the other options for making your own handheld games are either a bit clunky (eg Adafruit's PyGamers) or require quite a lot of know-how and effort (eg Gameboy or DS homebrew).
I hope that this will result in a bunch of new high-quality indie games. It seems that people are unlikely to invest a lot of effort in making spectacular games for the PyGamer, because the audience is small... Nintendo-handheld homebrew has the potential for a larger audience, but requires so much work that I imagine a lot of potential creators are dissuaded.
I'm on the lookout for a shiny indie-friendly portable that's easy to develop for, because I think that could lead to some exciting new things. Maybe this is it.