101–110 of 116 posts
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You are reading way, way too much into what I actually said. This is obviously a political issue for you and I have no desire to engage any further. Good day, sir.
Apologies if I did. There are a large number of people who believe that the reason we don't use HCQ is due to a conspiracy. You may have just wanted to point out that the combination has never been used.
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Is there something specific that's wrong with their math?
They're lacking sufficient data to draw any real conclusions. Trend spotting like this requires very large data sets. It would be more interesting to look at (say) NHS data. That's the quick way to avoid this sort of guessing...
It doesn't prevent the hospitalization, it prevents the symptoms that lead to hospitalization.
From a lay perspective, That seems a bit pedantic
It's just sloppily written title that ends up asserting something that is baseless, misleading, and untrue.
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“ Keep in mind that Hydroxychloroquine is one of the existing drugs discovered to have some effect on early infections, but it clearly failed to have much impact on late-stage infections” Do you mind sharing your evidence that HCQ helps with early infections? Because I know many studies that showed no benefit, for example: https://www.nejm.org/doi/full/10.1056/nejmoa2016638 That is one of many studies.
The proposed mechanism for HCQ (zinc affinity) implies that it would be most effective if taken before the onset of symptoms, perhaps even before viral load is high enough to test positive. Obviously this makes it challenging to do a study. Nearly all studies that I’m aware of are initiated on patients that are already showing symptoms, because the patients are enrolled at the hospital, and few have the necessary zin…
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The proposed mechanism for HCQ (zinc affinity) implies that it would be most effective if taken before the onset of symptoms, perhaps even before viral load is high enough to test positive. Obviously this makes it challenging to do a study. Nearly all studies that I’m aware of are initiated on patients that are already showing symptoms, because the patients are enrolled at the hospital, and few have the necessary zin…
(pre-covid) I had an older co-worker that told me he doesn't regularly supplement w. vitamins, but as soon as he feels himself coming down with something, he takes some zinc, and said he could usually kick most colds before they really got a hold. I'd never heard of that before, and would always try vitamin C or whatever. I've tried zinc once, (again, pre covid days), and I guess I kicked whatever I was about to get.…
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What sucks most is that there are several medicines that have found to have a positive effect that got drowned in the HCQ noise.
There are a lot of potential medications that are being studied and it's good to remember that we have to do good science to know what we are doing. So far, only steroids (specifically dexamethasone) has shown a mortality reduction. Remdesivir maybe decreases length of stay in the hospital. Currently beside fluvoxamine, there is research being done on colchicine (usually used for gout), ivermectin (controversial beca…
The study claims they do reduce mortality. It is, however, a non-reviewed preprint.
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Vitamin D is still being discussed quite a lot on HN. My understanding is that it boils down to "It helps those who are deficient but doesn't do much, if anything, if you aren't deficient." Now, a lot of people are deficient -- probably more now than usual due to the lock down because people aren't getting out much, so people are getting less sun exposure. So I tend to get downvoted when I say things like "If you are…
One possible candidate drug I’ve read quite a bit about but have not seen anything on HN about is high-dose melatonin, and even typical melatonin use is associated with a lower chance of testing positive. There’s a bunch of papers discussing how it _could_ be useful, there are several studies underway but none have been completed yet.
But zinc is another thing that looks promising from what I gather.
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There's a bunch of very professional-looking websites claiming the effectiveness of HCQ, especially early on : https://hcqtrial.com/ https://hcqmeta.com/ (And now https://c19study.com/ ?) Sadly, I only have been able to find this as criticism : https://sciencebasedmedicine.org/hcqtrial-com-astroturf-and-...
EDIT: Also note that those links are all the run by the same group, the FAQs are the same. Consider reading the IDSA (Infectious Disease Society of America) guidelines. They get updated fairly regularly and are composed of the boots on the ground infectious disease specialist physicians who are trying to help people. https://www.idsociety.org/practice-guideline/covid-19-guidel... Unfortunately, HCQ became politicized…
There's also this point of view :
https://freerepublic.com/focus/f-news/3858145/posts
A later, more polished and detailed version in French :
https://www.agoravox.fr/tribune-libre/article/traitements-a-...
However, while I had found these arguments compelling, the issue was that they took the effectiveness of HCQ as a starting point. Which just seems to go against the available evidence at this point.
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Vitamin D has been shown to reduce severity in several different studies. Everyone should consider taking it. https://www.reddit.com/r/COVID19/search?q=vitamin+D&restrict... https://www.youtube.com/watch?v=vN30emwcNS4
Its also been shown not to have an effect in at least one RCT, but the problem is social media skews against spreading that information (its kind of a downer so it won't get shared so much) https://www.medrxiv.org/content/10.1101/2020.11.16.20232397v... (Yes, the RCT uses cholecalciferol instead of calcifediol, so the reason why the intervention did not work may be that its a bit late. Yes, the Spanish trial had extr…