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An LSD Trip “Off-Switch” May Be Coming Soon

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Re: An LSD Trip “Off-Switch” May Be Coming Soon

#101

Earlier quoted context omitted.

protip.. Try and force yourself to eat, it gives you one less thing for your body to be weird about.

Your body can definitely handle fasting for half a day. Frankly eating gives your body more things to be weird about.

This is one of those scenarios where the Huel/Soylent style mixtures come in handy. It can be difficult to "eat" but sometimes you just need Calories™

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#102

So no info on what it actually is. Just some company filing a patent. And the fact that they call it "a neutralizer technology" suggests that it's probably just a bunch of BS combined with previously known drugs to make it patentable. I'm pretty sure there's at least some published research on using at least one antipsychotic for that and mountains of "folk research" on using benzodiazepines.

I'm curious what would be the market for this? wouldn't that be an extremely niche scenario within the emergency-response medicine where people inexperienced with LSD who suffer a bad trip ask to be taken off it? afaik LSD isn't a drug that one is likely to OD from either.

There's a lot of inconveniences with drugs that have very long half-lives and very low effective doses. Alcohol lasts for an hour or two; with LSD, you're out for 24. You can't just take less, or it won't work. So this would allow for shorter trips.

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#103

Earlier quoted context omitted.

I'm curious what would be the market for this? wouldn't that be an extremely niche scenario within the emergency-response medicine where people inexperienced with LSD who suffer a bad trip ask to be taken off it? afaik LSD isn't a drug that one is likely to OD from either.

Psilocybin (from mushrooms) and MDMA are both fast tracked for FDA approval as adjuncts to therapy. Psychedelics are poised to become the most common psychiatric treatment in the world, with ongoing trials showing huge effects for treating PTSD, addiction, and treatment-resistant depression. Despite a lot of therapeutic promise, LSD has not received as much research attention, primarily because of its duration of eff…

Results from studies that used an antipsychotic across the board would not be generalizeable to traditional experiences. At that point, why use L in the first place if older, faster acting substances are available. Mescaline and psilocybine have been used in spiritual and therapeutic settings for hundreds, if not thousands, of years. Where is the interest in L coming from, if not ease of slipping it past customs and other law enforcement?

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#104

So no info on what it actually is. Just some company filing a patent. And the fact that they call it "a neutralizer technology" suggests that it's probably just a bunch of BS combined with previously known drugs to make it patentable. I'm pretty sure there's at least some published research on using at least one antipsychotic for that and mountains of "folk research" on using benzodiazepines.

I'm curious what would be the market for this? wouldn't that be an extremely niche scenario within the emergency-response medicine where people inexperienced with LSD who suffer a bad trip ask to be taken off it? afaik LSD isn't a drug that one is likely to OD from either.

It might make a little sense for Emergency Rooms to have in response to the "bad trips" that result in people calling an ambulance.

But I think the primary reason they would want to develop this would be to encourage LSD to be used as a therapy drug. A lot of people would be more comfortable experimenting in a controlled/legal setting if they new they had an off switch in case anything went wrong.

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#105

Earlier quoted context omitted.

How about alcohol? I’ve only had one third of a trip and towards the end whiskey took some of the edge off.

I've never been able to even contemplate eating while tripping and the idea of drinking alcohol while tripping turns my stomach, I find it much easier to just take some alprazolam or diazepam if things start getting out of hand. That's just me personally though, I've tripped with a guy who went and bought and ate a whole chicken while tripping...

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Re: An LSD Trip “Off-Switch” May Be Coming Soon

#107
Wow. So basically they re-invented Xanax? :P

Joking aside, No way there is any chance that you would stick this in a human (huge potential for harm, no real clinical use case).

LSD is an insanely potent 5HT agonist, it seems highly unlikely any drug that is not "serious" would cause any significant reduction in LSD effects. Benzo's like Xanax can make the trip go in a direction that is less negative... but you are still tripping balls.

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#108
post #54

Earlier quoted context omitted.

Or a bit of MDMA

MDMA will not reduce the effects of LSD but remove the element of fear and bring your imagination into more pleasant areas. This is something that Rick Doblin, the founder of MAPS, describes in the latest Tim Ferriss podcast.

Just wanted to say thanks for bringing attention to this interview . I really enjoy Rick's thoughts on these issues
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