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Nuclear receptor 4A1 linked to health effects of coffee: study

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Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#101

Post by panabee »

gausswho wrote: post #93
panabee wrote: post #48

Here are more fascinating facts about caffeine and cancer. Caffeine affects the immune system via at least two opposing mechanisms. Mechanism 1: A2A receptor antagonism (immunostimulatory) Tumors and damaged tissues release adenosine, which engages the A2A receptor on immune cells and signals them to stand down. Caffeine antagonizes (i.e., blocks) this receptor. Mechanism 2: Raising intracellular cAMP (immunosuppress…

Would it be tenable to link caffeine as just asking your body (and heart) to work more, trading cancer for heart disease?

Great question. The bar for proof in biomedicine is naturally high. I only shared facts because so much is unknown.

If you can find a lab exploring the question, maybe you can support them by helping to raise money for experiments.

As a fun intellectual exercise, dive into the topic and challenge yourself to think about what kind of experiments could shed more light on the subject.

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#102

Post by panabee »

lazyasciiart wrote: post #63
panabee wrote: post #48

Here are more fascinating facts about caffeine and cancer. Caffeine affects the immune system via at least two opposing mechanisms. Mechanism 1: A2A receptor antagonism (immunostimulatory) Tumors and damaged tissues release adenosine, which engages the A2A receptor on immune cells and signals them to stand down. Caffeine antagonizes (i.e., blocks) this receptor. Mechanism 2: Raising intracellular cAMP (immunosuppress…

Absolutely. I was recently diagnosed with MPN, an odd “you’re probably fine” blood cancer, looking to learn everything.

Will aim to ground the framework -- Cancer Mini-101 for Engineers -- in personal use cases. I hope it will be helpful for you.

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#103

Post by ehnto »

fullstop wrote: post #84
technothrasher wrote: post #5

"While caffeine is the major individual component of coffee, the study suggests that it may not be the primary driver of these health effects." All you haters that give me grief for drinking my daily cup of decaf can shut up now.

Hey, man, drink what you want. It doesn't change my life in any way, shape, or form. But I have to ask, have you seen the image describing where decaf coffee comes from? https://i.imgur.com/aDt06Lg.png I do find it amusing. But drink your decaf, brother, do what works for you.

I should hope you're not being serious! In case anyone thinks this is real, decaf is not made from the dirt. It's beans that have gone through one of a few different processes. Swiss water method is what I prefer due to the low chemical processing.

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#104

Post by afc »

jorvi wrote: post #47
Bridged7756 wrote: post #27

I love coffee. It's good for you, it smells and tastes so good. It wakes you up, and prevents sleepiness after meals. Its stimulant nature is a plus, but not necessarily the main thing.

Unfortunately the most flavorful methods (espresso, french press, moka) also raise your cholesterol. So sadly, no, coffee is not universally "good for you". Filtered coffee methods are though, as the filter absorbs the oils.

But filtered coffee is the most flavorful! No other method extracts the subtle nuances as well! P.s. I know it's subjective, just cringe on this claim of "the most flavorful" starting with espresso. :)

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#105

Post by esperent »

vikingerik wrote: post #92
esperent wrote: post #55

Earlier quoted context omitted.

> Several big cups of decaf can approach the caffeine content of one regular cup Do you have a source for this? Because it doesn't sound right to me. And also, I live in a coffee producing company, work adjacent to the coffee industry, and had a long conversation with someone planning to set up a business exporting green beans to the US, and their beans were getting tested to an extreme degree and being rejected for…

Just Wikipedia. It cites two studies that found values of 8-13 mg and 3-32 mg per decaf cup, compared to regular which is 95-200. https://en.wikipedia.org/wiki/Decaffeination

The linked Wikipedia "study" is this science daily article:

https://www.sciencedaily.com/releases/2006/10/061012185602.h...

And that article links back to this UFL press release. I've clicked every link I can find and there's not an actual, published study to be found anywhere:

https://archive.news.ufl.edu/articles/2006/10/uf-experts-dec...

But even if there was, is a study from 20 years ago still relevant?

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#107

Post by rubzah »

For the health benefits, without some of the downsides, I believe it is preferable to drink coffee when you are not tired. This way you don't get a crash later, because there is no adenosine build-up (the 'tiredness' signaling molecule that caffeine blocks). I believe this also helps to prevent addiction, because there is also no up-regulation of adenosine receptors.

This works great if you drink coffee for the taste, rather than as a way to stay awake (which works in a pinch but is counter-productive over the long term).

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#108

Post by cout »

pjerem wrote: post #31
Bridged7756 wrote: post #24

Earlier quoted context omitted.

Not everything is dopamine. Maybe nitpicky on my end but it gets tiresome when everyone is just like dopamine this, dopamine that, when no one really understands neurotransmitters.

Haha, I viewed a video recently (in French) that said « dopamine is right-wing ». It was ironic but interesting : dopamine is viewed as THE neurotransmitter of motivation while in fact it’s only one part of the mechanism. But it’s the part everyone is bragging about because it supports the idea that you can control your dopamine levels and be responsible of your own motivation. The whole point of the argument was tha…

Are you saying that non-Parkinson's patients are taking L-DOPA as a supplement? If so, that's nuts.

Also dopamine is a precursor to noradrenaline, and serotonin levels are affected by numerous drugs, the most popular of which are antidepressants. That "supplements" for these neurotransmitters has more to do with how effectively they cross the blood-brain barrier and how they might disrupt the gut, since many chemicals in the brain do double duty through functions in both brain and gut.

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#109

Post by cout »

afc wrote: post #104
jorvi wrote: post #47

Earlier quoted context omitted.

Unfortunately the most flavorful methods (espresso, french press, moka) also raise your cholesterol. So sadly, no, coffee is not universally "good for you". Filtered coffee methods are though, as the filter absorbs the oils.

But filtered coffee is the most flavorful! No other method extracts the subtle nuances as well! P.s. I know it's subjective, just cringe on this claim of "the most flavorful" starting with espresso. :)

Yep, every method brings out a different nuance of coffee flavor, and any true coffee snob will likely own half a dozen or more items for brewing coffee.

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#110

Post by cout »

Jackpillar wrote: post #68
jorvi wrote: post #47

Earlier quoted context omitted.

Unfortunately the most flavorful methods (espresso, french press, moka) also raise your cholesterol. So sadly, no, coffee is not universally "good for you". Filtered coffee methods are though, as the filter absorbs the oils.

Sorry brother but the worry around cholesterol - especially in the context of the US - is not stemming from people drinking too much coffee. If you have high cholesterol there are 15 other things you should probably be cutting down on. This is similar to people who tell people to watch the sugar content in their fruit intake. No ones getting obese off fruit, the benefits outweigh the negatives tenfold.

While what you say is true, people carrying extra weight are often prediabetic and should be watching sugar/carb intake in the morning when blood glucose levels are already rising without food. That also happens to be one of the most popular times of day to consume fruit, which is why choosing a fruit with a lower glycemic index (or load) at breakfast is importance.
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