The most effective malaria vaccine yet discovered

Post by interestica » Fri, Apr 23, 2021, 9:09 PM UTC

perardi wrote: post #98

The crux of the vaccine technology: This new vaccine (R21) uses a circumsporozoite protein (CSP) antigen – that’s a highly conserved protein of the parasite, involved in several functions as the parasite makes the move from mosquito to human and into different human tissues such as the salivary glands. This has been a vaccine ingredient before, such as in the RTS,S vaccine (the first one ever licensed), but R21 has a…

Post by nanijoe » Fri, Apr 23, 2021, 9:15 PM UTC

ChrisMarshallNY wrote: post #56

Exmoor wrote: post #11

Earlier quoted context omitted.

> Malaria deaths peaked around 930,000 a year in 2004, and is around 600,000 a year now Your link does a good job showing this, but for those who don't click and scroll down it's probably worth mentioning that the vast majority of those deaths are in central Africa. So it's not just a lot of deaths, but it's a really significant portion of the population and, as you said, mostly children.

I grew up in Africa. We weren't as scared of Ebola, as we were, of good old Malaria. It's also the gift that keeps on giving. Once you get it, it does a reunion tour, every now and then, for the rest of your life. At the dinner table, we (expats) used to have a bowl of quinine tablets, set out like a condiment. I really hope this works out, because, thanks to climate change, the lower 48 may get a chance to find some…

Post by ChrisMarshallNY » Fri, Apr 23, 2021, 9:18 PM UTC

nanijoe wrote: post #103

ChrisMarshallNY wrote: post #56

Earlier quoted context omitted.

I grew up in Africa. We weren't as scared of Ebola, as we were, of good old Malaria. It's also the gift that keeps on giving. Once you get it, it does a reunion tour, every now and then, for the rest of your life. At the dinner table, we (expats) used to have a bowl of quinine tablets, set out like a condiment. I really hope this works out, because, thanks to climate change, the lower 48 may get a chance to find some…

I dont know what part of Africa you grew up in, but growing up in Nigeria, no one was scared of Malaria. It is treated pretty much the same way Americans treat getting the Flu

Post by cmckn » Fri, Apr 23, 2021, 9:21 PM UTC

todd8 wrote: post #82

eloff wrote: post #5

What blows me away is in a study group of 734 infants, which benefited from maternal antibodies against malaria, 717 were infected by malaria in the first year of their life. That's nearly 100%, in the first year since birth. That's devastating. The vaccine is showing 77% efficacy in trials in Burkina Faso. That's an ongoing pandemic that makes covid-19 look like a case of the sniffles. Malaria deaths peaked around 9…

Although some posts suggest that the USA may experience malaria at some point in the future because of global warming; in actuality, the USA has already experienced malaria. In 1882, the range of malaria in the USA extended from the Canadian border on the north to southern border with Mexico on the south. The only states of the current 48 contiguous states unaffected were Nevada, Utah, Arizona, Idaho, Main, Vermont,…

Post by jjk166 » Fri, Apr 23, 2021, 9:29 PM UTC

abeppu wrote: post #93

bullfightonmars wrote: post #85

Earlier quoted context omitted.

There is a key sentence of this article that speaks to this: > This new vaccine (R21) uses a circumsporozoite protein (CSP) antigen – that’s a highly conserved protein of the parasite, involved in several functions as the parasite makes the move from mosquito to human and into different human tissues such as the salivary glands. Circumsporozoite protein is a highly conserved protein meaning that it is a genetic seque…

I see. So the 23% does not suggest that, e.g. there's some minority of parasites that are "immune" already.