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CRISPR machines that can wipe out entire species

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111–120 of 122 posts

Re: CRISPR machines that can wipe out entire species

#111

Earlier quoted context omitted.

Sounds like youre suggesting creating a mosquito malaria vaccine

Not entirely - I'm suggesting still altering the species but not with extinction as a consequence.

I agree, a vaccine would be one way to accomplish that

Re: CRISPR machines that can wipe out entire species

#112

It's horrible that people are dying because of malaria. I'm a bit divided on this approach though, I don't know enough about the topic at hand to suggest a different approach, but let me try. Would it be feasible to suggest using CRISP to create another adaptation to the gene, one that preserves the mosquitoes but makes them unable to transfer the disease to humans? Eliminating a species because we don't like it remi…

Some interesting prior discussion in this older comment thread: https://news.ycombinator.com/item?id=15929339

My understanding is that out of 3,500 mosquito species, only about 40 transmit malaria. Most of what I've read from experts implies they're not sure that mosquitoes play any biologically important role at all, and it seems like if there is some role (other than killing humans), the other 99% of non-eradicated mosquito species could fill in that gap.

In my (decidedly non-expert) opinion, that's good enough to start making moves towards eradicating the mosquito-causing species.

Re: CRISPR machines that can wipe out entire species

#113

What technical limitations allow us to genetically target mosquitos with this but not the malaria parasite itself?

This is a good question. I don't have a full answer.

The proposed gene drive causes male mosquitoes to produce sperm that, when it fertilizes egg cells, will lead to only make offspring. After several generations of this spreading, eventually all offspring will be male, and that will be the last generation.

The gene drive does this by attacking the genes in the mosquito sex determination system called doublesex. I guess, no-one has discovered a similar vulnerable mechanism in the malaria plasmodium sex determination genes. The malaria plasmodium is a single-celled organism, and it goes through both asexual and sexual reproductive phases in its life cycle. But it does go through the sexual phase, too.

https://en.wikipedia.org/wiki/Doublesex

Re: CRISPR machines that can wipe out entire species

#114
post #85
post #49

Earlier quoted context omitted.

Pretty much all projects of large-scale human ecological interventions ended up with some unexpected side-effect. It's extremely hard to take into account all the variables and often you fix one issue, but create 10 new ones. Just think of using myxomatosis to control rabbit population, or introduction of cane toads in Australia in attempt to control sugarcane pests.

Erradication of smallpox?

Well, it's a bit different with viruses as they're not directly part of the food chain for complex organisms - unlike mosquitos that are important food source to many insects, fish and birds. For instance for some fish and their fry the mosquito larvae are the primary food source, so if you destroy the complete population of mosquitos you might also severely affect some fish species. Some spiders and birds will also be left hungry. That can then affect other ecological niches up the food chain, perhaps even cause a collapse of the whole biotop system.

Re: CRISPR machines that can wipe out entire species

#115

ITT: people who live in countries that aren’t ravaged by malaria share their vague feelings of doubt about whether or not getting rid of mosquitos is a good idea

Plus we're already losing at least 200 species (of plant, insect and animal) every year. Might as well save half a million human lives while we're at it..

Re: CRISPR machines that can wipe out entire species

#116
I remember having a conversation with a friend a couple years ago, about a hypothetical scenario where a more intelligent species would someday threaten human existence. We'd then point to mosquitoes and say, look how we hate these little guys and they are still everywhere.

Well, that was that.

Re: CRISPR machines that can wipe out entire species

#117
post #64

Earlier quoted context omitted.

There is no biological basis for the word race.

I find this meme annoying because it so often misses the point (as I'd argue it does in this particular discussion). Yes, races are largely a social concept. However, once society has defined races based on whatever phenotypes that are in fashion at the time, it turns out that yes, there is a biological and genetic basis for those phenotypes . It's conceivable that this biological basis could be targeted by some gene…

I understand what you are saying and there is definitely a difference in phenotype but from what I've read the it's not possible to make a distinction because the interrace variance is smaller than the intrarace variance. It might be hard targeting a specific race with biological tools when it's hard to specify race biologically. But yeah there is difference in people appearance depending on location of origin.

Re: CRISPR machines that can wipe out entire species

#118
post #99

Earlier quoted context omitted.

I'm really struggling to understand your first sentence. Are you saying people generally aren't racist outside the US? Because my experience has been very, very different (and that's as a white male)

I think he references the fact that in the US you get official forms from the gov that asks (as far as I remember): Race: - white - black - hispanic - other Like when you get your driver license or open a bank account. Coming from Europe I was surprised by such a question. Racial issues run very deep in the US.

This is what I was referring to.

Re: CRISPR machines that can wipe out entire species

#119
post #99

Earlier quoted context omitted.

I think he references the fact that in the US you get official forms from the gov that asks (as far as I remember): Race: - white - black - hispanic - other Like when you get your driver license or open a bank account. Coming from Europe I was surprised by such a question. Racial issues run very deep in the US.

This is what I was referring to.

Ah, I understand now. As some anecdata: here in Singapore (a country I think is renowned for it's multiculturalism, but correct me if I'm wrong), practically every important form, from opening a bank account to renting a condo to filing taxes with the government, requires me to select my race from a list of "Chinese", "Malay", "Indian" or "Other". In Thailand, it's normal for people to specify their race and religion on their resume.

Re: CRISPR machines that can wipe out entire species

#120
post #58
post #11

Earlier quoted context omitted.

Can't we at least have backup plan to reintroduce?

Reintroduce malaria?

Moscitos, but now that I think about it.. If a whole population shows massive allergic reactions because the imuno system fights on after the threat is gone..
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