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Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

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Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#101

Post by omgwtfbyobbq »

nradov wrote: post #98
bryant wrote: post #65

Earlier quoted context omitted.

It's a pretty sad reflection of the times that there's a need to create a throwaway account to talk about long COVID symptoms, but this is a good personal anecdote to draw attention to what's likely happening. In my case, I only caught covid once - somepoint last year just before I would've gotten the updated booster. It took me well over a year to stop having acute pulmonary issues, and my lung performance is down y…

It ought to be possible to test that hypothesis by comparing publicly available race results for the same athletes on the same courses before and after the pandemic relative to the expected age-related performance loss. Anecdotally as an age-group endurance athlete I'm not seeing any big declines in myself and my friends so I'm highly skeptical that 20% were "ravaged". The actual incidence of significant loss of pulm…

You can test it for endurance athletes, but not necessarily for the population at large.

If long COVID disproportionately affects people who are sedentary, then you won't see that in endurance athlete performance.

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#103

Post by Llamamoe »

swed420 wrote: post #80
Llamamoe wrote: post #40

Earlier quoted context omitted.

It takes very severe disability for it not to be brushed off as depression, anxiety, burnout, or blamed on lifestyle. Additionally, a lot of those numbers are based on earlier strains of COVID, which were much more severe. I suspect the 1/5 figure is largely true for "has some degree of cardiovascular damage and worsened general health after COVID", but the number of people actually disabled by the condition is much…

> Additionally, a lot of those numbers are based on earlier strains of COVID, which were much more severe. Long COVID associated with SARS-CoV-2 reinfection among children and adolescents in the omicron era https://www.thelancet.com/journals/laninf/article/PIIS1473-3... (The same omicron era the media originally claimed was "not as bad as previous variants." Perhaps not in the acute phase, but as we've seen, that's t…

There's more to air quality than HEPA filters. In-line far UV sterilisation, ventilation to reduce rebreathing and CO2 levels, and HEPA might not be enough as a single-building intervention, but it would almost definitely change disease spread dynamics if deployed world/nation wide.

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#104

Post by Retric »

nradov wrote: post #98
bryant wrote: post #65

Earlier quoted context omitted.

It's a pretty sad reflection of the times that there's a need to create a throwaway account to talk about long COVID symptoms, but this is a good personal anecdote to draw attention to what's likely happening. In my case, I only caught covid once - somepoint last year just before I would've gotten the updated booster. It took me well over a year to stop having acute pulmonary issues, and my lung performance is down y…

It ought to be possible to test that hypothesis by comparing publicly available race results for the same athletes on the same courses before and after the pandemic relative to the expected age-related performance loss. Anecdotally as an age-group endurance athlete I'm not seeing any big declines in myself and my friends so I'm highly skeptical that 20% were "ravaged". The actual incidence of significant loss of pulm…

> you'd have to throw out the slower finishers who maybe weren't trying hard. But if there's a significant correlation then it ought to show up.

Poor performers and no shows are exactly the population you’re looking for. To be clear the argument isn’t about a 10% decline across the board among people with long COVID as there’s non cardio pulmonary symptoms like brain fog, loss of smell, and difficulty sleeping.

If 80% of the fit population had COVID, 20% of them had long COVID, and half the people with long COVID had a 10% decline in race performance. That’s something like an overall 0.8% drop of performance assuming nobody dropped out or joined, but again you’re loosing people on both sides who were most impacted. Thus I’d be highly skeptical of finding an actual connection here rather than something else that impacts more people.

A more useful approach is to take a cohort of people who raced in 2019 and track what happened to every single one of them specifically.

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#105

Post by Llamamoe »

notmyjob wrote: post #91
clanky wrote: post #48

Earlier quoted context omitted.

The one Thai prospective study that I saw on this subject (the only one I ever found which measured biomarkers of heart damage like troponin before and after injection, which is utterly shameful), estimated a rate of heart damage in adolescent males in the range of 1-3%. So even that would be nowhere near enough to reach the 1/5 number.

I suspect many people commit the grave sin of mixing data sources to derive percentages, which seems almost impossible not to do in this case. I also strongly suspect that rates of infection (the denominator in question) were inflated to some extent during the pandemic as insurers and hmo were incentivized to detect covid even when it may not have been the primary reason for presenting. There were also disincentives…

The reported rates might have been inflated compared to what people presented with, but wastewater tracking and excess death measures all suggest that as a whole, infections were severely under-counted, possibly by a factor of up to over 2x.

Majority of the studies on myocarditis after vaccination found very low rates, with close to zero moderate to serious cases, and a full return to baseline of whatever the metrics studied were, I don't remember.

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#106

Post by Llamamoe »

notmyjob wrote: post #46
Llamamoe wrote: post #40

Earlier quoted context omitted.

It takes very severe disability for it not to be brushed off as depression, anxiety, burnout, or blamed on lifestyle. Additionally, a lot of those numbers are based on earlier strains of COVID, which were much more severe. I suspect the 1/5 figure is largely true for "has some degree of cardiovascular damage and worsened general health after COVID", but the number of people actually disabled by the condition is much…

And the lipid nanoparticle based Covid prevention shots caused myocarditis in some younger males, so earlier incidence of cardiovascular complications vs. the present (when most people especially younger healthy males are choosing not to take updated boosters) would correlate with that as well.

They did but if you go through the actual studies, the incidence of myocarditis was low, and almost all cases were non-serious, with no measured long-term impacts.

Further, the studies on long COVID incidence in vaccinated vs unvaccinated people suggested that the rates in vaccinated individuals were lower, though iirc it was only by something like a third or half. (among people who were symptomatic, at least, the total protective effect was likely greater)

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#107

Post by tehjoker »

tgsovlerkhgsel wrote: post #10

The paper claims that 1/5 of people experience Long COVID after an infection. Given that approximately everyone has caught COVID by now, this does not track with how rarely I've heard of people with it. Wikipedia lists much lower numbers on https://en.wikipedia.org/wiki/Long_COVID (6–7% in adults, ~1% in children, less after vaccination.) and seems to use a more liberal definition than this paper, as it mentions "Mos…

That spread has been consistent in the literature for a long time. It depends on what symptoms you are looking for. Frankly, I trust the consistent message from the literature. Long covid is extremely prevalent but not always visible

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#108

Post by nradov »

jancsika wrote: post #90
MontyCarloHall wrote: post #60

Earlier quoted context omitted.

Couldn’t it be the other way round, that changes in health caused by other external factors erroneously get blamed on COVID? For instance, a disproportionate amount of long COVID cases are reported by women between the ages of 40 and 60, the exact age range when most women experience menopause [0]. Menopause can cause brain fog, fatigue, and other symptoms that mirror those of long COVID. Since pretty much everyone h…

> Couldn’t it be the other way round, that changes in health caused by other external factors erroneously get blamed on COVID? It is possible, but not to the degree that all long Covid cases are being confused with external factors. > Menopause can cause brain fog Additionally, long Covid can cause brain fog. This was shown in brain scans from a popular HN post about a research paper just yesterday: https://news.ycom…

You can't see "brain fog" on any imaging scan. That study didn't demonstrate any such causation. At most you can establish a correlation between certain imaging patterns and patient symptoms (which are notoriously noisy for any sort of behavioral health condition).

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#109

Post by hbs18 »

withinboredom wrote: post #95
colechristensen wrote: post #84

Earlier quoted context omitted.

Before antibiotics, nontrivial wounds were often death sentences because of infection.

I never needed an antibiotic to live from these wounds. I’ve needed them from other things (almost died from strep) but not wounds.

You live in a very different world compared to one before antibiotics.

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#110

Post by withinboredom »

hbs18 wrote: post #109
withinboredom wrote: post #95

Earlier quoted context omitted.

I never needed an antibiotic to live from these wounds. I’ve needed them from other things (almost died from strep) but not wounds.

You live in a very different world compared to one before antibiotics.

If death were so guaranteed from injuries, I doubt we’d have survived as a species.
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