Earlier quoted context omitted.
We've got to be careful or we're going to end up with super-intelligent immortal mice!
Put flowers on their grave [1] https://en.wikipedia.org/wiki/Flowers_for_Algernon
Don’t forget Mrs. Frisby
In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)
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Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)
#102Did they continue tracking health effects years after they study ? It’s possible the drugs reversed the body clock but will accelerate it after. Much like coffee gives you a temporary boost, then makes you crash later
By what basis do you make this estimation? The factors for aging and feeling awake arent exactly comparable.
They're both cyclical.
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)
#103Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.
One thing I rarely see mentioned in regards to living forever is that during a life you will accumulate mental scars. My wife has lost a sister, and she's witnessed a murder. Neither she nor I are the same after those experiences. I don't think we will ever be. If we lived forever I think we would all become more and more anxious and excentric as time progressed and our souls inevitably became more "scarred". Maybe i…
Isn’t this Cartesian Dualism? The brain is part of the body and it might be possible to reverse damage to it.
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)
#104I thought for a second that this was a branch off of R.
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)
#105I’m no fan of death, but death (by natural causes - age, sickness , accident) has been how different generations have gotten rid some of the worst despots.
Sounds like a self solving problem. I reckon people will start caring about their despots if they expect to live a millennium under the despots' boot
I suspect people not caring is not the main underlying cause of despots.
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)
#106Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.
Increasing functional span is compelling.
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)
#107Earlier quoted context omitted.
One thing I rarely see mentioned in regards to living forever is that during a life you will accumulate mental scars. My wife has lost a sister, and she's witnessed a murder. Neither she nor I are the same after those experiences. I don't think we will ever be. If we lived forever I think we would all become more and more anxious and excentric as time progressed and our souls inevitably became more "scarred". Maybe i…
> eccentric This is good. I always say rich people can't be weird, only eccentric. And chances are if you live for a long time, you have more money :)
Or the difference between genius and insanity is the amount in your account.
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)
#108Earlier quoted context omitted.
This is a good question: > Horvath used four different epigenetic clocks to assess each patient’s biological age, and he found significant reversal for each trial participant in all of the tests. Presumably the "epigenetic clocks" are correlated with age, but it's not clear if changes to the epigenetic clocks causes aging, or aging causes changes to the epigenetic clocks. (Maybe it's both?) Is this like overhauling t…
Exactly. And this is why the FDA won't approve drugs based on changes to biomarker (which is what these "epigenetic clocks" are) unless a direct link between that biomarker and a beneficial outcomes has been proven.
And human lifespan, the best meaningful outcome, is too long for any study to use.
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)
#109Presumably 6 months later you'll have to put your body clock forwards again in time for Spring.
Depends where you live.
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)
#110Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.
I do not believe it is always a nightmare. If one plans for a long health/life span and is always adding forms of diversified income then it is just a matter of hobbies.
One of my personal goals is to tell the great grandchildren of people my age what their great grandparents were like since most of them won't write down the interesting bits of their lives and instagram/snapchat/facebook leaves a distorted image and may not even exist in the future.