Your link is a video of anti-sugar crusader Robert Lustig's talk at UCSF. It was posted on July 30, 2009, right around the time that the revelations about the contamination of HFCS with mercury started to become known. Mercury exposure is associated with diabetes and metabolic syndrome [2].

While I think Lustig is genuine, he was not aware in 2009 that Fructose is also manufactured/metabolized by the brain [0] [1].

I think the stealth calories in HFCS (as starch), above and beyond the label, is an additional as-yet unappreciated factor in presentations of insulin resistance and obesity.

The HFCS problem is multi-faceted.

[0] The human brain makes fructose, researchers discover – here’s why that might be a big deal (2017) - https://theconversation.com/the-human-brain-makes-fructose-r...

[1] Specific regions of the brain are capable of fructose metabolism (2017) - https://www.ncbi.nlm.nih.gov/pubmed/28034722 - "Furthermore, rates of fructose oxidation in these brain regions are 15-150 times that of liver slices, confirming the bioinformatics prediction and in situ hybridization data. This suggests that previously unappreciated regions across the brain can use fructose, in addition to glucose, for energy production."

[2] Is mercury exposure causing diabetes, metabolic syndrome and insulin resistance? A systematic review of the literature (2017) - https://www.ncbi.nlm.nih.gov/pubmed/28482296