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The Uselessness of Phenylephrine

science.org

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Re: The Uselessness of Phenylephrine

#101

Post by joezydeco »

sva_ wrote: post #91
joezydeco wrote: post #76

Earlier quoted context omitted.

Original NyQuil also had a healthy shot of ethyl alcohol in it. Exactly the thing you weren't supposed to mix with pseudoephedrine.

I believe you're just not supposed to drink alcohol on Pseudoephedrine because you'd be combining an upper with a downer, and it's very easy to go overboard with the downers when you're on an upper (tolerance to alcohol increases dramatically and increases overdose risk along with all the other side effects and risks.) So a small amount of alcohol won't really have much of an effect, I'd claim.

In my experiences with old NyQuil it was enough to make you drowsier. And getting to sleep was the primary objective of NyQuil.

Back in my college days you could replicate it with one 30mg Sudafed and a shot of Jagermeister. =)

Re: The Uselessness of Phenylephrine

#103

Post by JshWright »

EamonnMR wrote: post #21

Sometimes I wonder if NSAIDs are the same deal, or if there's just a subset of people they don't work well on.

There is a significant amount of evidence supporting the efficacy of NSAIDs. Note that they are more effective for some types of pain than others, due to the mechanism by which they work.

Re: The Uselessness of Phenylephrine

#104

Post by mh- »

bee_rider wrote: post #97
jjoonathan wrote: post #14

Phenylepherine has excellent "not being easily convertible into meth" properties, if only it had actual decongestant properties to go along with them... Sigh.

I bet sugar pills would be even harder to turn into meth.

And more useful, too. They can be turned into things like Pez, or Tic Tacs.

Re: The Uselessness of Phenylephrine

#105

Post by dylan604 »

f7ebc20c97 wrote: post #90
dylan604 wrote: post #77

Earlier quoted context omitted.

Would that not still require an in-person visit that they've already stated was not possible? I'd assume the state would require a new photo for a new ID at the least to make an in-person visit required. Probably need new fingerpritns as well (if that's something WA does).

Society wouldn't function if people weren't willing to bend the rules.

Not really sure what you're on about here. There's a time and place where bending the rules is possible. Attempting to get a government issued ID and not following the basic rules of showing up in person is not really one of them in my book.

Re: The Uselessness of Phenylephrine

#106

Post by somebodynew »

ncmncm wrote: post #50
The_rationalist wrote: post #6

Levo-methamphetamine is a legal decongestant BTW

Where does one obtain that? From the waste stream of the methamphetamine producers?

It is sold over the counter in most US pharmacies under the Vicks inhaler brand. The active ingredient label conveniently uses a spelling that most people will not recognize which is probably effective in preventing alarm from customers who aren't familiar with the dramatic difference in the effects of the two enantiomers.

Re: The Uselessness of Phenylephrine

#107

Post by Damogran6 »

munificent wrote: post #43

My drug of choice for colds is NyQuil. It's always been great for opening up my nasal passages enough to let me breathe easily and then knocking me the fuck out so I could sleep off most of the cold. I remember several years ago when all of a sudden NyQuil stopped doing anything useful. I had no idea why but I directly observed that it was like it had been replaced with a non-functioning placebo. Only a couple years…

Didn’t they also drop the alcohol percentage? It’s 10% now (I know this because post Covid I seem to be catching EVERYTHING), I could have sworn it was 14% or higher growing up.

Re: The Uselessness of Phenylephrine

#108

Post by oh_sigh »

samatman wrote: post #10
AaronM wrote: post #8

If you get the chance, go read all of his (Derek Lowe) blog posts about things he refuses to work with. Highly entertaining read.

Thanks for pointing out the author, the headline is not news to me and I would have passed on reading it.

Strange that you were reading all the comments about the article you weren't interested in...

Re: The Uselessness of Phenylephrine

#109

Post by cardiffspaceman »

hammock wrote: post #23
patwolf wrote: post #19

I'm also irked by the fact that OTC cough suppressants like dextromethorphan are equally useless.

Citation? Dextromethorphan works very well for me. (Also DXM is a recreational drug which is why it's always sold OTC with either Tylenol in it or as an extended-release formula)

Chris Rock has a few brilliant, hyperbolic, minutes on how in some neighborhoods "tussin" is a cure-all.

Re: The Uselessness of Phenylephrine

#110

Post by vkou »

reincarnate0x14 wrote: post #48
Zak wrote: post #37

Earlier quoted context omitted.

Every time she's mentioned, there's something to make me dislike Feinstein more than I already did. It does seem likely her strong opposition would be a high bar to clear, though as the oldest current senator, she may not be a factor for a long time.

It really is amazing how someone manages to be on the wrong side of seemingly everything, and yet is locked into office past the point of senility.

This means that either your calibration mechanism for 'wrong side' is flawed, or the system is rigged in a way that it consistently produces bad outcomes.

Speaking for myself, am shocked and outraged that red senators and other congresscritters are consistently on the wrong side of seemingly everything, yet they keep getting elected. Of course, my political calibration mechanisms are quite in tune.

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