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Your hypothesis here though is full of complicating factors. For example >I stopped drinking heavily and using other drugs, i.e. marijuana Like the primary change you made was to cut out using a whole bunch of drugs with known, significant neurological effects.
I think the "and" is for "stopped (both) A and B"
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What did you do for heartburn? Just looking for ideas. I noticed reducing gluten helped me personally a lot
not the commenter but I bake my own soda bread and found that i was getting heartburn from the salt that was in the recipe. once i eliminated that i could eat as much as i wanted. I also cannot eat salt preserved potato chips on consecutive days.
I had a colonoscopy and had to empty my system.
I had 1/2 gallon of this fluid to drink the night before, and the other 1/2 gallon to drink the day of. At that point my digestive system was empty.
I will say with an empty system I felt energized and a lot more clearheaded.
I wonder if doing this from time to time is helpful to your system, and furthermore if eating smaller portions would be helpful to my energy levels.
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Serotonin produced in the gut doesn’t get into your brain. This factoid is repeated everywhere but it’s misleading without knowing that gut serotonin is a different pool than brain serotonin and they have different functions. The brain synthesizes its serotonin locally within the brain.
Serotonin from the gut affects vagal neurons. They carry that signal directly to the brain. That has a significant effect on up and down regulation of mood and arousal.
The fact that we both use Salesforce does not matter. It’s internal and doesn’t mean anything outside the company. Both the brain and gut re-used the molecule for their own internal signaling. Evolutionarily it was cheaper to use an existing molecule.
To the brain, the invoice is just “I’m full” or “I’m hangry.” It doesn’t care how much serotonin the gut had to produce internally to issue that “invoice.” The brain will produce its own serotonin from the signal of satiety but it won’t give you any more than you can from just feeling full.
The paper is open access. The discussion does a fine job of providing a full context for interpreting their findings.
> They showed that colonizing the guts of young mice with this bacterial species inhibited their performance on the object recognition and maze escape tasks, and that this deficit correlated with a reduction of activity in the hippocampus.
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I believe this research is totally true-- I had a lot of memories come back after 1. I stopped drinking heavily and using other drugs, i.e. marijuana 2. managed my diet to avoid heartburn without medication 3. schedule my meals so it was easier to sleep at night (always eat something for breakfast when I wake up) I did not need any "poo infusion" or anything. I had a gal bladder removal that didn't fix the problems t…
> 1. I stopped drinking heavily and using other drugs, i.e. marijuana Heavy alcohol use and marijuana are both known to impact memory and recall directly. Discontinuing both of those explains changes in memory. Attributing this to microbiome changes does not follow.
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I would recommend the site https://gutbrainaxistherapeutics.com for learning more about Microbiota Transplant Therapy (MTT) and its opportunities, especially for Autism and Pitt-Hopkins Syndrome.
There is zero evidence that poop transplants have any effect on autism, let's be clear here.
More recently, a study finds The modulation of the gut microbiota using MTT in ASD has shown beneficial and long-term effects on GI symptoms and core symptoms of autism[3]
[1] https://gutbrainaxistherapeutics.com/pipeline/#clinical-tria...
[2] https://link.springer.com/article/10.1186/s40168-016-0225-7
[3] https://www.tandfonline.com/doi/abs/10.1080/19490976.2025.24...
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I think mainstream is mostly looking at the microbiome stuff wrong. Your microbiome is the downstream proxy of good lifestyle habits, not generally something to directly manage. Good diet, exercise, reducing stress, and sleeping well will improve digestion and all the downstream variables like microbiome, physical health, and mental health. This is basic ecology, the bacterial population dynamics in your colon are a…
It certainly anecdotal, but feels like you can positively effect your gut microbiome for example by riding a horse. Ive read research about how other mammals can share their microbiomes with humans, if its not the horses biome then what is it that so satisfingly calming post ride. Would love to be enlightened. Ride a horse if you need to destress, amazing creatures.