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A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

nature.com

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Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#101

Post by 0x737368 »

drowsspa wrote: post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

Has nothing to do with fat people not understanding thermodynamics and has everything to do with not being able to follow the simple principle and looking for shortcuts instead.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#102

Post by jjtheblunt »

drowsspa wrote: post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

NEAT?

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#103

Post by ljf »

bollu wrote: post #63
adrian_b wrote: post #37

Earlier quoted context omitted.

For increased satiety, even when eating little, an additional factor is that the food should not be too soft, like most of the industrially made food is, but it should need some time of vigorous chewing. There are many vegetables, fruits and nuts that require a decent amount of chewing. There are also some kinds of home-made bread that require much more chewing than the industrial soft bread, while also being much ta…

Got any chewey bread recipes?

My homemade sour dough is always chewy and tough, but I love it!

[ ] Thursday

[ ] 8am - if starter hasn't been used for 4 weeks or more; feed starter 30g flour and 30g of water

[ ] Thursday evening weigh out flour and salt as below into two bowls, and cover. Get water jug, yeast and teaspoon ready. Keep starter in the fridge until needed

[ ] Friday:

[ ] 1. (8am) Mix 100g of Starter, 200g white flour, 50g wholemeal flour, 200g warm water. Mix and cover. This is the Levain, set aside somewhere room temperature - if you house is very cold you can use extra starter.

[ ] 2. (1pm) Five hours later, in a big bowl mix 100 of white flour, 300g of wholemeal flour, 10g of salt and 330g warm water. Stand for 20 minutes, uncovered.

[ ] 3. (1.20pm) Add a quarter tea spoon of instant yeast and 300g of the levain made this morning to the big bowl, mix all together (leftover levain add to starter you have in the fridge - save for next time or mix and give half to someone else).

[ ] 4.1 (2.30pm) 1st fold. Over the next 2 hours, fold the dough 3 times with wet hands. Roughly mix and blend the dough, no need to kneed.

[ ] 4.2 (3.30pm) 2nd fold

[ ] 4.3 (4.30pm) 3rd fold

[ ] 5. (6pm, approx 5 hours after step 2.) Shape into a ball and place on greaseproof paper in a large bowl. Put in fridge till tomorrow morning.

[ ] Saturday:

[ ] 6. (8am) Remove from fridge. Preheat oven and a cast-iron pot to 245 deg C

[ ] 7. Score top of loaf and place with greaseproof paper in the heated pot and bake for 20 minutes. Remove lid and cook for 25 mins more. Will sound hollow(ish) when tapped once baked. Crust should be a dark brown.

[ ] 8. Remove from pot, take off greaseproof paper and place on a rack. Cool for 20 minutes.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#104

Post by jjtheblunt »

kaibee wrote: post #50
sigg3 wrote: post #31

Earlier quoted context omitted.

> What I've found is that matters is appetite: some people just get full way faster than others. This is a half truth. If you cut down portion size your stomach will shrink over time. I eat a lot less before feeling full now, and I only changed my life a year ago. It's also important that you eat stuff that makes you feel full, fibers and greens. Changing diet also changed my taste, so I crave more healthy things now…

> It's also important that you eat stuff that makes you feel full, fibers and greens. Changing diet also changed my taste, so I crave more healthy things now, while the food I used to eat honestly don't appeal to me any longer or tastes empty. Having tried this, by basically eating a lot of carrots, its uh, not the same as being full/satiated. Feeling like your stomach is full is just a completely different feeling f…

I wonder if the satiated feeling isn't from volume but from some nutrient showing up in blood or in intestinal detectors for something signaled as in short supply.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#105

Post by User23 »

drowsspa wrote: post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

Gym bro science gets a bad rap here for whatever reason, but I’d bet dollars to donuts that you’re better off following a 1970s bodybuilder diet (scaled appropriately) than whatever the latest garbage the FDA and USDA are pushing. Sure plenty of it is nonsense, like eating 6 meals a day, but it’s mostly harmless nonsense. That’s in stark contrast to the food pyramid recommendation to eat a couple loafs of bread each day which is harmful nonsense that has probably played a role in the type 2 diabetes epidemic.

Also it’s entirely plausible that various small molecules like artificial sweeteners, preservatives, solvents, and whatever else goes in the process chemistry products called processed food is in some way or another bioactive and alters homeostasis, perhaps by disrupting the endocrine system or perhaps through other pathways.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#106

Post by huntertwo »

maxk42 wrote: post #58
huntertwo wrote: post #26

Earlier quoted context omitted.

Hormones, appetite, metabolic diseases are all orthogonal to CICO. These can have an effect on how many calories you burn or how many calories you crave but at the end of the day, CICO is still law.

A calorie measures the heat released by setting the food on fire, which is not how your body metabolizes food. It's a proxy. You should be measuring the ATP yielded by eating food. For example, a molecule of glucose yields 32 ATP when metabolized, yet a molecule of DHA yields 136 molecules of ATP - nearly twice as many as predicted by the "calories" proxy. However, in the absence of oxaloacetic acid (as when the live…

> You should be measuring the ATP yielded by eating food.

The closest practical approximation of this is the calorie measurement we assign to foods. Sure our metabolic processes are not equivalent to a calorimeter - but its easier to measure calories than to account for the specific metabolic process each gram of macronutrient you consume goes through.

So for all practical purposes, and in the context of hormonal effects, energy in vs energy out ie CICO is still law.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#107

Post by rojobuffalo »

Tagbert wrote: post #92
rojobuffalo wrote: post #87

Earlier quoted context omitted.

not to get down in the weeds but carrots aren't that fibrous, but their *available fiber content goes up 2.5x when you cook them, from about 2g per stick to 5g. leafy greens, especially kale, are better for filling up. and you still need protein and fat on top of that.

How does boiling increase the fiber content of carrots? Where does the extra fiber come from?

boiling breaks down cell walls which makes nutrients more available. i'm not an expert but i read about it somewhere.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#108

Post by klyrs »

AnIdiotOnTheNet wrote: post #89
klyrs wrote: post #35

Earlier quoted context omitted.

> CICO is still law. Calories are a measure chemical energy, not mass. Our digestive systems don't get anywhere near e=mc^2 in their efficiency. The conservation law is MIMO; calories are way more complicated. For example, people who extol CICO rarely take into account the fact that poop has a variable amount of chemical energy, which depends on a huge variety of factors including gut flora, hydration and fiber intak…

And yet Mark Haub[0] ate a diet of Twinkies (and other convenience store garbage food) to a caloric deficit and lost 27lbs in 10 weeks while all of his health metrics improved. Trying to be super precise about calories may be complicated, but nobody has to do that to reach a caloric deficit anyway so who cares. Eat less than you need by any reasonable ball park metric and you will lose weight, it's that simple. The h…

Sure, let's agree that CICO is a decent rule of thumb, not a law. That's a fun anecdote, though.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#109

Post by huntertwo »

klyrs wrote: post #35
huntertwo wrote: post #26

Earlier quoted context omitted.

Hormones, appetite, metabolic diseases are all orthogonal to CICO. These can have an effect on how many calories you burn or how many calories you crave but at the end of the day, CICO is still law.

> CICO is still law. Calories are a measure chemical energy, not mass. Our digestive systems don't get anywhere near e=mc^2 in their efficiency. The conservation law is MIMO; calories are way more complicated. For example, people who extol CICO rarely take into account the fact that poop has a variable amount of chemical energy, which depends on a huge variety of factors including gut flora, hydration and fiber intak…

https://en.m.wikipedia.org/wiki/Laws_of_thermodynamics

> The laws of thermodynamics define a group of physical quantities, such as temperature, energy, and entropy, that characterize thermodynamic systems in thermodynamic equilibrium.

If you eat 2000 calories of food and burn 2000 calories (taking into account inefficiencies in the metabolic processes our bodies undertake to convert molecules to other molecules), there is no source of energy for you to accumulate fat, regardless of anything else.

Your metabolic rate and the chemical energy of your excrement and the amount of co2 you exhale can be affected by a myriad of factors, hormonal included. But they just change the CO part of the equation, not the fact that CICO is law.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#110

Post by BeetleB »

guerrilla wrote: post #98
BeetleB wrote: post #91

Earlier quoted context omitted.

About a decade ago I read an interview with an applied mathematician about how he applied his knowledge of math to practical applications. I don't recall if he was working for the NSF or the NIH at the time, but his work for the past few years had to do with this. He said that of all the contributing factors to being overweight, the factor that was clearly the most significant by a margin was food production per capi…

> but the problem definitely is eating too much Not necessarily. Eating too much may be the result of whatever the actual problem may be. People know they're eating too much already. They still, very reliably, can't do anything about it.

> People know they're eating too much already. They still, very reliably, can't do anything about it.

Consistent with my comment. That they can't cut down eating doesn't mean the problem isn't overproduction.

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