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CRISPR eliminates HIV-1 infection in live animals

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Re: CRISPR eliminates HIV-1 infection in live animals

#111
post #97
post #32

Back in 2011, there was an announcement from MIT about a new approach to a broad-spectrum antiviral that appeared to work.[1] This goes way beyond an AIDS-specific cure. But it was at MIT Lincoln Labs, which doesn't usually do bio. So the researcher moved to Draper Labs, but didn't get much funding. Then that funding ran out. Now the guy behind this is trying to get funding on Indiegogo.[3] The problem seems to be th…

It's suspicious that in 6 year he hasn't received any substantial funding. Anyways here is a link for donations: https://riderinstitute.org/pages/donate-to-draco-antiviral-r...

his first target is HSV. HSV is a cash cow. innovators dilemma applied to pharma-cash

Re: CRISPR eliminates HIV-1 infection in live animals

#112
post #32

Back in 2011, there was an announcement from MIT about a new approach to a broad-spectrum antiviral that appeared to work.[1] This goes way beyond an AIDS-specific cure. But it was at MIT Lincoln Labs, which doesn't usually do bio. So the researcher moved to Draper Labs, but didn't get much funding. Then that funding ran out. Now the guy behind this is trying to get funding on Indiegogo.[3] The problem seems to be th…

If it actually worked or was promising, people would be throwing money at him.

Re: CRISPR eliminates HIV-1 infection in live animals

#113
post #15

Earlier quoted context omitted.

> Right now HIV infections are basically a minor nuisance, provided you're taking the appropriate medication Even with your caveat, the fact that more than 1 million people died from HIV in 2015 is probably a good signal to not use the term "minor nuisance". https://www.cdc.gov/hiv/basics/statistics.html

People who don't have access to truvada definitely aren't going to be getting cutting-edge gene therapy any time soon. And how many people died of type I diabetes in 2015?

That's another condition I'd probably not call a "minor nuicance".

Re: CRISPR eliminates HIV-1 infection in live animals

#114

Earlier quoted context omitted.

Are there other nations which have less demanding requirements, but still decent vetting? Why can't these kinds of ideas go there?

One factor is that by far the biggest profits are to be had in the US. Maybe you can get approved in Australia or Sweden, but that will pay negligible sums compared to getting into the US market.

Could try for market pressure - for example, that male birth control being developed in India we keep hearing about. I bet it'll get approved here faster than normal because of how desired it is.

Re: CRISPR eliminates HIV-1 infection in live animals

#115
post #81

Earlier quoted context omitted.

So, was he right?

Short answer: Yes. Longer answer: When I first read it, I didn't think that the limitation that he had proposed applied to the type of device that we were making. He was really criticizing a similar but-not-identical type of fusion concept, and I clung to the differences. However, as our work progressed, I saw that the basic concept applied, which is that the scattering which would occur in a plasma (or a beam) would…

That sounds dope though, I have no idea what kind of materials you guys worked with but I imagine the kinds that raise eyebrows from the local governments. How did you overcome that sort of stuff? Strict safety requirements, etc.

Re: CRISPR eliminates HIV-1 infection in live animals

#116

In 2013 a very highly-placed Goldman Sachs exec, a friend of a friend, told me his AMFAR contacts predicted a 'genetics-based cure' in a 3-4 years instead of the 10 years they publicly projected. The rationale was donations would stop if people knew how close they were to a cure.

Even if AIDS is defeated, there's always other medical maladies that affect people. MRSA, for one.

Re: CRISPR eliminates HIV-1 infection in live animals

#117

In 2013 a very highly-placed Goldman Sachs exec, a friend of a friend, told me his AMFAR contacts predicted a 'genetics-based cure' in a 3-4 years instead of the 10 years they publicly projected. The rationale was donations would stop if people knew how close they were to a cure.

Even if AIDS is defeated, there's always other medical maladies that affect people. MRSA, for one.

That's not really the attitude towards curing disease.

Re: CRISPR eliminates HIV-1 infection in live animals

#118

Earlier quoted context omitted.

Given billionaires running their own space programs it makes me wonder why there aren't more billionaires running biologic research companies. Between life extension and immunity to (or protection from) really pathological conditions it seems like their interests would be aligned with folks like this.

> billionaires running biologic research companies D. E. Shaw Research is exactly this. Haven't heard of others, though.

I still remember the surprise I felt when I idly Googled the author of some computational chemistry paper, only to find he was a billionaire :-)

Re: CRISPR eliminates HIV-1 infection in live animals

#119
post #32

Back in 2011, there was an announcement from MIT about a new approach to a broad-spectrum antiviral that appeared to work.[1] This goes way beyond an AIDS-specific cure. But it was at MIT Lincoln Labs, which doesn't usually do bio. So the researcher moved to Draper Labs, but didn't get much funding. Then that funding ran out. Now the guy behind this is trying to get funding on Indiegogo.[3] The problem seems to be th…

Given billionaires running their own space programs it makes me wonder why there aren't more billionaires running biologic research companies. Between life extension and immunity to (or protection from) really pathological conditions it seems like their interests would be aligned with folks like this.

Human Longevity INC San Diego, run by Craig Venter. http://www.humanlongevity.com/about/management-team/

Re: CRISPR eliminates HIV-1 infection in live animals

#120
post #91
post #75

Earlier quoted context omitted.

My scientist friends tell me China is paying well, making funding available, and has a lower go-to-market burden. Innovation appears to be literally moving to China as talent is being drained away from the US & Europe.

Just for biotech?

I'd count commodity electronics in there.
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