101–110 of 214 posts
Why not just lose weight by eating less? I know that sounds like a dumb question. But genuinely, aren’t you just paying money to… not spend the money on food instead?
This is like asking why ADHD patients don’t just get over it by focusing more.
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This is like asking why ADHD patients don’t just get over it by focusing more.
I would state it in a kinder way maybe, but at the end of the day that's basically what you have to do? ¯\_(ツ)_/¯
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what could go wrong with screwing with the neurochemical reward system of the entire population We already know what can go wrong. We already did that decades and decades ago. Sugar, for example. Aside from so many foods being laced with it, you can now simply walk into a store and buy a kilogram of sugar and eat it. So many other examples. That ship sailed a long long time ago. All we can do now is nudge the dial th…
Because you can buy sugar from the store, having the US subsidize ozempic for for the entire population makes logical sense. Got it.
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Novo Nordisk's market cap is $500 B, mostly on the basis of GLP-1 drug profits, and the US' entire discretionary budget is $1,700 B. Even if Denmark would allow the sale, and even if somehow the US did not need to pay a premium to shareholders (typical in acquisitions), that would still be a very substantial expenditure.
The correct unit of measurement here is Iraq wars. Purchasing NN Would cost roughly 0.2 Iraq wars.
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> So far, I haven't seen much evidence that GLP-1s have a positive effect on people who aren't overweight. It is licensed, tested, and sold as a Type-2 Diabetes medication. Are you claiming it is ineffective for that purpose? Or if you're under the impression that no healthy weight T2 Diabetics exist, I have some news for you... It is also being studied for: opioid addiction, alcoholism, Alzheimer's/Parkinson’s, Card…
Don't dismiss the most important question -- does semaglutide really have any effects outside its current intended use for diabetes and weight loss? In other words, would a thin, metabolically healthy person benefit from taking semaglutide? So far, all of the wonderful benefits from taking the drug seem to be explainable by reduced caloric intake / weight loss / better glucose control in overweight and/or diabetic pe…
That's what this thread is about; and multiple other studies looking at different diseases/illnesses/addictions. Time will tell. It is currently approved for T2 Diabetes and Obesity.
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I’ll make my usual response: we know that being obese is basically the worst possible thing you can do to yourself, and the longer you are, the worse it is. The side effects are going to be pretty awful just to negate that, much less all the other things they seem to be good for.
>> being obese is basically the worst possible thing you can do to yourself Lol. I can think of dozens of worse things. Drinking. Cocaine addiction. Meth. Winding up in prison for some reason. Riding a motorcycle without a proper helmet. Getting into a plane flown by Harrison Ford. Even simple unprotected sex can lead to massive medical problems. Ever looked up the average life expectancy of professional athletes, es…
Being obese is probably worse for you. NAFLD has long eclipsed alcohol related liver issues.
> Even simple unprotected sex can lead to massive medical problems
Even treated HIV is probably less of a risk to your long term health than obesity, but I'm not a doctor.
> Cocaine addiction. Meth
OK, yes, there are illegal drugs that are going to be worse for you than being fat.
I'll rephrase:
Being obese is basically the worst possible thing you can do to yourself that affects a huge portion of the population of the western world.
Very very few people are riding motorcycles without a helmet, even fewer are getting into planes flown by harrison ford, only a tiny tiny tiny fraction of the population even has the option of being a professional athlete.
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> There's the rub. We have not been prescribing semaglutide very long, and I won't trust it until we've had enough time to suss out long term side effects. We've been prescribing GLP-1s for almost 20 years now. Not to say they all should behave identically, but from a Bayesian inference perspective these things really do appear to be quite safe.
https://www.drugwatch.com/legal/ozempic-lawsuit/
This adds literally zero information.
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I have been on compounded GLP-1 for a month, prior to this I was a highly functional alcoholic, basically starting drinking after work every night and going until I passed out. I've drunk well over 50 beers (probably more) a week for the last 20 years. I have not had a drink since going on it. I have been reading obsessively about this drug since going on it. I have been fortunate enough not to suffer side effects on…
> barring any life threatening long term side effects There's the rub. We have not been prescribing semaglutide very long, and I won't trust it until we've had enough time to suss out long term side effects. My father was on a long-term maintenance dose of immunosuppressant (I think prednisolone, but I could be misremembering) following his kidney transplant. When it was first prescribed to him, the long term side ef…
This is fair. But I'll ask you this: how long would it take for you to trust it? Assuming there are no side effects beyond what we know now, which are:
* gastroparesis is a small number of patients
* elevated thyroid cancer risk in mice
* nausea and general uncomfortableness when taking it (some percentage, not all)
* muscle and bone loss which seems to be roughly on par with any rapid weight loss approach
* a small percentage of people develop malaise, anhedonia and suicidal ideation
* a propensity to gain some percentage of weight back and/or relapse in addictive behavior when going off the drug
These are the side effects we know about with over a decade of prescribing GLP-1 agonists. Assuming these continue to be the primary side effects, how long would you wait until you are comfortable in trusting they are the only ones?
Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.
Novo Nordisk's market cap is $500 B, mostly on the basis of GLP-1 drug profits, and the US' entire discretionary budget is $1,700 B. Even if Denmark would allow the sale, and even if somehow the US did not need to pay a premium to shareholders (typical in acquisitions), that would still be a very substantial expenditure.
This would be amazing if true, but the lack of randomization makes me nervous. What if, like, patients who are about to get Alzheimer's are less aggressive about asking their doctor for semaglutide (which has been in shortage for a while), and that explains the trial results?
https://www.nbcnews.com/science/science-news/alzheimers-theo...
This publication is bogus. It is too soon to know if there is any benefit at all from Semaglutide.