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Ibuprofen alters human testicular physiology

pnas.org

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Re: Ibuprofen alters human testicular physiology

#111

Post by chrsstrm »

TheSpiceIsLife wrote: post #35
fencepost wrote: post #13

Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?

Infrequent, occasional use of opiates, for two or three days shouldn't be a problem. You do have to make a bit of an effort to get addicted to opiates, insofar as taking a pill a day for a couple of weeks constitutes effort .

I had seemed to think that 10 days was the threshold but it turns out to be half that - http://www.newsweek.com/cdc-opiate-addiction-572498

Re: Ibuprofen alters human testicular physiology

#112

Post by ansgri »

felipelemos wrote: post #48
fencepost wrote: post #13

Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?

I hope that dipyrone be safe.

May cause agranulocytosis, according to wiki. https://en.wikipedia.org/wiki/Metamizole

Re: Ibuprofen alters human testicular physiology

#113

Post by pasquinelli »

rhexs wrote: post #85
ChristianGeek wrote: post #55

Earlier quoted context omitted.

It’s worth noting that a legal version, extracted from Hemp (a form of Cannabis that has no psychoactive properties), is available via mail order anywhere in the U.S.

I looked into the hemp based extract a while back and the conclusion I drew was that it was up for debate whether or not it was legal. Proponents cited a bunch of laws regarding industrial hemp while the DEA seemed to have another position entirely. Was this finally settled or is it still a bit gray?

i've heard of a cbd extract from hops, but i'm not sure whether it's true.

Re: Ibuprofen alters human testicular physiology

#114

Post by hesdeadjim »

wildmusings wrote: post #99
Alex3917 wrote: post #15

At 1200mg/d, I feel like destroying your reproductive system would be the least of your concerns.

I've had two doctors suggest taking over 2000mg a day like it was nothing. One of them was a fellow hiker on the Appalachian Trail and suggested it as a daily regimen for regular joint pain (common for long-distance hikers). The other suggested it for aiding recovery from mild frostnip. (In both cases, I ended up only taking it for a few days.) Unless you have stomach problems—NSAIDs are linked to ulcers—high doses o…

A nephrologist I went to a year or two ago explained to me that the danger of ibuprofen is total lifetime consumption. Once you approach 9lbs or so (surprisingly easy to hit if your habit is daily) your risk of kidney failure increases exponentially.

Re: Ibuprofen alters human testicular physiology

#115

Post by nikolay »

fencepost wrote: post #13

Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?

In Europe, there's Aspirin-C and Upsarin, basically, pure aspirin with vitamin C, which eliminates the stomach lining issues [0]! I have no idea why this is not offered in America. Maybe, because there's no way to make money from patents and stuff!

[0]: https://www.huffingtonpost.com/leo-galland-md/aspirin-and-vi...

Re: Ibuprofen alters human testicular physiology

#116

Post by [deleted] »

fencepost wrote: post #13

Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?

[deleted]

Re: Ibuprofen alters human testicular physiology

#117

Post by pkaye »

wildmusings wrote: post #99
Alex3917 wrote: post #15

At 1200mg/d, I feel like destroying your reproductive system would be the least of your concerns.

I've had two doctors suggest taking over 2000mg a day like it was nothing. One of them was a fellow hiker on the Appalachian Trail and suggested it as a daily regimen for regular joint pain (common for long-distance hikers). The other suggested it for aiding recovery from mild frostnip. (In both cases, I ended up only taking it for a few days.) Unless you have stomach problems—NSAIDs are linked to ulcers—high doses o…

My nephrologists all say NSAIDs on long term use have a risk for acute kidney failure. They say Tylenol is safe in long term as long as liver is otherwise healthy and you stay under daily dosage limit.

Re: Ibuprofen alters human testicular physiology

#118

Post by pkaye »

ardit33 wrote: post #23

If you hang around bodybuilding forums you will hear to avoid Ibuprofens as they hurt your ‘gains’ Perhaps bro-science was right in this case

What I've read is that NSAIDs in reducing inflamantion, it can slow down the mobilization of immune cells that help clean up damaged tissues and promote new tissues.

Re: Ibuprofen alters human testicular physiology

#119

Post by wildmusings »

hesdeadjim wrote: post #114
wildmusings wrote: post #99

Earlier quoted context omitted.

I've had two doctors suggest taking over 2000mg a day like it was nothing. One of them was a fellow hiker on the Appalachian Trail and suggested it as a daily regimen for regular joint pain (common for long-distance hikers). The other suggested it for aiding recovery from mild frostnip. (In both cases, I ended up only taking it for a few days.) Unless you have stomach problems—NSAIDs are linked to ulcers—high doses o…

A nephrologist I went to a year or two ago explained to me that the danger of ibuprofen is total lifetime consumption. Once you approach 9lbs or so (surprisingly easy to hit if your habit is daily) your risk of kidney failure increases exponentially.

Interesting. I guess that's consistent with those doctors' advice since in both cases it suggested for a limited period, a few months and a few days.

Re: Ibuprofen alters human testicular physiology

#120

Post by fragsworth »

mlloyd wrote: post #54

I've taken entirely too much Ibuprofen - I've had a lot of babies. Since the sample size of this study is 31 people, I say that my one case is significant and this study is bunk. That's why you can't rely on a study of 31 people.

It could have easily impacted your hormone production without destroying your ability to have babies.
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