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Vibe coding my way to a healthy family: Introducing Gamow Labs

ddmckinnon.com

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Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#101

Post by utopiah »

hashmap wrote: post #95
331c8c71 wrote: post #63

The post is written almost as if there is no prior art on (germline) variant interpretation. In fact, it is an established niche field with multiple commercial vendors existing for years (and diagnostics for critically ill infants is the most well known use case - google Stephen Kingsmore or Rady's children hospital for one). I'd be surprised if the approach is really something novel at this point. It is definitely t…

> I'd be surprised if the approach is really something novel at this point. this is a very common reaction to people doing things with llms and i think the effects of it can be somewhat insidious. you constantly see people out there vibing their way to something that has already been discovered somewhere else, but they didn't know that and in many cases wouldn't have known how to find that thing even if they did. the…

Interesting I didn't think about it this way but it's indeed a kind of IKEA effect assuming that P-creative is H-creativity (as defined by Boden) which is totally aligned with incentives of using models.

They have to be useful, otherwise nobody comes back, and used, not just a starting point that can be bypassed after doing it a couple of time. Instead of pointing out to what exists, basically what a search engine does, it "helps" the user by building. It also gives an amazing sense of agency and power, you "do" get something that seems to come out of nothing, conveniently removing provenance and thus make the user feel quite good about the process.

This is especially poignant to me given this anecdote from a friend I shared just days ago https://news.ycombinator.com/item?id=48457842 showcasing how we wrote a Wacom driver, on his own, without being a developer, thanks to Claude, and how he even potentially helped others by sharing back what he "built" only for someone to suggest an already existing project https://news.ycombinator.com/item?id=48459366 .

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#102

Post by 331c8c71 »

dmckinno wrote: post #96
331c8c71 wrote: post #63

The post is written almost as if there is no prior art on (germline) variant interpretation. In fact, it is an established niche field with multiple commercial vendors existing for years (and diagnostics for critically ill infants is the most well known use case - google Stephen Kingsmore or Rady's children hospital for one). I'd be surprised if the approach is really something novel at this point. It is definitely t…

It's funny you mention Dr. Kingsmore and Rady. While I am truly grateful for him and the team for their contributions to neonatal genetics (and hosting me in San Diego for a few days to show me how I could help), Rady was actually the unnamed lab that failed to diagnosis my son. And this happens all the time. The WGS NICU diagnostic rate is only ~30%, depending on who you ask. Just because people have been working at…

Thanks for the reply. I have read your post but I haven't seen the preprint obviously and without knowing the details I remain skeptical.

> The WGS NICU diagnostic rate is only ~30%, depending on who you ask.

Agreed. It does not automatically mean, however, that it can be significantly improved with better variant interpetation or better analysis of the same wgs data in general sense.

> I'm planning on publishing evals and benchmarks in the next few weeks, but out-of-the-box systems actually don't do very well for a variety of reasons.

Happy to see it. I wish you all the luck and will be the first one praising your solution if I see convincing results.

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#104

Post by mixdup »

onion2k wrote: post #64
nkrisc wrote: post #36

Earlier quoted context omitted.

People born with Down syndrome deserve all the respect and dignity any other person does. I have two kids. If I could have chosen whether or not they would be born with Down syndrome I would choose would “without” every single time. If either of them were born with it I would love them the same but I would never choose it, if I had the choice to make.

The point the OP is making is that given the choice parents will always choose a 100% 'perfect' child who will live a happy and long life free from things that make it difficult. Until relatively recently this hasn't actually been a choice though - as much as you'd like that, you've not been about to tell much about the long term future of a foetus so you got what Mother Nature blessed you with. Increasingly though,…

>The question is where that ends. Terminating due to a susceptibility to aggressive cancer? Maybe. Due to lower intelligence? Perhaps. Lower physical strength? Probability of autism? Unsymmetrical facial features (e.g. 'ugliness')?

Why/how a pregnancy started (consensually or not for example) or the motivation behind making that choice (just don't want a kid, some genetic diagnosis, etc) are irrelevant. If abortion is bad, it shouldn't be done at all. If it's not bad the reasons behind it should not matter

Always breaks my brain when people argue abortions in case of rape or incest are OK but otherwise a woman should be forced to carry a pregnancy to term, as if it matters to the potential child in the end. Either you're killing a person or not. I'm pro-choice, so it's my opinion that you're not, but the wishy-washy middle ground position is untenable to me.

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#105

Post by utopiah »

utopiah wrote: post #101
hashmap wrote: post #95

Earlier quoted context omitted.

> I'd be surprised if the approach is really something novel at this point. this is a very common reaction to people doing things with llms and i think the effects of it can be somewhat insidious. you constantly see people out there vibing their way to something that has already been discovered somewhere else, but they didn't know that and in many cases wouldn't have known how to find that thing even if they did. the…

Interesting I didn't think about it this way but it's indeed a kind of IKEA effect assuming that P-creative is H-creativity (as defined by Boden) which is totally aligned with incentives of using models. They have to be useful, otherwise nobody comes back, and used, not just a starting point that can be bypassed after doing it a couple of time. Instead of pointing out to what exists, basically what a search engine do…

Related professional ramblings few days ago https://news.ycombinator.com/item?id=48353270 (TL;DR: more code isn't better, doesn't matter who or what wrote it)

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#106

Post by w0m »

darkwater wrote: post #76
myzek wrote: post #23

My first son will be born in 2 months and I must say, between stories like this and others that I learned in antenatal classes - I have never been more terrified in my life

You start worrying when they are in the womb... and never really stop worrying til you die.

I had no idea I would turn into a helicopter. it's kind of crazy how it rewires you.

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#107

Post by hombre_fatal »

adamtaylor_13 wrote: post #93
hombre_fatal wrote: post #83

Earlier quoted context omitted.

The sword being just deciding which embryos you will raise? It's very easy to demand or promote sacrifices you expect other people to make. But I don't find that to be very empathetic. I've already seen how society is when we shame and hand-wring about the personal decisions others make, and it's not one I want for my kids. At some point you need to be satisfied with your own decisions and then let other people make…

I reject the premise of "live and let live" whereby no one is allowed to suggest I live a better life nor am I allowed to suggest they improve theirs. I can be both satisfied with my decisions and still wish better for my neighbor; these are not mutually exclusive. I am not saying, don't choose between embryos. I'm saying, be careful because it's a slippery slope and not a slide you want to ride.

Let's set the standard at development and genetic disorders.

Eliminating Down syndrome and cystic fibrosis, for example, seems not only reasonable but a moral imperative.

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#108

Post by dmckinno »

331c8c71 wrote: post #102
dmckinno wrote: post #96

Earlier quoted context omitted.

It's funny you mention Dr. Kingsmore and Rady. While I am truly grateful for him and the team for their contributions to neonatal genetics (and hosting me in San Diego for a few days to show me how I could help), Rady was actually the unnamed lab that failed to diagnosis my son. And this happens all the time. The WGS NICU diagnostic rate is only ~30%, depending on who you ask. Just because people have been working at…

Thanks for the reply. I have read your post but I haven't seen the preprint obviously and without knowing the details I remain skeptical. > The WGS NICU diagnostic rate is only ~30%, depending on who you ask. Agreed. It does not automatically mean, however, that it can be significantly improved with better variant interpetation or better analysis of the same wgs data in general sense. > I'm planning on publishing eva…

> Agreed. It does not automatically mean, however, that it can be significantly improved with better variant interpetation or better analysis of the same wgs data in general sense.

I wouldn't say anything is automatic or taken for granted, but it is actually relatively common for more thorough reanalysis to uncover something that the first pass missed. I hinted at this in the post, but the reason that this doesn't happen today is human bandwidth.

A core part of my thesis is that that this highly specialized human bandwidth can be scaled with AI.

It may work. It may not work. But I would feel bad if I didn't give it a try.

> Happy to see it. I wish you all the luck and will be the first one praising your solution if I see convincing results.

Appreciate that! Hopefully, they will come.

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#109

Post by picofarad »

mixdup wrote: post #104
onion2k wrote: post #64

Earlier quoted context omitted.

The point the OP is making is that given the choice parents will always choose a 100% 'perfect' child who will live a happy and long life free from things that make it difficult. Until relatively recently this hasn't actually been a choice though - as much as you'd like that, you've not been about to tell much about the long term future of a foetus so you got what Mother Nature blessed you with. Increasingly though,…

>The question is where that ends. Terminating due to a susceptibility to aggressive cancer? Maybe. Due to lower intelligence? Perhaps. Lower physical strength? Probability of autism? Unsymmetrical facial features (e.g. 'ugliness')? Why/how a pregnancy started (consensually or not for example) or the motivation behind making that choice (just don't want a kid, some genetic diagnosis, etc) are irrelevant. If abortion i…

I am pro-choice, but really I'm hoping there is enough advancement in medicine to "fix" genetic issues and the sorts of things people would terminate after a positive test result.

If that is actually possible someday, legitimately, I am switching to pro-life.

With only rape/incest or mother's certain death as reasons for termination.

I realise this is a weird and nuanced take, but I was adopted and it was back when they forced the mother to keep the kid for 6 months before they'd place tbe kid. Puritanical nonsense?

Make it so accidental pregnancy is 0.0001% (a thousand times less likely than perfect condom and pill/IUD use;) and the above "can fix", and what reason would there be to terminate?

I am anti-death penalty too.

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#110

Post by darkwater »

w0m wrote: post #106
darkwater wrote: post #76

Earlier quoted context omitted.

You start worrying when they are in the womb... and never really stop worrying til you die.

I had no idea I would turn into a helicopter. it's kind of crazy how it rewires you.

Being an helicopter has a specific (and negative) meaning; caring and worrying for your kids seems just how many humans are wired.
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