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Reversal of cognitive decline: A novel therapeutic program

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Re: Reversal of cognitive decline: A novel therapeutic program

#101

Maybe I'm a cynic but it strains credulity that the miracle cure is also a laundry list of fad health trends from the the last decade. Gluten free, intermittent fasting, yoga, melatonin, probiotics, etc etc

Just wait for another paper claiming that the ketogenic diet is what really works.

While you wait, how about a book from a neuroscientist? https://www.drperlmutter.com/books/grain-brain-by-david-perl...

Re: Reversal of cognitive decline: A novel therapeutic program

#102

Earlier quoted context omitted.

I think it is pretty easy to deny. The CDC breaks out obesity by demographics[1]. White adults have an obesity rate of ~29%. This is the same as other predominantly white/Anglo countries like Canada, Australia, and the United Kingdom[2]. Maybe 29% is staggeringly unhealthy, but it isn't American culture to be that overweight. Being overweight is fairly widespread and not unique to America. Probably it has more to do…

> it isn't American culture to be that overweight > hispanics and blacks are considerably more overweight than whites Are these people not American?

Those implicit biases can be pretty explicit...

Re: Reversal of cognitive decline: A novel therapeutic program

#103
post #83
post #71

Lots of comments dismissing this out of hand because of lack of evidence, but there aren’t any conventional treatments that are very helpful for Alzheimer’s. The lifestyle adjustments suggested in the protocol are largely healthy, not that hard to do, and offer other health benefits. They are also relatively uncommon so it’s not impossible that a broad based adoption of specific habits along with testing for mycotoxi…

> Lots of comments dismissing this out of hand because of lack of evidence, but there aren’t any conventional treatments that are very helpful for Alzheimer’s. These are harmless until they become harmful. What if we develop a good cure for Alzheimer's in 10 years, this method gets debunked but the method makes many refuse to use the conventional treatment? That isn't a made up scenario, it happens all the time. Anno…

Sure that's possible. But it's also overweighting potential harms in an imaginary future scenario over potential benefits today. One can come up with other imaginary scenarios, not to be too dramatic, but the same arguments were likely made against Semmelweis [0] when he promoted hand washing before delivering babies, or the people who discovered the ketogenic diet helped manage epilepsy in the 1920s. [1]

Scientific progress has often been speculative and messy. The few thousand people with ApoE4 genes who read his book and then actually commit to time-restricted feeding, exercising 4 times a week, sleeping 8 hours, and semi-ketogenic diets might have better outcomes a decade from now than those who don't. If that discourages another few tens of thousands of people from taking a potential blockbuster drug in the early years after its release, fine. It's worth the natural experiment to find out because millions of people are not getting much relief from current treatments [2]. This is even more true given that Alzheimer's isn't communicable.

[0] https://en.wikipedia.org/wiki/Ignaz_Semmelweis

[1] Which is lately experiencing a renaissance see https://charliefoundation.org

[2] Official bodies also continue to approve therapies with evidence that appears inconclusive with a higher degree of certainty than Bredeson's protocol. https://hub.jhu.edu/2021/06/21/fda-aduhelm-approval/

Re: Reversal of cognitive decline: A novel therapeutic program

#104

Earlier quoted context omitted.

I don't see how that sentiment can be read into what I wrote. I looked at three racial groups in America and observed they had different obesity rates. In abstract terms - "You think this quality is specific to the whole. If you divide the whole into three parts you can see the quality differs between the parts. This implies the quality is not specific to the whole." To take that claim and infer that I mean to sugges…

There were 3 different responses that read your post similarly, as though the higher levels of obesity among Hispanic and Black people are unrelated to American culture, as though it doesn't matter what the rates of obesity are among people who aren't White. I suppose the reason why some bristle at your partitioning of American obesity rates into racial groups is that it's unclear that it's particularly relevant. Obe…

There could have been three million such responses. It still wouldn't change the fact that that's a logically incoherent reading of my comment.

The reason to use racial groups in my example, is first because I happened to know obesity differed between the groups, and second because it offers the opportunity to look at similar groups in different countries. This example shows that there is variance within the country and similarity beyond it, which I think makes a good case that the culture of the country is not what's responsible.

Regarding your point on violence, suppose it were the case that left handed people had a murder rate 100x higher than right handed people. Now, imagine too that the OECD countries, or whichever group you would like to compare America too, were 99% right handed and America were only 90% right handed.

Would it make sense in this case to say that American culture was the root of the problem with American violence if right and left handed Americans committed violence at the same right as their OECD counterparts? I wouldn't think so. I would think the explanation would be as simple as "greater proportion of more violent left handers".

I realize in the violence example that I've simplified and exaggerated the case compared to obesity. I am not claiming that obesity rates are similar to my example.

Re: Reversal of cognitive decline: A novel therapeutic program

#105
Jason et al., Looks like no one has any training in neuroscience (or scientific analysis) here, so let's go over the basics: (1) The "debunking" you quote from the Lancet does not address data--it's all opinion. Look at the cases themselves, the changes in cognitive scores, the objective data. In addition to this ancient (2014) paper, which described the first reversals of cognitive decline in patients with AD or pre-AD, we have published 100 documented cases of improvement (in J. Alz Dis and Parkinsonism, publicly available) and posted a successful proof-of-concept trial (https://www.medrxiv.org/content/10.1101/2021.05.10.21256982v...). Note that in the trial, 84% improved their cognitive scores, and even the MRIs improved. We are now doing a larger, randomized, controlled clinical trial. (2) We've published over 220 papers and 3 books; please read these before making silly comments. (3) AD has been completely untreatable, and the best data from pharma simply show a slight slowing of decline, not improvement or even stabilization. We've achieved improvement that has been sustained for years--the first patients started in 2012 and are still improved. So the complaints should take into account the alternatives. (4) How do you think medicine changes? A 100-million-dollar Phase 3 trial as the first step? Please. You need a model, then anecdotal, objective data, then a proof-of-concept trial, then a randomized controlled trial. We are doing all of that, step by step. If you have better results, please publish them; if not, don't impede progress, since there are millions in need. (5) The idea that we are using "fads" is ridiculous--we spent 30 years in the laboratory determining the molecular pathways that drive neurodegeneration, and we then translated those data into a workable clinical approach that has already achieved better clinical outcomes than any other approach. Admittedly it is not simple enough yet, but the disease is dictating the simplicity at this point; we have more work to do to prioritize and scale. (6) Our data and approach are simply systems medicine, and the pushback is coming from the stakeholders in outdated single pharmaceutical medicine--do you really believe that something as complicated as a human brain, beset by a disease as complicated as Alzheimer's, is going to be cured by a single small molecule? Ignoring the various pathways involved? Come on now, The Lancet can afford to act like idiots because they've been around for a while, but most of us need data and outcomes. (7) Our approach is simply to identify the drivers of decline (the current standard of care does not even look for them) and then target those. This type of network analysis is the future of medicine, and frankly it needs a lot more Silicon Valley input and a lot less pharma monotherapy influence. (8) The Alzheimer's field is experiencing many of the same issues as the Opioid Epidemic did--coercion, billions of dollars at stake, pharma-established infrastructure, and needless deaths. The recent FDA decision on aducanumab provides further evidence of this. Please look at the data and compare the various approaches, instead of accepting the opinions of the stakeholders at face value. Thanks.

Re: Reversal of cognitive decline: A novel therapeutic program

#106
post #35

Earlier quoted context omitted.

México, Costa Rica, Korea, and Greece would like a word, on both working harder and eating better: https://www.weforum.org/agenda/2018/01/the-countries-where-p...

Mexico is more overweight than the US and tops your list of reported working hours.

That's very far from the truth: https://en.wikipedia.org/wiki/List_of_countries_by_obesity_r...

In fact, the only other country with a population of more than 200,000 people with a higher obesity rate than the US is Kuwait.

Re: Reversal of cognitive decline: A novel therapeutic program

#107
My conclusion, after reading the book, was that the author knows what test results you need in order to prevent or reverse cognitive decline, but he is no expert in how to get those results. Feel free to ignore whatever he says about how you optimize your test results, but I trust him a lot more on what happens when you have successfully optimized those results.

Re: Reversal of cognitive decline: A novel therapeutic program

#108

tldr personalized techniques: - Optimize diet: minimize simple CHO, minimize inflammation. - Patients given choice of several low glycemic, low inflammatory, low grain diets. - Enhance autophagy, ketogenesis - Fast 12 hr each night, including 3 hr prior to bedtime. - Reduce stress - Personalized—yoga or meditation or music, etc. - Optimize sleep - 8 hr sleep per night; melatonin 0.5mg po qhs; Trp 500mg po 3x/wk if aw…

Can we get one supplement pill that merges all of those that need to be consumed? Kthx.

Eat a can of beans and an entire bunch of bitter greens every day. That covers most of your vitamins and minerals.

Some exceptions apply: Sprinkle flax seeds on top for omega 3s, use iodized salt for iodine (seaweed is high in iodine but also high in bad heavy metals), get fresh air and sunshine for vitamin D, pick out your favorite source of vitamin b12. I believe you'll still need potassium.

For exercise: A good place to start is to walk and bike for transportation. Read this book if you're wanting to be convinced that exercise is a magic pill: Spark: The Revolutionary New Science of Exercise and the Brain

Re: Reversal of cognitive decline: A novel therapeutic program

#109
post #108

Earlier quoted context omitted.

Can we get one supplement pill that merges all of those that need to be consumed? Kthx.

Eat a can of beans and an entire bunch of bitter greens every day. That covers most of your vitamins and minerals. Some exceptions apply: Sprinkle flax seeds on top for omega 3s, use iodized salt for iodine (seaweed is high in iodine but also high in bad heavy metals), get fresh air and sunshine for vitamin D, pick out your favorite source of vitamin b12. I believe you'll still need potassium. For exercise: A good pl…

Oh and sauerkraut or something for the microbiome.
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