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CRISPR takes important step toward silencing Down syndrome’s extra chromosome

medicalxpress.com

101–110 of 155 posts

Re: CRISPR takes important step toward silencing Down syndrome’s extra chromosome

#101
post #83

Great achievement. Sometimes I imagine a world where the LLM-money, will and time was funneled into more aggressive CRISPR research and medical advances in general. If I want to go full sci-fi I even imagine cloning.

Cloning isn't even sci-fi or imaginary, just morally questionable and... variably legal (https://en.wikipedia.org/wiki/Human_cloning#Legal_status_of_...). Same goes for gene editing / designer babies / eugenics, which overlaps strongly with the subjects in this discussion.

Re: CRISPR takes important step toward silencing Down syndrome’s extra chromosome

#102

Earlier quoted context omitted.

In the first half of my comment, I explained that I don't think people should suffer. I'm just also aware that if everyone can pick their child's attributes, it could lead to a nation of blond-hair, blue-eyes kids

Would you pick blond hair, blue eyes for your kids? Would black people pick it? Asian?

I wouldn't, but I can imagine a lot of people would

Re: CRISPR takes important step toward silencing Down syndrome’s extra chromosome

#103
post #70

Earlier quoted context omitted.

Human women have stripey skin too, but you can't see it under normal light because unlike cats, skin tone in humans is not controlled by the X chromosome. https://www.youtube.com/watch?v=BD6h-wDj7bw&t=225s

That video seems to imply you can't see it under any light and the image there is pure visualization.

AFAIR this comes up visually when infected with certain diseases.

Re: CRISPR takes important step toward silencing Down syndrome’s extra chromosome

#104
post #89

I have very conflicted feelings about this sort of thing. On the one hand, Down's syndrome can make life very hard, for both the person with it, and their carers and the people around them. I can imagine that some people would have preferred it if they were able to "cure" it. I've often felt in the past that I would have preferred to have been born without autism and ADHD, and while I've been coping a little better w…

You got to weigh this against abortions for unborn children diagnosed (maybe even wrongly, the tests are really not that exact) with Down's syndrome. The slippery slope already began a long time ago probably.

By week 20 there is practically no chance you're not going to know if you're carrying a baby with downs or not unless you refuse all the modern screening/tests available.

NIPT tests can be done at week 8 and give a very high indicator that can be followed up with close monitoring/invasive tests at week 14-15 that give a 99% accuracy. That's hardly "are really not that exact".

Re: CRISPR takes important step toward silencing Down syndrome’s extra chromosome

#105

I have very conflicted feelings about this sort of thing. On the one hand, Down's syndrome can make life very hard, for both the person with it, and their carers and the people around them. I can imagine that some people would have preferred it if they were able to "cure" it. I've often felt in the past that I would have preferred to have been born without autism and ADHD, and while I've been coping a little better w…

Not to downplay your situation, but this is Down's syndrome we're talking about, so a whole menagerie of both physical and mental conditions, including, but not limited to: higher risk of epilepsy and heart failure, aside from almost universal infertility in men.

It's a serious disability even today decreasing life expectancy by 10-15 years.

One may have different opinions regarding the quality of life of these people while they're alive, but I think we can agree that 60 years is a short lifespan for a human.

EDIT: also main point of eugenics, which seems to be not widely understood, was that the state would decide both what kind of children are born and who gets to have them. It was not unheard of to take sufficiently "aryan"-looking newborns from their "inferior race" parents and give them to "master race" adoptive parents.

This lack of agency on part of biological parents is a core tenet of eugenics.

Re: CRISPR takes important step toward silencing Down syndrome’s extra chromosome

#106

I have very conflicted feelings about this sort of thing. On the one hand, Down's syndrome can make life very hard, for both the person with it, and their carers and the people around them. I can imagine that some people would have preferred it if they were able to "cure" it. I've often felt in the past that I would have preferred to have been born without autism and ADHD, and while I've been coping a little better w…

Of course gene editing has the potential to go very wrong, and will almost certainly go very wrong. But trisomy 31 is a well defined genetic defect with heavy consequences on the person having it and his or her entourage and there is no ethics preventing to correct the issue even if the technology used can be also used for nefarious means. It would be like not using dynamite for freeing miners in a collapsing mine because in the future there will be bombs made from dynamite targeting children.

Re: CRISPR takes important step toward silencing Down syndrome’s extra chromosome

#107

I have very conflicted feelings about this sort of thing. On the one hand, Down's syndrome can make life very hard, for both the person with it, and their carers and the people around them. I can imagine that some people would have preferred it if they were able to "cure" it. I've often felt in the past that I would have preferred to have been born without autism and ADHD, and while I've been coping a little better w…

What would be the difference between curing a fetus versus a newborn? Isn't editing out the bad gene better than just aborting gestation? For the person gestating too, since going through an abortion is psychologically damaging

Re: CRISPR takes important step toward silencing Down syndrome’s extra chromosome

#108

I have very conflicted feelings about this sort of thing. On the one hand, Down's syndrome can make life very hard, for both the person with it, and their carers and the people around them. I can imagine that some people would have preferred it if they were able to "cure" it. I've often felt in the past that I would have preferred to have been born without autism and ADHD, and while I've been coping a little better w…

[deleted]

Re: CRISPR takes important step toward silencing Down syndrome’s extra chromosome

#109
post #96

Earlier quoted context omitted.

I'm sorry to hear that. So would you like others to suffer from them as well if given the choice?

If they had the choice to not suffer, and they wanted to take it, then I think it's their decision to make, and not anyone else's

This is one of those situations where the child will likely never get the choice, for the same reasons we don’t require informed consent for being born or getting your diaper changed.

By the time they can make it, it’s too late.

Re: CRISPR takes important step toward silencing Down syndrome’s extra chromosome

#110
post #63

Earlier quoted context omitted.

Recognizing that certain mutations very blatantly reduce a person's quality of life and making it possible to revert those mutations does not require treating the people who have not had those mutations reverted as lesser. Thinking of them as lesser leads to a society that prefers to drag each other down instead of lifting each other up.

I don't know about this argument because they seem a lot happier than I am. That's not to say that it's unreasonable to value intelligence over happiness, but framing it as quality of life seems off.

I chose to call it quality of life because I don't think that simply being happy is enough to have quality of life, but I don't agree that it's about valuing intelligence over happiness.

It's a condition they, and their family, have to live with their entire life. You can't really be permanently sad about a condition you have literally been born with and can't expect to change.

Meanwhile, there are conditions that significantly decrease quality of life even though one's intelligence is unaffected. I think the factor is better described as choice. There are a large number of things a person with Downs just does not have the choice to do differently.

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