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Low and moderate alcohol consumption not associated with increased mortality

jamanetwork.com

101–108 of 108 posts

Re: Low and moderate alcohol consumption not associated with increased mortality

#101

Earlier quoted context omitted.

Average body mass would be my guess.

So we could tease this out by taking 90-110kg men and comparing to 90-110kg women?

Seems reasonable. Or do the whole analysis with the alcohol consumption adjusted per kg and see if the gender difference goes away.

Re: Low and moderate alcohol consumption not associated with increased mortality

#102
Every centenarian in Bulgaria is a moderate Rakia (a type of brandy/schnapps) drinker! Of course, I am fully aware of the survivorship bias, and I'm not saying we should drink Rakia, but these studies are trying to push a narrative, they do not accept the richness of human metabolism!

Re: Low and moderate alcohol consumption not associated with increased mortality

#104
post #67
post #49

Earlier quoted context omitted.

Given that yeast leavened bread is around 1.5% alcohol and food can naturally ferment in your gut, it’s nearly certain that there is in fact some safe amount of regular alcohol intake that’s well within the bounds of homeostasis and thus as safe as anything can be. But that’s not how people drink is it? People use alcohol to intentionally disrupt homeostasis. It’s certainly plausible that there is no safe regularly t…

All alcohol has carcinogenic properties. That's just a simple fact. Cancer is bad. Anything that increases our chances of cancer is bad. And considering alcohol has no beneficial qualities when consumed, it's technically all downside. So while bread may have some alcoholic content, it has other beneficial properties. As does the sun, even though it is a huge carcinogen. However, I do like to remind people, that while…

It seems extremely reductive to say people don’t get positive effects from alcohol. That’s why they drink it!

Re: Low and moderate alcohol consumption not associated with increased mortality

#105
post #94
post #86

Earlier quoted context omitted.

Yes, this is interesting research. If I was going to drink again, it would be limited to red wine and beer (which contains other beneficial compounds). Personally I just take pterostilbene, which is structurally similar to resveratrol and has similar health benefits but is much more bioavailable. Cognitive decline and dementia are multifactorial, and with alcohol consumption there are trade-offs between neuronal deat…

May I suggest that, if you have't already, you get a 23andme. "While light alcohol consumption has been associated with a decreased risk of AD in general [127], this relationship does not appear to hold in ApoE4 carriers. Consumption of any amount of alcohol may increase the risk of AD[Alzheimer's disease] for ApoE4 carriers [128,129,130]. In one study, both light and moderate alcohol consumption were associated with…

Thank you, that's super interesting information I wasn't aware of. I did get 23andMe back in 2009 and was able to locate the ApoE4 SNP. For anyone with 23andMe or WGS etc. and wants to do the same, look up rs7412 - the C/C combination is "normal", while one T increases your AD risk by 3x and two Ts by 10x.

As it turns out, I do have one T, so I have another really good reason to avoid alcohol entirely - and also to take krill oil, quercetin, resveratrol/pterostilbene, D3, K2, the Bs, and lithium (the recommendations from the study you linked).

Re: Low and moderate alcohol consumption not associated with increased mortality

#106

Earlier quoted context omitted.

I'm in this comment and I don't like it.

In this comment? Or you are in a state of high aclohol consumption?

Not at the time. But frequently.

Re: Low and moderate alcohol consumption not associated with increased mortality

#107

Earlier quoted context omitted.

In this comment? Or you are in a state of high aclohol consumption?

Not at the time. But frequently.

Consider treatment. There are at least 6 treatment options.

I heard good comments about Nalmefene or Naltrexone "as needed" (aka Sinclair Method). Even here on HN if you search for it in comments. Basically, you take a pill an hour before drinking. They suppose it works by blocking formation of conditioned reflex caused by endorphin reinforcement. In absence of reinforcement patient unlearns the habit.

Psychotherapy. In particular, cognitive behavioral therapy (CBT). I think one can provably even study this method himself and apply it.

Group therapy. May be useful IMHO, because people with the same problem can share experience.

Medications to help maintaining abstinence: acamprosate, disulfiram, nalmefene / naltrexone (taken constantly, unlike the Sinclair Method, where they are only taken when drinking).

Disclaimer: I am not a doctor. Just curious about this topic.

A useful link: https://alcoholtreatment.niaaa.nih.gov/

Re: Low and moderate alcohol consumption not associated with increased mortality

#108

Earlier quoted context omitted.

FWIW this policy change has been widely criticized by Canadians for being based on a flawed analysis https://nationalpost.com/opinion/harry-rakowski-how-much-alc...

Haha - good old national post. They also said smoking is good for surviving Covid. I will seek my health info elsewhere. https://nationalpost.com/opinion/colby-cosh-where-theres-smo...

I’d love to hear your detailed critique of that article
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