Surprisingly high number of happily married stoners in here.
> Surprisingly high
;)
Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
101–110 of 139 posts
Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
#102Earlier quoted context omitted.
Fauci himself did claim the vaccinated are "dead ends" to the virus[1]. He dangled the carrot of "herd immunity through vaccination" around but then moved the threshold further and further, even admitting to being dishonest in the process[2]. Of course, we now all know herd immunity with vaccines is impossible and that they do next to nothing to inhibit spread. Perhaps some experts accurately predicted this, but that…
We should make fun of them, instead look at Pzifer, Moderna and the publications around them and other specific vaccines. They are very consistent about their proposed efficacy before they came out, their actual efficacy as they were rolled out, and now their actual decreasing efficacy over time including in the face of other seasonal variants, since we don't have seasonal vaccines.
Well that's great, but the same authorities that just lied to me are also responsible to ensure safety of these vaccines. They're the same ones who tell me it's "safe and effective". Why would anybody trust them now?
Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
#103It's important to note that the chemicals they tested with were the cannabinoid acids (CBDA, THCA). When smoking or cooking those acids are converted via decarboxylation. These final chemicals were not part of this study. In other words, this study only tested people eating raw uncooked cannabis. It does not tell you much about whether any benefits will be provided to your average smoker.
the study did not involve testing on humans, and it even did not involve testing on rats (which imo would not have worked anyway), it is cell assays and binding constants only
Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
#104Totally anecdotal but my girlfriend and I recently went to wedding and even with pre testing and everyone vaccinated, a lot of people got Covid. I was super high that night (as most nights) and walked away unscathed. Obviously this could be due to a lot of things but that hasn’t stopped me from rubbing it in all my friends faces. It’s been of the few times in my life where my weed habit looks smart, and I’m loving ev…
There were some early studies that showed that nicotine had a higher affinity for ACE2 than SARS-CoV-2 and that smokers had a lower risk of catching covid. I told everybody that while ripping my camels.
Worth repeating that this study was retracted. Authors failed to disclose a conflict of interest in their funding from the tobacco industry:
Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
#105I did't know anything about the journal. I must admit, that something titled "Journal of Natural Products" didn't inspire much confidence. But it does look like it has been around for quite a long while, and has a respectable impact factor for a specialized journal too.
Journal of Natural Products is a great journal when it comes to natural products, for example when you elucidate the structure of a complex novel natural product this is a good journal to publish it in (alternatives being eg organic letters). I follow natural products chemistry and together with nat prod rep this is one of the journals where I will make sure to not miss any abstract, this is a top of the line journal in it;s niche.
However in natural products chemistry there is the tendency to inflate the importance of measured biological activity, often you will see it reported this or that new compound is cytotoxic against some random cancer cell line but when you read the fine print the compounds are weak and/or not selective. Often this later can prove as the justification of a total synthesis attempt or as the starting point for optimization into an actually potent drug (which does not succeed that often).
Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
#106Earlier quoted context omitted.
Except they didn't make that point at all, because it's not relevant to a mandate. Please don't try to rewrite the quotes I am citing to make them support your point as that is literally trying to rewrite history. We have a word for that, and it's "gaslighting".
the reason we are talking past each other is because you chose the wrong influencers, sorry thats been your experience. you should be dismayed at public facing communication for the broad audience, since the one time we needed them they messed that up. > on a medical level, it is clear this wasn't to stop the spread, it was to slow the spread as vaccinated infected have smaller viral load for shorter time period comp…
This comment chain represents so many conversations I've seen on HN / Reddit.
The understanding I've come to (flavored by my media diet) is very similar to yours...It is just really hard to have a conversation with each other about events when we can't even agree on the base facts.
It'd be nice if we could figure out how to reduce that gap, especially because a lot of these things are simply facts, not opinions.
And that is not to say I am free from blind spots! I am not saying my media diet is the "right one" that gets to the truth, I know I have them, but I do try and reduce them as best I can.
Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
#107Earlier quoted context omitted.
There were some early studies that showed that nicotine had a higher affinity for ACE2 than SARS-CoV-2 and that smokers had a lower risk of catching covid. I told everybody that while ripping my camels.
Worth repeating that this study was retracted. Authors failed to disclose a conflict of interest in their funding from the tobacco industry: https://erj.ersjournals.com/content/57/3/2002144
In fairness, the study was retracted not due to the data but because "The European Respiratory Society, as a leading medical organisation in the respiratory field whose mission is to promote lung health and alleviate suffering from respiratory disease, has bylaws in place that do not permit individuals with ongoing relationships with the tobacco industry to participate in its activities" and in other situations, "The journal editors acknowledge that COPE (Committee on Publication Ethics) guidelines state that failure to disclose a potential conflict of interest is not normally sufficient grounds for retraction of a published article."
I understand the journal's actions but I'd hesitate to say the study is wrong or has been retracted for anything beyond politics.
Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
#108Earlier quoted context omitted.
There were some early studies that showed that nicotine had a higher affinity for ACE2 than SARS-CoV-2 and that smokers had a lower risk of catching covid. I told everybody that while ripping my camels.
Worth repeating that this study was retracted. Authors failed to disclose a conflict of interest in their funding from the tobacco industry: https://erj.ersjournals.com/content/57/3/2002144
Worth noting that this may or not have any bearing on the conclusions...
"The manuscript presents some new data on, and provides a section of discussion of, the effect of tobacco consumption on patient susceptibility to COVID-19, and cites other studies that claim SARS-CoV-2 infection is less prevalent in smokers or tobacco users." Perhaps reading those other studies would be prejudicial.
I once spend the better part of a day online looking for actual data on the known dangers of second-hand smoke. I found the not-so-surprising answers in a hard-to-find article in Lancet. It ... contradicted the mainstream tale.
Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
#109Earlier quoted context omitted.
We should make fun of them, instead look at Pzifer, Moderna and the publications around them and other specific vaccines. They are very consistent about their proposed efficacy before they came out, their actual efficacy as they were rolled out, and now their actual decreasing efficacy over time including in the face of other seasonal variants, since we don't have seasonal vaccines.
Well that's great, but the same authorities that just lied to me are also responsible to ensure safety of these vaccines. They're the same ones who tell me it's "safe and effective". Why would anybody trust them now?
They have a lot of work to do, I would say look outside of the US and also technologies used by different vaccines worldwide.
A lot of the consternations fall apart, to me, when the aggregate response reaches the same conclusion, something impossible to be done by any guiding hand due to geopolitics.
Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
#110Earlier quoted context omitted.
Since the vaccinations are stopping the spread?
95% of people in New Zealand that are eligible for a vaccine are vaccinated. A population of five million are getting ~30 new cases a day when excluding cases at the border on entry (50 including the border cases). People are causing the spread, not the vaccine.
Why are all of our vaccinated getting omicron, then?
What is the differentiator?