Great achievement. Sometimes I imagine a world where the LLM-money, will and time was funneled into more aggressive CRISPR research and medical advances in general. If I want to go full sci-fi I even imagine cloning.
CRISPR takes important step toward silencing Down syndrome’s extra chromosome
101–110 of 155 posts
Re: CRISPR takes important step toward silencing Down syndrome’s extra chromosome
#102Earlier quoted context omitted.
In the first half of my comment, I explained that I don't think people should suffer. I'm just also aware that if everyone can pick their child's attributes, it could lead to a nation of blond-hair, blue-eyes kids
Would you pick blond hair, blue eyes for your kids? Would black people pick it? Asian?
Re: CRISPR takes important step toward silencing Down syndrome’s extra chromosome
#103Earlier quoted context omitted.
Human women have stripey skin too, but you can't see it under normal light because unlike cats, skin tone in humans is not controlled by the X chromosome. https://www.youtube.com/watch?v=BD6h-wDj7bw&t=225s
That video seems to imply you can't see it under any light and the image there is pure visualization.
Re: CRISPR takes important step toward silencing Down syndrome’s extra chromosome
#104I have very conflicted feelings about this sort of thing. On the one hand, Down's syndrome can make life very hard, for both the person with it, and their carers and the people around them. I can imagine that some people would have preferred it if they were able to "cure" it. I've often felt in the past that I would have preferred to have been born without autism and ADHD, and while I've been coping a little better w…
You got to weigh this against abortions for unborn children diagnosed (maybe even wrongly, the tests are really not that exact) with Down's syndrome. The slippery slope already began a long time ago probably.
NIPT tests can be done at week 8 and give a very high indicator that can be followed up with close monitoring/invasive tests at week 14-15 that give a 99% accuracy. That's hardly "are really not that exact".
Re: CRISPR takes important step toward silencing Down syndrome’s extra chromosome
#105I have very conflicted feelings about this sort of thing. On the one hand, Down's syndrome can make life very hard, for both the person with it, and their carers and the people around them. I can imagine that some people would have preferred it if they were able to "cure" it. I've often felt in the past that I would have preferred to have been born without autism and ADHD, and while I've been coping a little better w…
It's a serious disability even today decreasing life expectancy by 10-15 years.
One may have different opinions regarding the quality of life of these people while they're alive, but I think we can agree that 60 years is a short lifespan for a human.
EDIT: also main point of eugenics, which seems to be not widely understood, was that the state would decide both what kind of children are born and who gets to have them. It was not unheard of to take sufficiently "aryan"-looking newborns from their "inferior race" parents and give them to "master race" adoptive parents.
This lack of agency on part of biological parents is a core tenet of eugenics.
Re: CRISPR takes important step toward silencing Down syndrome’s extra chromosome
#106I have very conflicted feelings about this sort of thing. On the one hand, Down's syndrome can make life very hard, for both the person with it, and their carers and the people around them. I can imagine that some people would have preferred it if they were able to "cure" it. I've often felt in the past that I would have preferred to have been born without autism and ADHD, and while I've been coping a little better w…
Re: CRISPR takes important step toward silencing Down syndrome’s extra chromosome
#107I have very conflicted feelings about this sort of thing. On the one hand, Down's syndrome can make life very hard, for both the person with it, and their carers and the people around them. I can imagine that some people would have preferred it if they were able to "cure" it. I've often felt in the past that I would have preferred to have been born without autism and ADHD, and while I've been coping a little better w…
Re: CRISPR takes important step toward silencing Down syndrome’s extra chromosome
#108I have very conflicted feelings about this sort of thing. On the one hand, Down's syndrome can make life very hard, for both the person with it, and their carers and the people around them. I can imagine that some people would have preferred it if they were able to "cure" it. I've often felt in the past that I would have preferred to have been born without autism and ADHD, and while I've been coping a little better w…
Re: CRISPR takes important step toward silencing Down syndrome’s extra chromosome
#109Earlier quoted context omitted.
I'm sorry to hear that. So would you like others to suffer from them as well if given the choice?
If they had the choice to not suffer, and they wanted to take it, then I think it's their decision to make, and not anyone else's
By the time they can make it, it’s too late.
Re: CRISPR takes important step toward silencing Down syndrome’s extra chromosome
#110Earlier quoted context omitted.
Recognizing that certain mutations very blatantly reduce a person's quality of life and making it possible to revert those mutations does not require treating the people who have not had those mutations reverted as lesser. Thinking of them as lesser leads to a society that prefers to drag each other down instead of lifting each other up.
I don't know about this argument because they seem a lot happier than I am. That's not to say that it's unreasonable to value intelligence over happiness, but framing it as quality of life seems off.
It's a condition they, and their family, have to live with their entire life. You can't really be permanently sad about a condition you have literally been born with and can't expect to change.
Meanwhile, there are conditions that significantly decrease quality of life even though one's intelligence is unaffected. I think the factor is better described as choice. There are a large number of things a person with Downs just does not have the choice to do differently.