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How expensive do prescription drugs need to be to fund research?

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Re: How expensive do prescription drugs need to be to fund research?

#111

Earlier quoted context omitted.

Should the cost of CPUs be separate from the cost of CPU research? I understand it seems distasteful to place a cost on health and life, but isn't that just a reality? Everything has a cost. As long as the cost of drugs were reasonable , we wouldn't need to have these conversations.

> Should the cost of CPUs be separate from the cost of CPU research? Maybe not now when researching CPUs is fairly easy. But a century in the future? When faster CPUs will be very hard to invent but essential to human survival? Maybe. Business is great at researching processes of manufacturing. Not so good when it comes to researching actually new stuff. > As long as the cost of drugs were reasonable, we wouldn't nee…

> When faster CPUs will be very hard to invent but essential to human survival? Maybe.

I'd say we're already at the point that they are essential to our survival, at least for societies as they currently exist. CPUs are also hard to invent, and hard to progress already, requiring hundreds of millions of dollars for each new iteration.

> Business is great at researching processes of manufacturing. Not so good when it comes to researching actually new stuff.

I don't believe it. Most of the things we currently use were invented by businesses, or by someone who then started a business to sell it.

> But they must become unreasonable at some point if they cost as much as the incentive for research for companies.

Again, you're assuming the conclusion. Maybe this is the case in some circumstances, but it's a assuming a lot to claim this is the case for all companies and all drugs.

And if the cost is really this high, then incentivizing more creative approaches to treatment might just be better anyway. It shows a lack of imagination if we can only use a hammer when faced with a health problem.

Re: How expensive do prescription drugs need to be to fund research?

#112
post #44
post #16

Patent expirations don't factor into this article very much, but there's this: The simple explanation for excessive drug prices is monopoly pricing. Through patent protection and FDA marketing exclusivity, the U.S. government grants pharmaceutical companies a monopoly on brand-name drugs. But monopolies are a recipe for excessive prices. A company will raise prices until its profits start to drop. That monopoly is ve…

Indeed. Companies have a limited time to recoup costs. Once the patent runs out, that $10,000 drug turns into a $500 drug. Forever. That benefit can't be ignored.

There are many ways to extend the patent or the effect of the patent: https://www.upcounsel.com/how-long-does-a-drug-patent-last

Re: How expensive do prescription drugs need to be to fund research?

#114
post #112
post #44

Earlier quoted context omitted.

Indeed. Companies have a limited time to recoup costs. Once the patent runs out, that $10,000 drug turns into a $500 drug. Forever. That benefit can't be ignored.

There are many ways to extend the patent or the effect of the patent: https://www.upcounsel.com/how-long-does-a-drug-patent-last

There are and some of them are an abuse of the system. However, most drugs pretty quietly go generic.

A good example is Lipitor. For Pfizer it brought in over $11B per year in revenue. Cost was around $150 per month. You can now get a month’s supply for $5.94 according to GoodRx. That’s a 96% reduction in the cost.

Re: How expensive do prescription drugs need to be to fund research?

#115

Earlier quoted context omitted.

As others have said, you cant ignore the purchase price of the research, and the buyer has that because they sell high priced drugs ...that said, it makes a good point about how the incentives work. If the govt did Xprize-like rewards for medical goals, it would work similarly: you stop paying for failed research and only pay for success, just like the examples you cite. All told, I think too many electrons are spill…

I don’t quite understand your point about govt-funded Xprize-like rewards—who is paying for failed research under such a regime? Is a govt-provided IP monopoly not itself an “Xprize-like reward?”

The concept that has been upheld for the current system in the past is: Companies do R&D, some fails, and some succeeds, and the profits from the successes pay for both the failures and successes.

The poster I was replying to points out that this concept isn't actually what is happening (at least, anymore, for some areas) - instead, smaller companies do R&D - some fail, and the investment is lost; some succeed, and the profit from being BOUGHT rewards the investment. The reward for success is great enough that some investors will gamble on these small companies (while the big companies investors are investing with lower risk, lower rewards).

I pointed out that this is very similar to the XPrize - private investment was done in many companies, but only one (ish) would win. (This is actually a bad analogy, since the XPrize was much more about status - the prize wasn't large enough to truly be significant to a company that could claim it). My (unspoken) point was that the govt could stipulate controls on the resulting product - companies could research with greater confidence of what payout they'd get (on success, of course), but the incentive for price gouging is removed.

The difference between today's IP-monopoly and the XPrize is that the prize was a known amount, and in the part I didn't state, minimal profit would be had past that, compared to today's "you get as much as you can gouge, for as long as you can abuse rent-seeking".

Really I just did a terrible job of explaining my point.

Re: How expensive do prescription drugs need to be to fund research?

#116

Earlier quoted context omitted.

But if the product you're selling in your store was made using charity? Or gifted you by the government? then high prices couldn't be justified by R&D costs.

True, but remember that you're not just paying for the research cost of Drug_X when you price Drug_X. You're also paying for all the research that failed, that didn't produce a useful drug. If you spend 100 million researching 100 drugs, and one of them produces something you can sell, you don't need to make back 1 million when selling that drug. You need to make back 100 million, plus a profit.

This is patently false. Without regulation, all goods are priced by what the market will bear. It might be true that if successful drug doesn't make enough to cover the cost of failed drugs the company will go out of business but that has nothing to do with pricing.

The problem is that without competition drug companies can keep raising the price as long as enough people will buy it at the new price so that they make more money than all of the people buying it at the old price. That is why really old drugs that have been around for a long time have their prices increase. Not because there was some new research but because the lack of alternatives means they can just do it.

Re: How expensive do prescription drugs need to be to fund research?

#117

However expensive it is, it should cost the same in all markets globally, whether it's being purchased by a patient in cash, by an NGO, by a state Healthcare system, or by an insurance company. I'm tired of paying a five hundred percent markup to subsidize markets thousands of miles away.

You're not subsidizing the markets far away. Price discrimination isn't subsidizing. The supplier is just able to extract the maximum price from each market.

> The supplier is just able to extract the maximum price from each market.

And they are able to do that because laws have been passed in their favor to legally bar other people from simply importing the exact same products from other markets where they are sold at much lower prices.

Price discrimination isn't subsidizing, per se, but the scope for price discrimination is very limited in the absence of government support due to arbitrage. Governments interfering in the market to enable price discrimination is very much a form of subsidy, even if the money isn't passing through the government on its way to the supplier.

Re: How expensive do prescription drugs need to be to fund research?

#118
post #36

Earlier quoted context omitted.

Yeah, I'm not a pharmaceutical, but I have a side hustle of sorts. When I give something away, I'm only allowed to deduct the marginal cost.

But marginal cost for whom? The entity manufacturing the drug, the entity that holds the inventory, the entity that owns the IP, or the entity that the pharmaceutical rep works for? Any sufficiently large corporation is more likely than not to be an amalgamation of interconnected subsidiaries, for a wide variety of purposes. Once you're at that stage, there's a lot of room to get creative with how you structure intra…

Good points, they can just shuffle the money from one balance sheet to another, but then get to deduct the whole thing anyway.

Re: How expensive do prescription drugs need to be to fund research?

#119

Earlier quoted context omitted.

> Should the cost of CPUs be separate from the cost of CPU research? Maybe not now when researching CPUs is fairly easy. But a century in the future? When faster CPUs will be very hard to invent but essential to human survival? Maybe. Business is great at researching processes of manufacturing. Not so good when it comes to researching actually new stuff. > As long as the cost of drugs were reasonable, we wouldn't nee…

> When faster CPUs will be very hard to invent but essential to human survival? Maybe. I'd say we're already at the point that they are essential to our survival, at least for societies as they currently exist. CPUs are also hard to invent, and hard to progress already, requiring hundreds of millions of dollars for each new iteration. > Business is great at researching processes of manufacturing. Not so good when it…

> Most of the things we currently use were invented by businesses, or by someone who then started a business to sell it.

Yes. I don't say business is useless when it comes to research. Business is great at researching how to tune the production process so that the thing they went to produce is affordable for as many people as possible.

Every invention goes through business to reach you. But it usually starts at the university on in military research.

> Again, you're assuming the conclusion.

I don't think I do.

1. Companies fund research with selling drugs they invent.

2. Inventing drugs gets more expensive.

1 & 2 => drugs get more expensive.

Re: How expensive do prescription drugs need to be to fund research?

#120

Earlier quoted context omitted.

You're not subsidizing the markets far away. Price discrimination isn't subsidizing. The supplier is just able to extract the maximum price from each market.

> The supplier is just able to extract the maximum price from each market. And they are able to do that because laws have been passed in their favor to legally bar other people from simply importing the exact same products from other markets where they are sold at much lower prices. Price discrimination isn't subsidizing, per se, but the scope for price discrimination is very limited in the absence of government supp…

I think I agree with this entirely.
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