Earlier quoted context omitted.
Not all GUIs are just a graphical wrapper for a CLI. But in general sure, understanding the tech behind helps.
No doubt, if you're working in AutoCAD, there's no command line that you need to understand first. But then again, if you're working in AutoCAD, you'd never say "I used to work in CLI only, now I use GUIs more and more". Clearly they meant GUIs that have CLIs behind, or at least CLI alternatives.
And if you were using AutoCAD in the 80's you can say exactly that you used to use the CLI only!