101–110 of 276 posts
It's interesting that brain hypersynchronicity is a known source of epileptic seizures (among other things). This potentially could be a treatment for this specific problem. See e.g. * https://www.sciencedirect.com/science/article/pii/S089662731930964X * https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2010.02805.x
This concerns Functional Connectivity[0], which is basically a measure of how temporally correlated regions are; those that fire in sync or in a strongly correlated pattern are functionally connected. Essentially, the TL;DR of this study is that psilocybin's 5-HT2A agonism seems to reduce synchronized FC activity not just in neurons but the whole brain: psilocybin makes parts of the brain overall that otherwise work…
I think the fact that nobody knows how to deal with negative correlations in functional connectivity takes away from the validity of the whole concept. People literally throw out negatively correlated voxels/ROI's. This, on top of the fact that functional connectivity is only related to physical connectivity in the abstract. (it's about the correlated time series activity in pixels over time, and isn't bound by any c…
Earlier quoted context omitted.
Many countries in Europe have tons of older hunting guns, on top of newish guns for... personal protection? Sport? Or whatever reason people feel the need to have them. Tens of millions as per wikipedia [1]. Also check other countries and continents. A very valid argument. [1] https://en.wikipedia.org/wiki/Estimated_number_of_civilian_g...
In most European countries you have to store the firearm in a locked safe, often with the bolt removed or the weapon disassembled and - quite often - with the ammunition stored separately in another locked container/safe. It’s a lot more “steps to take” to commit suicide than “take the weapon from your nightstand and shoot yourself”, given you have to unlock usually more than one safe/lockbox.
While it's amusing in the short term, the long term side effects for me were awful. I felt like my brain was slow and unfocused, I was no longer quick in conversation or able to concentrate as well as usual, I felt disconnected from myself, sort of like when you recall a memory so old that it seems like it belongs to someone else, I had a headache for almost 3 weeks. Throwing this in here as there are a fair few "dud…
Mushrooms are very contradictory in their nature to the modern "cog in the machine" lifestyle. It's a bit like being subjected to a software fuzzer. I imagine if learning from one's inputs, one will be afterwards less sure of concepts one was very sure about, but also less sure about concepts thought previously to be impossible. That will surely increase cognitive load, especially when one's life is pretty straightfo…
Before a controlled high dose Psilocybin experience I "felt" my emotions: Anger, Fear, Frustration.
Afterwards, I gained the ability to observe and "catch" my emotions in-flight. Not sure if it was neuroplasticity induced by the substance, or "you don't know what your brain can do until you know it".
I liken it to previously having Ring 1 access to my thoughts, now I have Ring 0 access.
Definitely persistent: DRAMATIC improvement in my happiness and wellbeing.
YMMV
Earlier quoted context omitted.
As I said in another post, the mental illness is not the issue here, the immediate access to a gun while blasted on shrooms is.
At least 42% of Americans live in a household with a gun so it isn't particularly useful to write off the anecdote.
It's interesting that brain hypersynchronicity is a known source of epileptic seizures (among other things). This potentially could be a treatment for this specific problem. See e.g. * https://www.sciencedirect.com/science/article/pii/S089662731930964X * https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2010.02805.x
Doubtful. Shrooms cause seizures.
LSD is better, sorry :/
Psilocybin and LSD are both psychedelics and 5-HT2A agonists. Even though the study uses psilocybin, the findings should apply to LSD too.
Extrapolation of biological effect based on the receptor affinity of a ligand is a pretty crude hypotheses.
This concerns Functional Connectivity[0], which is basically a measure of how temporally correlated regions are; those that fire in sync or in a strongly correlated pattern are functionally connected. Essentially, the TL;DR of this study is that psilocybin's 5-HT2A agonism seems to reduce synchronized FC activity not just in neurons but the whole brain: psilocybin makes parts of the brain overall that otherwise work…
Yeah, this is super interesting. The obvious follow up for me is what implication this desynchronization has on cognition. People who have done a lot of psilocybin tend to be quite a bit 'different' at least in my experience—they tend to be more reserved, maybe a bit more thoughtful, slower, introspective, etc. But what causes this change in personality? People who have done a lot of psilocybin seem to be a lot less…
Finally, there will be a great deal of individual differences. One story will not fit all of us.
It's interesting that brain hypersynchronicity is a known source of epileptic seizures (among other things). This potentially could be a treatment for this specific problem. See e.g. * https://www.sciencedirect.com/science/article/pii/S089662731930964X * https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2010.02805.x
Doubtful. Shrooms cause seizures.
Earlier quoted context omitted.
Doubtful. Shrooms cause seizures.
Sources?
Couldn't find any data at the time. Tried to get them to submit experience reports on erowid so that there would be some data out there, but they didn't want to put anything about it in writing.