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Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

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101–110 of 122 posts

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#101

Earlier quoted context omitted.

Have you tried L-theanine? I also get panic attacks with weed, but L-theanine seems to help keep them at bay.

I have tried l-theanine, didn't do anything that I could tell. But fortunately there's a much better solution for those of us who get anxiety from weed, it's called "don't smoke weed".

Abstaining is not a cure for rude smugness, apparently

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#102

Earlier quoted context omitted.

Yeah, people complain about opiates but even beta-blockers or antihypertensive agents have rebound symptoms if you stop taking them. People really just love to see others suffer instead of allowing them to use opiates. NSAIDs are known to kill your stomach, your kidney, your liver, and your heart, whereas opiates do not. And they are ineffective for a lot of people's chronic pain, on top of that.

it's truly a shame that wilful ignorance is societally acceptable. psychopathy is a scale we all fit on; everyone modulates their empathy to varying degrees, otherwise we'd be bonobos. the downtrodden of society deservedly get that moniker - for being walked over. im happy on your behalf that you are conscious enough to know how to treat yourself correctly, and it truly is a shame that others in your position aren't…

> either they have no clue what its like to hurt

I was thinking the same thing. There is no way people who have chronic pain are saying these things. And if you think about it, it is sickening that people who are fine and do not have chronic pain are the ones dismissing a painkiller, or are trying to dictate someone else's life because they heard opiates are bad (opioid crisis, war on drugs).

And yeah, everyone will be okay with it. Sometimes I really wish people were in my shoes... We need more people experiencing it, otherwise we really are f....d (because they lack empathy, it seems). Good comparison to schizophrenia, by the way.

I really hope that you are wrong though. :/

(BTW, any way I could reach out to you?)

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#103
post #83

Earlier quoted context omitted.

although the study is often labelled irreplicable, i do still believe in rat park. opiates are not evil in and of themselves; rather, society forms a structure around which the use of opiates easily becomes more alluring than contributing to said society. consequently, those in chronic pain are often forced to suffer needlessly by being deprived of relief, so that societal productivity is maximized. the real miracle…

Opiates form a quick and nasty addiction. People in constant pain (as in, 24/7 or even most of the day, every day) need to take ever increasing doses to get the same level of pain relief. You would be surprised how many folks are like that, and not only 70+ years old. It takes few weeks to form a lifelong addiction that can never be fully shed and will form a permanent crack or weakness in one's personality. What all…

Surely there many substances that some people cannot do without. Treat opiates as just another one of those. They are cheap to manufacture. Addicts can hold down a job, pay taxes etc just like the rest of us. So why not?

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#105

Man, too bad weed gives me bad panic attacks. Alzheimers is the scariest disease I know so maybe if the studies pan out in time and it becomes a standard preventative, I might consider trying again. But somehow I doubt it will be found to be that effective.

Try really low doses.

I hate being truly high, but a weed "buzz" is great for falling asleep, especially when ill (I often suffer more from severe lack of sleep than from any of the other effects of whatever common virus or bacterial infection I manage to catch). It doesn't take much for a lightweight (a status I have carefully maintained) to reach "buzz" territory, and only a little more to reach "properly high" territory (which, again, I find rather unpleasant).

I'd suggest edibles and starting at 2mg, max, for a first attempt, working up 1mg at a time (in a totally different session, on another day!) until desired effect achieved. Like I've been at this a while and a 10mg gummy, which is a common single-gummy dose size in many states, will take me past where I ever want to be. 5ish is about right for me, maybe up to 8 if I need a stronger kick for some reason (like, say, I'm sick and need to get high enough to sleep most of the night despite significant sinus discomfort or throat pain)

FWIW I also doubt the anti-Alzheimer's stuff will pan out, or if it does, it'll be some targeted therapy with specific chemicals, which won't look a lot like any products from a dispensary.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#106

Earlier quoted context omitted.

If the doses of cannabis required to cure alzheimers would be high enough doses to destroy the rest of one's brain, it makes this finding not very useful, similar to the idea of curing alzheimers by destroying one's brain/

But the studies are pervasive. For example, the (flawed) study that found that one cup of wine with each meal was healthier that no alcohol at all is still quoted today, and still "reproduced" in other studies that make the same claim but adding a clause of "given that you also [do good amount of exercise|eat very healthy|are in perfect health already]". Or the flawed studies that Soffriti and Belpoggi pushed (some o…

Yup. There's definitely a pattern and it seems like an obvious consequence of the structure of incentives.

If you make a product you can make a study that shows it has some kind of benefit in some specific way, even if it probably causes more harm in other ways that are less obvious, and then you can sell it. Media will spread around your study especially if it shows something that will be a bit click-baity, and any study or discussion of the possible downsides will get far less attention.

This is also why basically every edible plant has some article saying it's a "super food" etc etc.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#107

I only had time to skim the paper. Notably, the effect is concentration dependent and required high concentrations of THC. The chart shows it really starting in the 0.1uM range and then taking off in the 1uM range. I don’t know what levels are achieved during normal use but I did find some studies that successfully killed a lot of hippocampal neuronal cells after 6 days at 1uM range. So the levels of THC observed in…

I suppose this might be why Willie Nelson is still doing pretty good these days...

It's stress. I'm convinced of it. Little old lady is smoking cigars at 105 years old because she's stress-free. Willie Nelson is looking sharp for his age because he's low-stress. If it helps reduce your personal stress, perhaps...PERHAPS, it's a good thing.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#108
post #55
post #14

Earlier quoted context omitted.

I've tried everything and I still get panic attacks. I used to love smoking a small hitter about an hour before bed. I've always had insomnia and that was the one thing that actually helped me sleep. When it was illegal, I loved it. I would smoke 2 or 3 times a week just for sleep, and I was healthy and happy. . . Because sleep is important, and I never wanted to take sleeping pills because dependency. Now that it's…

How low was the % of THC in the Charlotte’s Web? Full spectrum hemp (~0%) definitely feels like the answer, here!

It's like 0.3%. so pretty much as low as you can get while still having some THC.

Does hemp have the same relaxing qualities?

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#109
post #21
post #14

Earlier quoted context omitted.

I've tried everything and I still get panic attacks. I used to love smoking a small hitter about an hour before bed. I've always had insomnia and that was the one thing that actually helped me sleep. When it was illegal, I loved it. I would smoke 2 or 3 times a week just for sleep, and I was healthy and happy. . . Because sleep is important, and I never wanted to take sleeping pills because dependency. Now that it's…

Have you tried edibles or another method than smoking?

Yes and they cause panic attacks, but they last even longer. So that's cool.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#110
post #39
post #14

Earlier quoted context omitted.

I've tried everything and I still get panic attacks. I used to love smoking a small hitter about an hour before bed. I've always had insomnia and that was the one thing that actually helped me sleep. When it was illegal, I loved it. I would smoke 2 or 3 times a week just for sleep, and I was healthy and happy. . . Because sleep is important, and I never wanted to take sleeping pills because dependency. Now that it's…

Wow, Charlottes Web is such unique strain. I'm always on another planet no matter what the THC is advertised. I feel like that strain is for EXPERTS. You can always mold it to the vibe you are aiming to reach in that present (ofc in the appropriate environments). Do you feel like the anxiety just the cascaded result of ... "poor planning" over an extended, day-over-day staggering, sleep-deprived, period of time? I co…

Charlotte's Web is what I picked because it's so so so low THC content. I'm usually pretty on the ball, and the things I have panic attacks about aren't things that actually bother me when I'm sober. It's like I become hyper critical of myself and over analyze every decision and conversation I've ever had. It's not good.
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